Primary Tumor Histology Affects Oncological Outcomes Independently of the Anatomical Extent of Disease in Colorectal Liver Metastasis.
colorectal liver metastasis
desmoplastic reaction
epithelial-mesenchymal transition (EMT)
hepatectomy
poorly differentiated cluster
Journal
JMA journal
ISSN: 2433-3298
Titre abrégé: JMA J
Pays: Japan
ID NLM: 101769797
Informations de publication
Date de publication:
15 Jul 2020
15 Jul 2020
Historique:
received:
17
05
2017
accepted:
08
05
2020
entrez:
5
11
2020
pubmed:
6
11
2020
medline:
6
11
2020
Statut:
ppublish
Résumé
Growing evidence indicates the prognostic importance of the crosstalk between cancer cells and stroma through the induction of epithelial-mesenchymal transition (EMT). This study aimed to clarify the prognostic value of evaluating primary tumor histology with the anatomical extent of disease in patients with colorectal liver metastasis (CRLM). Prognostic analyses were performed in 411 CRLM patients who underwent hepatectomy at two institutions. Tumors were graded into one of three histological categories based on integrated assessment of EMT-associated histology (Histology A prognostic grouping system for the anatomical extent of disease (N stage, liver metastasis number and size, and extrahepatic disease; Grade Histological assessment of dedifferentiation and the stromal environment of primary tumors contributed to effective risk stratification of early relapse after hepatectomy, which could be useful to determine clinical management for CRLM patients.
Identifiants
pubmed: 33150258
doi: 10.31662/jmaj.2018-0004
pmc: PMC7590386
doi:
Types de publication
Journal Article
Langues
eng
Pagination
240-250Informations de copyright
Copyright © Japan Medical Association.
Déclaration de conflit d'intérêts
None
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