Post liver transplant recurrent and de novo viral infections.
CMV
COVID-19
EBV
HHV-6
HSV
Hepatitis B
Hepatitis C
Hepatitis E
Liver transplantation
Recurrent viral infection
de novo infection
Journal
Best practice & research. Clinical gastroenterology
ISSN: 1532-1916
Titre abrégé: Best Pract Res Clin Gastroenterol
Pays: Netherlands
ID NLM: 101120605
Informations de publication
Date de publication:
Historique:
received:
21
09
2020
accepted:
22
09
2020
entrez:
7
11
2020
pubmed:
8
11
2020
medline:
18
11
2020
Statut:
ppublish
Résumé
Survival following liver transplantation has changed dramatically owing to improvement in surgical techniques, peri-operative care and optimal immunosuppressive therapy. Post-Liver transplant (LT) de novo or recurrent viral infection continues to cause major allograft dysfunction, leading to poor graft and patient survival in untreated patients. Availability of highly effective antiviral drugs has significantly improved post-LT survival. Patients transplanted for chronic hepatitis B infection should receive life-long nucleos(t)ide analogues, with or without HBIg for effective viral control. Patients with chronic hepatitis C should be commenced on directly acting antiviral (DAA) drugs prior to transplantation. DAA therapy for post-LT recurrent hepatitis C infection is associated with close to 100% sustained virological response (SVR), irrespective of genotype. De novo chronic Hepatitis E infection is an increasingly recognised cause of allograft dysfunction in LT recipients. Untreated chronic HEV infection of the graft may lead to liver fibrosis and allograft failure. CMV and EBV can reactivate leading to systemic illness following liver transplantation. With COVID-19 pandemic, post-transplant patients are at risk of SARS-Co-V2 infection. Majority of the LT recipients require hospitalization, and the mortality in this population is around 20%. Early recognition of allograft dysfunction and identification of viral aetiology is essential in the management of post-LT de novo or recurrent infections. Optimising immunosuppression is an important step in reducing the severity of allograft damage in the treatment of post-transplant viral infections. Viral clearance or control can be achieved by early initiation of high potency antiviral therapy.
Identifiants
pubmed: 33158469
pii: S1521-6918(20)30024-X
doi: 10.1016/j.bpg.2020.101689
pmc: PMC7519014
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101689Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.
Références
Clin Transplant. 2000 Apr;14(2):136-8
pubmed: 10770418
Lancet Infect Dis. 2016 Jun;16(6):685-697
pubmed: 26907736
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
J Viral Hepat. 2007 Nov;14 Suppl 1:89-96
pubmed: 17958649
Transpl Int. 2013 Jun;26(6):592-600
pubmed: 23590709
Liver Transpl. 2008 Jan;14(1):100-9
pubmed: 18161770
Hepatology. 1991 Apr;13(4):619-26
pubmed: 2010156
J Hepatol. 2012 Jun;56(6):1310-6
pubmed: 22314429
Transplantation. 2000 Jun 27;69(12):2566-73
pubmed: 10910278
Gastroenterology. 2017 Nov;153(5):1273-1283.e1
pubmed: 28734831
Lancet Gastroenterol Hepatol. 2020 Jul;5(7):649-657
pubmed: 32389183
Clin Transplant. 2016 May;30(5):487-501
pubmed: 26855333
Mayo Clin Proc. 2003 Feb;78(2):197-210
pubmed: 12583530
Clin Microbiol Rev. 1997 Jan;10(1):86-124
pubmed: 8993860
Gastroenterology. 2011 May;140(5):1481-9
pubmed: 21354150
Am J Transplant. 2008 Mar;8(3):679-87
pubmed: 18294165
Liver Transpl. 2010 Nov;16(11):1288-95
pubmed: 21031544
World J Gastroenterol. 2015 Apr 7;21(13):3912-20
pubmed: 25852276
N Engl J Med. 2015 Dec 31;373(27):2599-607
pubmed: 26571066
Clin Infect Dis. 1998 Mar;26(3):702-7
pubmed: 9524848
Liver Transpl. 2006 Jan;12(1):134-9
pubmed: 16382465
Hepatology. 2015 May;61(5):1485-94
pubmed: 25557906
Hepatology. 2016 May;63(5):1493-505
pubmed: 26754432
Liver Transpl. 2007 Sep;13(9):1246-53
pubmed: 17763405
Medicine (Baltimore). 1988 Mar;67(2):132-43
pubmed: 3280944
Gastroenterology. 2007 Mar;132(3):931-7
pubmed: 17383422
J Hepatol. 2016 Feb;64(2):433-485
pubmed: 26597456
J Hepatol. 2012 May;56(5):1063-1069
pubmed: 22245897
Ann Intern Med. 1993 Jan 1;118(1):45-58
pubmed: 8380053
Liver Transpl. 2006 Oct;12(10):1496-503
pubmed: 16964597
J Hepatol. 2020 Nov;73(5):1063-1071
pubmed: 32526252
J Hepatol. 2012 Feb;56(2):500-2
pubmed: 21798217
Clin Gastroenterol Hepatol. 2020 Aug;18(9):2131-2133.e1
pubmed: 32334081
N Engl J Med. 2014 Mar 20;370(12):1111-20
pubmed: 24645943
Gut. 2020 Oct;69(10):1832-1840
pubmed: 32571972
Am J Transplant. 2012 Apr;12(4):976-83
pubmed: 22226225
Liver Transpl. 2016 Apr;22(4):446-58
pubmed: 26890629
Hepatology. 2000 Oct;32(4 Pt 1):852-8
pubmed: 11003634
Liver Transpl. 2007 Nov;13(11):1521-31
pubmed: 17969201
J Med Virol. 2007 Jan;79(1):45-51
pubmed: 17133548
Transplantation. 2004 Nov 27;78(10):1488-95
pubmed: 15599313
Transplantation. 2011 Jan 27;91(2):251-5
pubmed: 21099744
Ther Adv Hematol. 2011 Dec;2(6):393-407
pubmed: 23556105
J Med Virol. 2006 Jun;78(6):800-5
pubmed: 16628583
Hepatology. 2019 Feb;69(2):487-497
pubmed: 28749564
Transplantation. 2011 Jun 15;91(11):1265-72
pubmed: 21478815
Lancet. 2020 May 16;395(10236):1569-1578
pubmed: 32423584
JAMA. 2020 Apr 14;323(14):1378-1387
pubmed: 32286644
Gut. 2006 Mar;55(3):403-8
pubmed: 16020491
J Gen Virol. 1991 Jun;72 ( Pt 6):1401-8
pubmed: 1646280
Transplantation. 2002 Oct 27;74(8):1095-102
pubmed: 12438953
Hepatol Int. 2016 Sep;10(5):749-61
pubmed: 27337961
Am J Transplant. 2004 Apr;4(4):644-9
pubmed: 15023158
J Hepatol. 2012 Apr;56(4):973-83
pubmed: 21963518
Liver Transpl. 2005 Jun;11(6):700-4
pubmed: 15915496
J Viral Hepat. 2004 Mar;11(2):97-107
pubmed: 14996343
Braz J Infect Dis. 2014 Mar-Apr;18(2):220-4
pubmed: 24275367
Pediatr Transplant. 2012 Nov;16(7):742-7
pubmed: 22738211
BMC Infect Dis. 2015 Sep 02;15:371
pubmed: 26328802
J Hepatol. 2020 Nov;73(5):1231-1240
pubmed: 32553666
Lancet Gastroenterol Hepatol. 2020 Jul;5(7):643-644
pubmed: 32339474
Transplantation. 2000 Jun 27;69(12):2561-6
pubmed: 10910277
Am J Clin Pathol. 2013 Sep;140(3):403-9
pubmed: 23955460
Lancet. 1997 Dec 13;350(9093):1729-33
pubmed: 9413463
Emerg Infect Dis. 2011 Jan;17(1):30-7
pubmed: 21192851
World J Gastroenterol. 2016 Mar 7;22(9):2844-54
pubmed: 26973423
Transpl Int. 2020 Oct;33(10):1244-1252
pubmed: 32609908
J Hepatol. 2000 Apr;32(4):673-84
pubmed: 10782918
Curr Opin Organ Transplant. 2017 Apr;22(2):123-127
pubmed: 28151809
Eur Neurol. 2002;48(4):234-5
pubmed: 12422078
Transplantation. 1998 May 15;65(9):1178-82
pubmed: 9603164
Br J Haematol. 2010 Jun;149(5):675-92
pubmed: 20408847
Transpl Infect Dis. 2012 Oct;14(5):479-87
pubmed: 22624695
Ann Surg Treat Res. 2015 Sep;89(3):145-50
pubmed: 26366384
Am J Transplant. 2013 Mar;13 Suppl 4:107-20
pubmed: 23465004
Transpl Infect Dis. 2015 Oct;17(5):695-701
pubmed: 26257166
J Hepatol. 1992 Jan;14(1):104-11
pubmed: 1737910
Am J Transplant. 2013 Mar;13 Suppl 4:121-7
pubmed: 23465005
Transplant Proc. 2012 Oct;44(8):2455-8
pubmed: 23026619
Antimicrob Agents Chemother. 1995 Dec;39(12):2759-64
pubmed: 8593015
Hepatol Int. 2020 Dec;14(6):1125-1127
pubmed: 32990918
N Engl J Med. 2008 Feb 21;358(8):811-7
pubmed: 18287603
J Hepatol. 2016 Jun;64(6):1224-31
pubmed: 26829205
Indian J Gastroenterol. 2013 Mar;32(2):71-9
pubmed: 23054947
Liver Transpl. 2013 Jun;19(6):594-601
pubmed: 23447407
Herpes. 2004 Dec;11(3):77-86
pubmed: 15960905
J Hepatol. 2014 Nov;61(1 Suppl):S58-68
pubmed: 25443346
Clin Microbiol Rev. 2010 Oct;23(4):689-712
pubmed: 20930070
Transplantation. 2009 Oct 15;88(7):926-34
pubmed: 19935465
Arch Virol. 2014 May;159(5):863-70
pubmed: 24193951
Liver Transpl. 2003 Nov;9(11):S48-51
pubmed: 14586895
Transplantation. 2002 Feb 27;73(4):599-604
pubmed: 11889438
Transplantation. 2002 Feb 15;73(3):481-2
pubmed: 11884950
J Infect Dis. 2003 Jun 1;187(11):1801-8
pubmed: 12751039
Pediatr Transplant. 2003 Apr;7(2):125-9
pubmed: 12654053
J Infect Dis. 2002 Oct 15;186 Suppl 1:S3-28
pubmed: 12353183
PLoS One. 2014 Sep 08;9(9):e107057
pubmed: 25198195
Hepatology. 2006 Mar;43(3):492-9
pubmed: 16496308
Hepatology. 2002 Mar;35(3):680-7
pubmed: 11870384
J Hepatol. 2004 Nov;41(5):830-6
pubmed: 15519657
Ann Intern Med. 1985 Jun;102(6):783-5
pubmed: 2986508
Transplant Proc. 1991 Feb;23(1 Pt 2):1448-51
pubmed: 1989260
Transplant Proc. 2012 Jul-Aug;44(6):1475-8
pubmed: 22841188
Dig Dis. 2017;35(4):347-350
pubmed: 28468002
J Hepatol. 2012 Jan;56(1):115-22
pubmed: 21762665
Hepatology. 2017 Mar;65(3):804-812
pubmed: 28012259
Liver Transpl. 2010 Mar;16(3):300-7
pubmed: 20209589
Eur J Gastroenterol Hepatol. 2006 Oct;18(10):1065-70
pubmed: 16957512
Gastroenterology. 2016 Jan;150(1):82-85.e4
pubmed: 26408347
World J Gastroenterol. 2016 Sep 14;22(34):7824-40
pubmed: 27678366
N Engl J Med. 2008 Aug 7;359(6):593-602
pubmed: 18687640
J Infect Dis. 1989 Nov;160(5):752-8
pubmed: 2553824
Hepatol Int. 2020 Sep;14(5):690-700
pubmed: 32623632
N Engl J Med. 1993 Dec 16;329(25):1842-7
pubmed: 8247035
Curr Opin Organ Transplant. 2011 Jun;16(3):274-80
pubmed: 21467936
Am J Transplant. 2005 May;5(5):1065-70
pubmed: 15816887
J Viral Hepat. 2016 Jun;23(6):408-18
pubmed: 27018088
Gastroenterology. 2015 Sep;149(3):649-59
pubmed: 25985734
Liver Transpl. 2001 Feb;7(2):75-81
pubmed: 11172388
Liver Transpl. 2007 Jun;13(6):904-12
pubmed: 17539010
Lancet Gastroenterol Hepatol. 2020 Jun;5(6):532-533
pubmed: 32278366
Hepatology. 1999 Jan;29(1):250-6
pubmed: 9862874
Transpl Infect Dis. 2015 Oct;17(5):671-8
pubmed: 26201686
Liver Transpl. 2001 Jun;7(6):513-7
pubmed: 11443579
Am J Transplant. 2013 Mar;13 Suppl 4:93-106
pubmed: 23465003
Lancet. 1988 Aug 6;2(8606):302-5
pubmed: 2899720
J Hepatol. 2006 Apr;44(4):717-22
pubmed: 16487616
Clin Gastroenterol Hepatol. 2020 Mar;18(3):747-749
pubmed: 31271737
Gastroenterology. 2015 Jan;148(1):100-107.e1
pubmed: 25261839
Pathog Glob Health. 2013 Sep;107(6):312-9
pubmed: 24188241
Clin Liver Dis. 2014 Aug;18(3):575-601
pubmed: 25017077
Liver Transpl. 2004 Sep;10(9):1140-3
pubmed: 15350004
Liver Transpl. 2016 Mar;22(3):279-80
pubmed: 26663608
Drugs. 2010 May 28;70(8):965-81
pubmed: 20481654
Dig Liver Dis. 2014 Oct;46(10):923-7
pubmed: 24997638
Liver Transpl. 2009 Oct;15(10):1225-8
pubmed: 19790147
FEMS Microbiol Rev. 2018 Mar 1;42(2):137-145
pubmed: 29361041
Liver Transpl. 2009 Jul;15(7):709-18
pubmed: 19562704
Gastroenterology. 2015 Jan;148(1):108-17
pubmed: 25304641
J Clin Virol. 2011 May;51(1):20-4
pubmed: 21376662
J Clin Microbiol. 2002 Jan;40(1):117-22
pubmed: 11773103
Clin Microbiol Rev. 2005 Jan;18(1):217-45
pubmed: 15653828
J Hepatol. 2020 Sep;73(3):696-699
pubmed: 32624195
J Infect Dis. 1988 Jul;158(1):124-31
pubmed: 2839576
Liver Int. 2018 Feb;38(2):210-223
pubmed: 28650593
Am J Transplant. 2020 Jul;20(7):1800-1808
pubmed: 32330343
Hepatology. 2008 Aug;48(2):418-31
pubmed: 18563841
J Clin Exp Hepatol. 2017 Jun;7(2):144-151
pubmed: 28663679
Swiss Med Wkly. 2005 Oct 1;135(39-40):571-3
pubmed: 16333768
Liver Transpl. 2013 Sep;19(9):1030-5
pubmed: 23788470
Transplantation. 2018 Jun;102(6):900-931
pubmed: 29596116
Lancet Oncol. 2012 Feb;13(2):196-206
pubmed: 22173060
Gastroenterology. 2016 Feb;150(2):355-7.e3
pubmed: 26551551
Exp Clin Transplant. 2016 Aug;14(4):361-6
pubmed: 27041365
Semin Liver Dis. 2004;24 Suppl 2:79-88
pubmed: 15346250
Transpl Immunol. 2010 Aug;23(4):166-9
pubmed: 20609386
Am J Transplant. 2008 May;8(5):1016-24
pubmed: 18312608
Am J Transplant. 2013 Mar;13 Suppl 4:138-46
pubmed: 23465007
Am J Transplant. 2010 May;10(5):1228-37
pubmed: 20353469