Multivariate Design of 3D Printed Immediate-Release Tablets with Liquid Crystal-Forming Drug-Itraconazole.
3D printing
fused deposition modeling
hot-melt extrusion
itraconazole
solid dosage forms
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
04 Nov 2020
04 Nov 2020
Historique:
received:
08
10
2020
revised:
26
10
2020
accepted:
02
11
2020
entrez:
7
11
2020
pubmed:
8
11
2020
medline:
8
11
2020
Statut:
epublish
Résumé
The simplicity of object shape and composition modification make additive manufacturing a great option for customized dosage form production. To achieve this goal, the correlation between structural and functional attributes of the printed objects needs to be analyzed. So far, it has not been deeply investigated in 3D printing-related papers. The aim of our study was to modify the functionalities of printed tablets containing liquid crystal-forming drug itraconazole by introducing polyvinylpyrrolidone-based polymers into the filament-forming matrices composed predominantly of poly(vinyl alcohol). The effect of the molecular reorganization of the drug and improved tablets' disintegration was analyzed in terms of itraconazole dissolution. Micro-computed tomography was applied to analyze how the design of a printed object (in this case, a degree of an infill) affects its reproducibility during printing. It was also used to analyze the structure of the printed dosage forms. The results indicated that the improved disintegration obtained due to the use of Kollidon
Identifiants
pubmed: 33158192
pii: ma13214961
doi: 10.3390/ma13214961
pmc: PMC7662355
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Narodowe Centrum Nauki
ID : 2018/31/B/ST8/01327
Références
J Pharm Sci. 2018 Jan;107(1):390-401
pubmed: 29066279
Eur J Pharm Sci. 2018 Oct 15;123:191-198
pubmed: 30031859
Int J Pharm. 2018 May 30;543(1-2):361-367
pubmed: 29605693
Int J Pharm. 2020 Apr 30;580:119200
pubmed: 32156531
Mater Sci Eng C Mater Biol Appl. 2020 Feb;107:110248
pubmed: 31761175
Eur J Pharm Sci. 2020 Apr 30;147:105291
pubmed: 32135271
J Control Release. 2017 Sep 10;261:207-215
pubmed: 28668378
Pharm Res. 2018 Jul 11;35(9):176
pubmed: 29998405
AAPS PharmSciTech. 2018 Nov;19(8):3343-3354
pubmed: 29872975
Eur J Pharm Sci. 2017 Aug 30;106:413-421
pubmed: 28627470
J Pharm Sci. 2019 Apr;108(4):1453-1465
pubmed: 30395834
Pharm Res. 2018 Jan 16;35(2):34
pubmed: 29368113
AAPS PharmSciTech. 2018 Dec 17;20(1):7
pubmed: 30560468
Eur J Pharm Sci. 2019 Jul 1;135:60-67
pubmed: 31108205
Eur J Pharm Sci. 2020 Feb 15;143:105176
pubmed: 31809907
Pharm Res. 2018 Jan 5;35(1):16
pubmed: 29305665
Int J Pharm. 2019 Aug 15;567:118471
pubmed: 31252147
Int J Pharm. 2019 Mar 25;559:299-311
pubmed: 30707934
AAPS PharmSciTech. 2019 Jan 7;20(2):52
pubmed: 30617660
Int J Pharm. 2019 Nov 25;571:118700
pubmed: 31526838
Int J Pharm. 2020 Mar 30;578:119124
pubmed: 32035253
Pharmaceutics. 2020 Jan 17;12(1):
pubmed: 31963484
Sensors (Basel). 2020 Jan 28;20(3):
pubmed: 32012830
J Pharm Sci. 2018 Jan;107(1):286-296
pubmed: 28847477
Pharmaceutics. 2018 Apr 02;10(2):
pubmed: 29614811
Int J Pharm. 2020 Apr 15;579:119169
pubmed: 32087263
Eur J Pharm Sci. 2020 Apr 15;146:105266
pubmed: 32060006
Int J Pharm. 2017 Oct 30;532(1):603-611
pubmed: 28923766
Pharmaceutics. 2020 Jun 03;12(6):
pubmed: 32503216
Int J Pharm. 2018 Oct 25;550(1-2):418-428
pubmed: 30172750
Int J Pharm. 2016 Apr 30;503(1-2):207-12
pubmed: 26976500
Mol Pharm. 2016 Jun 6;13(6):1879-93
pubmed: 27092396
Eur J Pharm Sci. 2018 Jul 30;120:40-52
pubmed: 29678613
Pharmaceutics. 2018 Apr 24;10(2):
pubmed: 29695136
Pharmaceutics. 2019 Jul 14;11(7):
pubmed: 31337146
Int J Pharm. 2017 Nov 30;533(2):413-420
pubmed: 28552800
Int J Pharm. 2020 Jun 30;584:119430
pubmed: 32416133
Int J Pharm. 2018 Jun 15;544(2):425-432
pubmed: 29555437
AAPS PharmSciTech. 2018 Nov;19(8):3333-3342
pubmed: 29855799
Pharmaceutics. 2020 Jan 30;12(2):
pubmed: 32019101
Int J Pharm. 2020 Jun 30;584:119428
pubmed: 32445906
Int J Pharm. 2018 Mar 25;539(1-2):75-82
pubmed: 29366944
Eur J Pharm Sci. 2020 Feb 15;143:105169
pubmed: 31785383
AAPS PharmSciTech. 2018 Nov;19(8):3355-3361
pubmed: 29948979
Pharmaceutics. 2020 Apr 16;12(4):
pubmed: 32316199
Pharmaceutics. 2020 Feb 28;12(3):
pubmed: 32121141
Int J Pharm. 2020 Feb 15;575:118883
pubmed: 31811925
Mol Pharm. 2014 Jan 6;11(1):186-96
pubmed: 24283890
J Pharm Sci. 2020 Jun;109(6):1990-1999
pubmed: 32112824
Chem Pharm Bull (Tokyo). 2019;67(9):992-999
pubmed: 31474738
Drug Deliv Transl Res. 2020 Aug;10(4):986-1001
pubmed: 32207070
Eur J Pharm Biopharm. 2018 Oct;131:44-47
pubmed: 30048746
Int J Pharm. 2019 Sep 10;568:118517
pubmed: 31306713
J Pharm Sci. 2019 Dec;108(12):3859-3869
pubmed: 31542437
Eur J Pharm Sci. 2018 Jan 1;111:482-491
pubmed: 29080855
Pharm Res. 2018 Apr 25;35(7):127
pubmed: 29696402
Pharm Res. 2008 Jun;25(6):1450-9
pubmed: 18288449
Pharm Dev Technol. 2019 Apr;24(4):487-493
pubmed: 30149761
Eur J Pharm Sci. 2013 Feb 14;48(3):371-84
pubmed: 23267847
Int J Pharm. 2019 Jan 30;555:198-206
pubmed: 30458260
Int J Pharm. 2017 Aug 30;529(1-2):285-293
pubmed: 28668582
Eur J Pharm Biopharm. 2019 Feb;135:94-103
pubmed: 30579852
Int J Pharm. 2018 Aug 25;547(1-2):44-52
pubmed: 29787894
J Control Release. 2018 Jan 10;269:355-363
pubmed: 29146240
Pharmaceutics. 2019 Dec 03;11(12):
pubmed: 31816898
J Pharm Sci. 2019 Sep;108(9):3063-3073
pubmed: 31103788