Analysis of a within-host HIV/HTLV-I co-infection model with immunity.
CTL-mediated immune response
Global stability
HIV/HTLV-I co-infection
Lyapunov function
Mitotic transmission
Journal
Virus research
ISSN: 1872-7492
Titre abrégé: Virus Res
Pays: Netherlands
ID NLM: 8410979
Informations de publication
Date de publication:
02 04 2021
02 04 2021
Historique:
received:
12
07
2020
revised:
07
10
2020
accepted:
16
10
2020
pubmed:
7
11
2020
medline:
12
4
2022
entrez:
6
11
2020
Statut:
ppublish
Résumé
Human immunodeficiency virus (HIV) and human T-lymphotropic virus type I (HTLV-I) are two retroviruses that attack the immune cells and impair their functions. Both HIV and HTLV-I can be transmitted between individuals through direct contact with certain body fluids from infected individuals. Therefore, a person can be co-infected with both viruses. HIV causes acquired immunodeficiency syndrome, while HTLV-I is the causative agent for adult T-cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. Several mathematical models have been developed in the literature to describe the within-host dynamics of HIV and HTLV-I mono-infections. However, modeling a within-host dynamics of HIV/HTLV-I co-infection has not been involved. In the present paper, we are concerned to formulate and analyze a new HIV/HTLV co-infection model under the effect of Cytotoxic T lymphocytes (CTLs) immune response. The model describes the interaction between susceptible CD4
Identifiants
pubmed: 33157165
pii: S0168-1702(20)31111-4
doi: 10.1016/j.virusres.2020.198204
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
198204Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.