Bone regeneration via skeletal cell lineage plasticity: All hands mobilized for emergencies: Quiescent mature skeletal cells can be activated in response to injury and robustly participate in bone regeneration through cellular plasticity.
bone marrow stromal cells (BMSCs)
bone regeneration
cellular plasticity
fracture repair
in vivo cell lineage analysis
mesenchymal stem cells (MSCs)
skeletal stem cells (SSCs)
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
26
07
2020
revised:
16
09
2020
accepted:
24
09
2020
pubmed:
7
11
2020
medline:
19
8
2021
entrez:
6
11
2020
Statut:
ppublish
Résumé
An emerging concept is that quiescent mature skeletal cells provide an important cellular source for bone regeneration. It has long been considered that a small number of resident skeletal stem cells are solely responsible for the remarkable regenerative capacity of adult bones. However, recent in vivo lineage-tracing studies suggest that all stages of skeletal lineage cells, including dormant pre-adipocyte-like stromal cells in the marrow, osteoblast precursor cells on the bone surface and other stem and progenitor cells, are concomitantly recruited to the injury site and collectively participate in regeneration of the damaged skeletal structure. Lineage plasticity appears to play an important role in this process, by which mature skeletal cells can transform their identities into skeletal stem cell-like cells in response to injury. These highly malleable, long-living mature skeletal cells, readily available throughout postnatal life, might represent an ideal cellular resource that can be exploited for regenerative medicine.
Identifiants
pubmed: 33155283
doi: 10.1002/bies.202000202
pmc: PMC7902387
mid: NIHMS1640839
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000202Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE026666
Pays : United States
Organisme : NIDCR NIH HHS
ID : R03 DE027421
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 Wiley Periodicals LLC.
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