The gut mycobiome: a novel player in chronic liver diseases.
Alcohol-associated liver disease
Fungi
Fungome
Microbiome
Non-alcoholic fatty liver disease
Journal
Journal of gastroenterology
ISSN: 1435-5922
Titre abrégé: J Gastroenterol
Pays: Japan
ID NLM: 9430794
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
27
09
2020
accepted:
15
10
2020
pubmed:
6
11
2020
medline:
30
11
2021
entrez:
5
11
2020
Statut:
ppublish
Résumé
The human gut microbiome (bacteria, fungi, viruses, and archaea) is a complex and diverse ecosystem. It plays an important role in human health, but is involved in several intestinal and extraintestinal diseases. Most research to date has focused on the role of bacteria, while studies focusing on fungi (also referred to as "mycobiome" or "fungome") are still in its infancy. In this review, we focus on the existing literature available about the gut mycobiome with an emphasis on compositional mycobiome changes associated with liver diseases, the impact on pathogenesis of disease, and its potential use as therapeutic targets. We also provide insights into current methodologies of studying mycobiome, and we highlight the interkingdom interactions in the context of disease and how they affect health of the host. Herein, by focusing on the gut mycobiome, this review provides novel insights and directions for liver research.
Identifiants
pubmed: 33151407
doi: 10.1007/s00535-020-01740-5
pii: 10.1007/s00535-020-01740-5
pmc: PMC7819863
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-11Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA24726
Pays : United States
Organisme : BLRD VA
ID : I01 BX004594
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK120515
Pays : United States
Organisme : Fond National de Recherche Scientifique Belgium
ID : T.0217.18
Organisme : NIAAA NIH HHS
ID : P50 AA011999
Pays : United States
Organisme : Fond National de Recherche Scientifique Belgium
ID : J.0146.17
Organisme : NIAAA NIH HHS
ID : U01 AA026939
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA020703
Pays : United States
Organisme : Biomedical Laboratory Research and Development, VA Office of Research and Development
ID : BX004594
Organisme : NIAAA NIH HHS
ID : R01AA020703
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA024726
Pays : United States
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