Neuroanatomical associations of the Edinburgh cognitive and Behavioural ALS screen (ECAS).
Amyotrophic lateral sclerosis
Cognitive impairment
Cognitive screening
DTI
ECAS
TBSS
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
pubmed:
7
11
2020
medline:
21
7
2021
entrez:
6
11
2020
Statut:
ppublish
Résumé
Cognitive impairment is now recognized in a subset of patients with amyotrophic lateral sclerosis (ALS). The objective of the study was to identify group differences and neuroanatomical correlates of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) in participants ALS. Fifty-three ALS patients and 43 healthy controls recruited as a part of our multicentre study (CALSNIC) were administered the ECAS and underwent an MRI scan. Voxel-based morphometry and tract based spatial statistics (TBSS) was performed to identify structural changes and associations with impaired ECAS scores. Lower performance in the ECAS verbal fluency and executive domains were noted in ALS patients as compared to controls (p < 0.01). Extensive white matter degeneration was noted in the corticospinal tract in all ALS patients, while ALS patients with impaired verbal fluency or executive domains (ALS-exi, n = 22), displayed additional degeneration in the corpus callosum, cingulum and superior longitudinal fasciculus as compared to controls (p < 0.05, TFCE corrected). Mild grey matter changes and associations with ECAS verbal fluency or executive performance were noted at lenient statistical thresholds (p < 0.001, uncorrected). Executive impairment was detected using the ECAS in our multicentre sample of Canadian ALS patients. White matter degeneration in motor regions was revealed in ALS patients with extensive spread to frontal regions in the ALS-exi sub-group. Mild associations between ECAS verbal fluency, executive function scores and MRI metrics suggest that reduced performance may be associated with widespread structural integrity.
Identifiants
pubmed: 33155172
doi: 10.1007/s11682-020-00359-7
pii: 10.1007/s11682-020-00359-7
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1641-1654Subventions
Organisme : CIHR
ID : CIHR MOP 123534
Pays : Canada
Organisme : CIHR
ID : CIHR MOP 123534
Pays : Canada
Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
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