Validation of Prognostic Radiomic Features From Resectable Pancreatic Ductal Adenocarcinoma in Patients With Advanced Disease Undergoing Chemotherapy.
Adenocarcinoma
/ diagnostic imaging
Aged
Carcinoma, Pancreatic Ductal
/ diagnostic imaging
Cohort Studies
Female
Humans
Male
Middle Aged
Pancreas
/ diagnostic imaging
Pancreatic Neoplasms
/ diagnostic imaging
Prognosis
Reproducibility of Results
Retrospective Studies
Tomography, X-Ray Computed
/ methods
computed tomography
machine learning
pancreatic ductal adenocarcinoma
prognosis
radiomic analysis
Journal
Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
ISSN: 1488-2361
Titre abrégé: Can Assoc Radiol J
Pays: United States
ID NLM: 8812910
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
pubmed:
6
11
2020
medline:
21
10
2021
entrez:
5
11
2020
Statut:
ppublish
Résumé
Radiomic features in pancreatic ductal adenocarcinoma (PDAC) often lack validation in independent test sets or are limited to early or late stage disease. Given the lethal nature of PDAC it is possible that there are similarities in radiomic features of both early and advanced disease reflective of aggressive biology. To assess the performance of prognostic radiomic features previously published in patients with resectable PDAC in a test set of patients with unresectable PDAC undergoing chemotherapy. The pre-treatment CT of 108 patients enrolled in a prospective chemotherapy trial were used as a test cohort for 2 previously published prognostic radiomic features in resectable PDAC (Sum Entropy and Cluster Tendency with square-root filter[Sqrt]). We assessed the performance of these 2 radiomic features for the prediction of overall survival (OS) and time to progression (TTP) using Cox proportional-hazard models. Sqrt Cluster Tendency was significantly associated with outcome with a hazard ratio (HR) of 1.27(for primary pancreatic tumor plus local nodes), (Confidence Interval(CI):1.01 -1.6, The CT radiomic feature Sqrt Cluster Tendency, previously demonstrated to be prognostic in resectable PDAC, remained a significant prognostic factor for OS and TTP in a test set of unresectable PDAC patients. This radiomic feature warrants further investigation to understand its biologic correlates and CT applicability in PDAC patients.
Sections du résumé
BACKGROUND
BACKGROUND
Radiomic features in pancreatic ductal adenocarcinoma (PDAC) often lack validation in independent test sets or are limited to early or late stage disease. Given the lethal nature of PDAC it is possible that there are similarities in radiomic features of both early and advanced disease reflective of aggressive biology.
PURPOSE
OBJECTIVE
To assess the performance of prognostic radiomic features previously published in patients with resectable PDAC in a test set of patients with unresectable PDAC undergoing chemotherapy.
METHODS
METHODS
The pre-treatment CT of 108 patients enrolled in a prospective chemotherapy trial were used as a test cohort for 2 previously published prognostic radiomic features in resectable PDAC (Sum Entropy and Cluster Tendency with square-root filter[Sqrt]). We assessed the performance of these 2 radiomic features for the prediction of overall survival (OS) and time to progression (TTP) using Cox proportional-hazard models.
RESULTS
RESULTS
Sqrt Cluster Tendency was significantly associated with outcome with a hazard ratio (HR) of 1.27(for primary pancreatic tumor plus local nodes), (Confidence Interval(CI):1.01 -1.6,
CONCLUSION
CONCLUSIONS
The CT radiomic feature Sqrt Cluster Tendency, previously demonstrated to be prognostic in resectable PDAC, remained a significant prognostic factor for OS and TTP in a test set of unresectable PDAC patients. This radiomic feature warrants further investigation to understand its biologic correlates and CT applicability in PDAC patients.
Identifiants
pubmed: 33151087
doi: 10.1177/0846537120968782
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM