Determinants of plasma fibrin clot lysis measured using three different assays in healthy subjects.
CRP
Clot lysis time
Fibrinolytic capacity
HRG
γ′-Fibrinogen
Journal
Thrombosis research
ISSN: 1879-2472
Titre abrégé: Thromb Res
Pays: United States
ID NLM: 0326377
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
05
04
2020
revised:
26
08
2020
accepted:
10
10
2020
pubmed:
7
11
2020
medline:
22
6
2021
entrez:
6
11
2020
Statut:
ppublish
Résumé
Several methods for measuring fibrinolytic capacity in plasma have been developed yielding frequently inconsistent results. We investigated which factors determine fibrinolytic capacity in three plasma-based assays. In 80 apparently healthy controls (aged 43 ± 10 years, 50 women [62.5%]) we evaluated fibrinolysis using three assays: (1) by Pieters et al. (CLT2018), (2) by Lisman et al. (CLT), and (3) by Carter et al. (Lys50). Coagulation factors and fibrinolytic proteins, including histidine-rich glycoprotein (HRG) and γ'-fibrinogen, were determined. Regression models were performed to identify determinants of lysis times. Positive correlations were observed between CLT2018 and both CLT (r = 0.73) and Lys50 (r = 0.61), as well as between CLT and Lys50 (r = 0.46, all p < 0.001). The main determinants of both CLT2018 and CLT were plasminogen activator inhibitor-1 (PAI-1), followed by thrombin-activatable fibrinolysis inhibitor (TAFI) and α We showed that apart from PAI-1, TAFI, and α
Identifiants
pubmed: 33157491
pii: S0049-3848(20)30558-2
doi: 10.1016/j.thromres.2020.10.014
pii:
doi:
Substances chimiques
Fibrin
9001-31-4
Carboxypeptidase B2
EC 3.4.17.20
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-7Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.