Effects of cardiopulmonary bypass perfusion temperature on perioperative renal function in adult patients undergoing cardiac surgery.
Acute kidney injury
Albuminuria
Cardiac
Cardiopulmonary bypass
Creatinine
Creatinine clearance
Heart valves
Hypothermia
Perfusion cardiac
Journal
Journal of the Saudi Heart Association
ISSN: 1016-7315
Titre abrégé: J Saudi Heart Assoc
Pays: Saudi Arabia
ID NLM: 9887261
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
08
2019
accepted:
29
09
2019
entrez:
6
11
2020
pubmed:
7
11
2020
medline:
7
11
2020
Statut:
epublish
Résumé
The primary objective of this investigation was to study the effects of cardiopulmonary bypass (CPB) perfusion temperature on renal function parameters [serum creatinine, creatinine clearance, urine albumin, urine protein, and urine albumin/creatinine ratio (ACR)]. The secondary objective was to detect renal complications of CPB. This is a prospective longitudinal study of 30 adult patients (17 men, 13 women; mean age, 53.37 ± 16.02 years) who underwent valvular heart surgery [with or without coronary artery bypass grafting (CABG)]. Serum creatinine, creatinine clearance, urine protein, urine albumin, and urine ACR were collected during CPB (at 28 °C, 32 °C, and 37 °C) and postoperatively (at 12 hours, 24 hours, and 48 hours). Data were analyzed using one-way repeated-measures analysis of variance (ANOVA). A significant ANOVA was followed by a Bonferroni-Holm Although serum creatinine ( CPB with moderate hypothermia for valvular heart surgeries can be performed safely in patients with adequate renal functional reserve. The glomerular permeability across the Bowman's capsule increases after CPB as evidenced by significant proteinuria at 12 hours and increased albuminuria at 48 hours after surgery. There is an increased risk of transient stage I AKI after CPB, from which patients recover within 48 hours.
Identifiants
pubmed: 33154890
doi: 10.37616/2212-5043.1007
pii: sha-32-01-040
pmc: PMC7640603
doi:
Types de publication
Journal Article
Langues
eng
Pagination
40-45Informations de copyright
© 2020 Saudi Heart Association.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
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