Molecular Features and Targeted Therapies in Extrahepatic Cholangiocarcinoma: Promises and Failures.
biliary tract cancer
cholangiocarcinoma
extrahepatic cholangiocarcinoma
liver cancer
targeted therapies
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
04 Nov 2020
04 Nov 2020
Historique:
received:
27
09
2020
revised:
28
10
2020
accepted:
02
11
2020
entrez:
7
11
2020
pubmed:
8
11
2020
medline:
8
11
2020
Statut:
epublish
Résumé
Biliary tract cancers (BTCs) include a heterogenous group of aggressive malignancies with limited therapeutic options. According to their anatomical location, these hepatobiliary tumors are usually classified into intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma (eCCA), and gallbladder cancer (GBC). Unfortunately, BTCs are often diagnosed when already metastatic, and although the advent of genomic sequencing has led to a deeper understanding of iCCA pathogenesis, very little data are currently available about the molecular landscape of eCCA. Moreover, despite novel systemic treatments emerging in BTC, the grim prognosis of eCCA patients has not changed in the past decade, and no targeted therapies have been approved so far. The aim of the current review is to provide an overview regarding molecular features and potential targeted therapies in eCCA, together with novel therapeutic approaches and future directions of translational and clinical research on this highly aggressive disease that poses many unanswered questions.
Identifiants
pubmed: 33158162
pii: cancers12113256
doi: 10.3390/cancers12113256
pmc: PMC7694193
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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