GM-CSF: A Promising Target in Inflammation and Autoimmunity.
GM-CSF
autoimmunity
inflammation
therapeutic
Journal
ImmunoTargets and therapy
ISSN: 2253-1556
Titre abrégé: Immunotargets Ther
Pays: New Zealand
ID NLM: 101606565
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
09
2020
accepted:
15
10
2020
entrez:
5
11
2020
pubmed:
6
11
2020
medline:
6
11
2020
Statut:
epublish
Résumé
The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly identified as being able to induce in vitro the proliferation and differentiation of bone marrow progenitors into granulocytes and macrophages. Much preclinical data have indicated that GM-CSF has a wide range of functions across different tissues in its action on myeloid cells, and GM-CSF deletion/depletion approaches indicate its potential as an important therapeutic target in several inflammatory and autoimmune disorders, for example, rheumatoid arthritis. In this review, we discuss briefly the biology of GM-CSF, raise some current issues and questions pertaining to this biology, summarize the results from preclinical models of a range of inflammatory and autoimmune disorders and list the latest clinical trials evaluating GM-CSF blockade in such disorders.
Identifiants
pubmed: 33150139
doi: 10.2147/ITT.S262566
pii: 262566
pmc: PMC7605919
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
225-240Informations de copyright
© 2020 Lee et al.
Déclaration de conflit d'intérêts
The employer of K.M.-C. L., A.A.A and J.A.H., the University of Melbourne, has licensed patented technology relating to therapeutically targeting GM-CSF to MorphoSys AG, Germany.
Références
Eur Cytokine Netw. 1994 Jan-Feb;5(1):43-6
pubmed: 8049356
Am J Respir Crit Care Med. 2009 Sep 15;180(6):521-32
pubmed: 19590023
Int Arch Allergy Immunol. 1998 Dec;117(4):248-54
pubmed: 9876226
J Mol Med (Berl). 2011 Apr;89(4):321-9
pubmed: 21079906
J Neuroinflammation. 2013 Mar 04;10:35
pubmed: 23452918
World J Gastroenterol. 2018 Feb 7;24(5):623-630
pubmed: 29434451
J Immunol. 2000 Jul 1;165(1):49-58
pubmed: 10861034
Ann Rheum Dis. 2017 Jun;76(6):1020-1030
pubmed: 28213566
Am J Respir Crit Care Med. 2011 Jul 15;184(2):259-68
pubmed: 21474645
Nature. 2006 Dec 14;444(7121):860-7
pubmed: 17167474
Immunity. 2015 Jun 16;42(6):1197-211
pubmed: 26084029
Trends Immunol. 2018 Mar;39(3):240-255
pubmed: 29338939
J Endotoxin Res. 2006;12(1):10-20
pubmed: 16420740
Ann Clin Transl Neurol. 2017 Apr 17;4(5):351-355
pubmed: 28491903
J Immunol. 1998 Oct 1;161(7):3639-44
pubmed: 9759887
Immunity. 2018 Jun 19;48(6):1220-1232.e5
pubmed: 29802020
J Exp Med. 2014 Jun 2;211(6):1243-56
pubmed: 24821911
J Neurosci. 2019 Jun 26;39(26):5222-5233
pubmed: 31015342
Front Mol Neurosci. 2014 Nov 11;7:87
pubmed: 25426020
Cell Res. 2008 Dec;18(12):1220-9
pubmed: 19030026
J Neuroinflammation. 2015 Jun 30;12:128
pubmed: 26123499
Thromb Haemost. 2016 Aug 1;116(2):317-27
pubmed: 27173404
Gastroenterology. 2012 Feb;142(2):335-45
pubmed: 22057112
J Immunol. 1995 Jun 1;154(11):5842-50
pubmed: 7538533
Front Immunol. 2019 Sep 04;10:2055
pubmed: 31552022
J Immunol. 2020 Aug 1;205(3):822-829
pubmed: 32611724
Cell Death Dis. 2018 Feb 15;9(3):267
pubmed: 29449600
Arthritis Res Ther. 2019 Aug 2;21(1):183
pubmed: 31375130
Immunity. 2015 Jul 21;43(1):187-99
pubmed: 26200014
Immunity. 2012 Dec 14;37(6):1116-29
pubmed: 23200826
Eur Neurol. 1993;33(2):152-5
pubmed: 8467823
Arthritis Rheumatol. 2018 Jan;70(1):49-59
pubmed: 28941039
Immunity. 2012 Jun 29;36(6):1031-46
pubmed: 22749353
J Immunol. 2016 Feb 15;196(4):1810-21
pubmed: 26755822
J Pathol. 2020 Jan;250(1):55-66
pubmed: 31579932
Rheumatology (Oxford). 2014 Oct;53(10):1901-5
pubmed: 24831058
Nat Rev Gastroenterol Hepatol. 2015 Apr;12(4):205-17
pubmed: 25732745
FASEB J. 2017 Jun;31(6):2612-2624
pubmed: 28274989
Nat Commun. 2017 Nov 15;8(1):1510
pubmed: 29142230
Arthritis Rheumatol. 2014 Jul;66(7):1755-67
pubmed: 24664521
Nat Immunol. 2011 Mar;12(3):231-8
pubmed: 21240265
J Cereb Blood Flow Metab. 2008 Jan;28(1):29-43
pubmed: 17457367
Nat Med. 2020 Jun;26(6):842-844
pubmed: 32398875
Am J Respir Crit Care Med. 2014 Apr 15;189(8):899-908
pubmed: 24661094
Ann Rheum Dis. 2013 Feb;72(2):265-70
pubmed: 22833372
Nat Rev Dis Primers. 2019 Mar 7;5(1):16
pubmed: 30846703
Science. 2012 Feb 3;335(6068):597-601
pubmed: 22245738
J Clin Invest. 2007 Jan;117(1):175-84
pubmed: 17200717
Elife. 2016 Jan 18;5:e10066
pubmed: 26780670
Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1038-46
pubmed: 18765677
Nat Cell Biol. 2017 Aug;19(8):974-987
pubmed: 28737771
J Immunol. 2020 Jul 1;205(1):213-222
pubmed: 32461237
Scand J Immunol. 2016 Jul;84(1):3-11
pubmed: 27040161
Clin Sci (Lond). 2020 Jul 17;134(13):1735-1749
pubmed: 32608482
J Immunol. 2018 Dec 15;201(12):3677-3682
pubmed: 30413670
Expert Opin Biol Ther. 2012 Dec;12(12):1661-8
pubmed: 23094973
Gut Microbes. 2014 Jul 1;5(4):476-84
pubmed: 25045999
Arthritis Res Ther. 2019 Apr 18;21(1):101
pubmed: 30999929
Eur J Pharmacol. 2007 Feb 28;557(2-3):230-5
pubmed: 17174948
Blood. 1980 Dec;56(6):947-58
pubmed: 7002232
J Exp Med. 2001 Oct 1;194(7):873-82
pubmed: 11581310
JCI Insight. 2018 Mar 22;3(6):
pubmed: 29563337
J Immunol. 2017 Jan 15;198(2):691-698
pubmed: 27974457
JAMA Intern Med. 2020 Sep 1;180(9):1152-1154
pubmed: 32602883
J Immunol. 2008 Oct 1;181(7):5062-70
pubmed: 18802110
J Immunol. 2007 Jan 1;178(1):39-48
pubmed: 17182538
J Exp Med. 1992 Dec 1;176(6):1693-702
pubmed: 1460426
Eur J Immunol. 2015 Jun;45(6):1808-19
pubmed: 25756873
Mol Pain. 2013 Sep 25;9:48
pubmed: 24067145
Science. 2020 May 1;368(6490):473-474
pubmed: 32303591
Arthritis Res Ther. 2012 Sep 20;14(5):R199
pubmed: 22995428
Am J Physiol Lung Cell Mol Physiol. 2018 Jun 1;314(6):L1010-L1025
pubmed: 29469612
J Clin Invest. 1989 Mar;83(3):876-82
pubmed: 2646320
Mediators Inflamm. 2014;2014:241840
pubmed: 25484525
Eur J Immunol. 1992 Jun;22(6):1447-54
pubmed: 1601035
J Neurosci. 2001 Jul 15;21(14):5027-35
pubmed: 11438578
J Clin Invest. 2009 Jan;119(1):61-9
pubmed: 19075395
J Immunol. 2007 Apr 15;178(8):5245-52
pubmed: 17404308
J Clin Invest. 2003 Dec;112(12):1821-30
pubmed: 14679177
Arthritis Res. 2001;3(5):293-8
pubmed: 11549370
Cell Death Differ. 2009 Nov;16(11):1438-44
pubmed: 19609275
Immunopharmacol Immunotoxicol. 1998 Aug;20(3):373-82
pubmed: 9736442
Immunotherapy. 2016 Jul;8(8):959-70
pubmed: 27381687
J Rheumatol. 2016 Apr;43(4):771-8
pubmed: 26980579
J Immunol. 2005 Nov 15;175(10):6570-9
pubmed: 16272311
J Immunol. 2014 Mar 1;192(5):2202-9
pubmed: 24489100
J Exp Med. 2003 Mar 3;197(5):585-99
pubmed: 12615900
Ann Rheum Dis. 2016 May;75(5):899-907
pubmed: 25923217
Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5592-6
pubmed: 8202532
Immunity. 2016 Nov 15;45(5):963-973
pubmed: 27851925
Science. 2014 Mar 28;343(6178):1249288
pubmed: 24625929
Br J Dermatol. 2019 Jun;180(6):1352-1360
pubmed: 30207587
Blood Adv. 2017 Jun 07;1(14):947-960
pubmed: 29296736
Nat Rev Drug Discov. 2016 Dec 29;16(1):53-70
pubmed: 28031576
Nat Commun. 2015 Apr 29;6:6994
pubmed: 25923510
J Exp Med. 2016 Sep 19;213(10):1983-98
pubmed: 27595596
Int Immunol. 2015 Jan;27(1):11-20
pubmed: 25087232
Sci Transl Med. 2015 Oct 21;7(310):310ra166
pubmed: 26491076
Sci Rep. 2018 Jul 31;8(1):11485
pubmed: 30065264
Blood. 2009 Apr 2;113(14):3190-7
pubmed: 19196868
Lancet. 2002 Nov 9;360(9344):1478-80
pubmed: 12433518
J Biol Chem. 2018 Jul 20;293(29):11415-11423
pubmed: 29871928
Nat Med. 2009 Jul;15(7):802-7
pubmed: 19525966
Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1194-E1203
pubmed: 29358392
Blood. 2010 Apr 22;115(16):3346-53
pubmed: 20173116
Immunity. 2001 Oct;15(4):557-67
pubmed: 11672538
J Neural Transm (Vienna). 2012 Nov;119(11):1389-406
pubmed: 22430742
Eur J Immunol. 2018 Sep;48(9):1522-1538
pubmed: 29953616
J Immunol. 2019 May 15;202(10):3033-3040
pubmed: 30988114
Mucosal Immunol. 2017 May;10(3):705-715
pubmed: 27731325
Nat Genet. 2012 Mar 25;44(5):511-6
pubmed: 22446963
Osteoarthritis Cartilage. 2020 Apr;28(4):486-491
pubmed: 32028021
Z Rheumatol. 1992 May-Jun;51(3):121-6
pubmed: 1502858
J Immunol. 2015 Jul 1;195(1):134-44
pubmed: 26019271
J Exp Med. 2008 Sep 29;205(10):2281-94
pubmed: 18779348
Nat Immunol. 2011 Jun;12(6):568-75
pubmed: 21516111
Rheumatology (Oxford). 2020 Nov 1;59(11):3452-3457
pubmed: 32365364
Immunity. 2020 Aug 18;53(2):335-352.e8
pubmed: 32610077
J Biol Chem. 2002 Nov 8;277(45):42808-14
pubmed: 12208854
N Engl J Med. 2009 Dec 31;361(27):2679-81
pubmed: 20042763
J Immunol. 2015 Mar 1;194(5):2424-38
pubmed: 25653427
J Biol Chem. 2015 Jun 5;290(23):14656-67
pubmed: 25931125
Nature. 2003 Nov 27;426(6965):454-60
pubmed: 14647385
Blood. 2012 Apr 12;119(15):3383-93
pubmed: 22323450
Am J Hematol. 2004 Apr;75(4):179-89
pubmed: 15054806
Blood. 2020 Aug 13;136(7):909-913
pubmed: 32294158
Sci Adv. 2019 Aug 14;5(8):eaax3387
pubmed: 31453341
Ann Neurol. 2000 Jun;47(6):707-17
pubmed: 10852536
Immunobiology. 2008;213(9-10):859-70
pubmed: 18926300
J Immunol. 2018 Feb 1;200(3):966-973
pubmed: 29288202
Sci Transl Med. 2014 Jun 18;6(241):241ra80
pubmed: 24944195
Nat Immunol. 2010 Oct;11(10):936-44
pubmed: 20729857
Inflamm Bowel Dis. 2019 Feb 21;25(3):547-560
pubmed: 30124884
J Neuroinflammation. 2014 Dec 02;11:201
pubmed: 25441979
Melanoma Res. 2002 Apr;12(2):123-8
pubmed: 11930108
Arthritis Res Ther. 2017 Mar 9;19(1):53
pubmed: 28274253
Mol Ther Nucleic Acids. 2016 May 03;5:e316
pubmed: 27138176
Immunity. 2014 Jul 17;41(1):14-20
pubmed: 25035950
Blood. 1989 Dec;74(8):2769-70
pubmed: 2510837
Immunity. 2013 Oct 17;39(4):722-32
pubmed: 24076050
Front Immunol. 2020 Jul 16;11:1520
pubmed: 32765525
Int J Clin Pharmacol Ther. 2018 Nov;56(11):507-517
pubmed: 30168415
Science. 2015 May 22;348(6237):aaa6566
pubmed: 25999512
J Clin Invest. 2011 Jul;121(7):2898-910
pubmed: 21633167
Cell Rep. 2020 Jul 7;32(1):107857
pubmed: 32640223
Front Immunol. 2018 Jul 02;9:1544
pubmed: 30013577
Clin Rev Allergy Immunol. 2017 Oct;53(2):265-276
pubmed: 28488248
Nature. 2017 Feb 8;542(7640):177-185
pubmed: 28179656
J Exp Med. 2010 May 10;207(5):953-61
pubmed: 20421390
Blood. 2019 Feb 14;133(7):697-709
pubmed: 30463995
Arthritis Rheumatol. 2018 May;70(5):679-689
pubmed: 29361199
Clin Rev Allergy Immunol. 2010 Feb;38(1):20-31
pubmed: 19437144
J Neurosci. 2020 Mar 11;40(11):2189-2199
pubmed: 32019828
Sci Transl Med. 2018 Nov 28;10(469):
pubmed: 30487251
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16001-6
pubmed: 16243976
J Exp Med. 2020 May 4;217(5):
pubmed: 32097462
Clin Exp Immunol. 2015 Apr;180(1):143-54
pubmed: 25393692
Cell Res. 2014 Dec;24(12):1387-402
pubmed: 25412660
J Clin Invest. 1999 Feb;103(4):563-9
pubmed: 10021465
J Leukoc Biol. 2019 Jun;105(6):1183-1194
pubmed: 30942918
J Clin Invest. 2016 Sep 1;126(9):3453-66
pubmed: 27525438
J Exp Med. 2013 Sep 23;210(10):1977-92
pubmed: 24043763
Expert Rev Clin Immunol. 2018 Jan;14(1):69-82
pubmed: 29202589
J Exp Med. 2020 Jan 6;217(1):
pubmed: 31611249
J Immunol. 2009 Aug 1;183(3):1598-606
pubmed: 19592658
Pain. 2018 Mar;159(3):550-559
pubmed: 29351125
J Exp Med. 2001 Sep 17;194(6):847-53
pubmed: 11560999
Cell. 2008 Aug 8;134(3):496-507
pubmed: 18692472
Ann Rheum Dis. 2005 Sep;64(9):1263-7
pubmed: 15731292
PLoS One. 2013;8(3):e58598
pubmed: 23554905
N Engl J Med. 2003 Dec 25;349(26):2527-39
pubmed: 14695413
J Neuroimmunol. 2020 Aug 15;345:577281
pubmed: 32534388
Allergy. 2009 Jul;64(7):995-1002
pubmed: 19630858
J Neuroimmunol. 2015 Jan 15;278:162-73
pubmed: 25468272
PLoS One. 2012;7(7):e40523
pubmed: 22808181
Nat Rev Rheumatol. 2016 Jan;12(1):37-48
pubmed: 26633290
Arthritis Res Ther. 2018 Apr 5;20(1):62
pubmed: 29622035
Cell Immunol. 2002 Oct;219(2):92-7
pubmed: 12576027
Immunity. 2013 Oct 17;39(4):697-710
pubmed: 24138881
Mediators Inflamm. 2013;2013:245804
pubmed: 24453413
J Immunol. 2004 Nov 15;173(10):6384-92
pubmed: 15528378
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Nat Commun. 2013;4:2990
pubmed: 24356538
J Immunol. 2011 May 1;186(9):5468-77
pubmed: 21421852
J Immunol. 2014 Jul 15;193(2):849-59
pubmed: 24951817
J Exp Med. 2012 Jul 30;209(8):1505-17
pubmed: 22802353
J Heart Lung Transplant. 2020 May;39(5):405-407
pubmed: 32362390
Obesity (Silver Spring). 2016 Oct;24(10):2140-9
pubmed: 27515998
Nat Rev Immunol. 2008 Jul;8(7):533-44
pubmed: 18551128
Ann Rheum Dis. 2015 Jun;74(6):1058-64
pubmed: 24534756
Nat Rev Immunol. 2020 Aug;20(8):507-514
pubmed: 32576980
Nat Immunol. 2011 Jun;12(6):560-7
pubmed: 21516112
Am J Physiol Gastrointest Liver Physiol. 2014 Mar;306(6):G455-65
pubmed: 24503766
Cell Host Microbe. 2020 Jun 10;27(6):992-1000.e3
pubmed: 32320677
J Neuroinflammation. 2012 Dec 13;9:268
pubmed: 23234315
Nature. 2015 Jan 15;517(7534):293-301
pubmed: 25592534
Lancet Rheumatol. 2020 Aug;2(8):e465-e473
pubmed: 32835256
J Leukoc Biol. 2002 Mar;71(3):511-9
pubmed: 11867689
Am J Physiol. 1999 Apr;276(4):L556-63
pubmed: 10198353
Front Immunol. 2020 Jul 03;11:1625
pubmed: 32719685
J Immunol. 2012 Jun 1;188(11):5752-65
pubmed: 22547697
Growth Factors. 2004 Dec;22(4):225-31
pubmed: 15621725
Semin Immunopathol. 2019 May;41(3):283-297
pubmed: 30891627
BMJ Open. 2016 Jan 06;6(1):e007709
pubmed: 26739717
J Exp Med. 2020 Jun 1;217(6):
pubmed: 32302401
J Clin Invest. 2013 May;123(5):2317-31
pubmed: 23585475
Nat Med. 2020 Oct;26(10):1636-1643
pubmed: 32839624
Cell Res. 2016 Jan;26(1):83-102
pubmed: 26691752
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
Blood. 1992 Sep 15;80(6):1565-75
pubmed: 1355672
Inflamm Bowel Dis. 2010 Mar;16(3):428-41
pubmed: 19639560