Effect of high-intensity focused ultrasound (HiFU) treatment on intraocular pressure and aqueous humour dynamics: 12 -months results.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
19
05
2020
accepted:
22
10
2020
revised:
10
09
2020
pubmed:
8
11
2020
medline:
21
9
2021
entrez:
7
11
2020
Statut:
ppublish
Résumé
High intensity focused ultrasound (HiFU) is a cyclodestructive therapy for controlling intraocular pressure (IOP) in glaucoma. The mechanism of action is thought to be through destruction of the ciliary epithelium as well as increased uveoscleral outflow. We reviewed the change in aqueous humour dynamics parameters including aqueous humour flow rate, tonographic outflow facility (TOF) and uveoscleral outflow at 12 months. This is a prospective observational study. Consecutive patients with open angle glaucoma (OAG) or ocular hypertension (OHT) requiring further IOP lowering were enroled in the study between August 2016 and January 2017. Patients were commenced on medication washout period prior to baseline and twelve months' visit. Sixteen patients (OAG) in the treatment group underwent assessment at twelve months follow up. Mean age was 63.1 ± 11 years. Eleven patients were African/Caribbean and 5 were Caucasian. Nine patients were female and 7 were male. Mean post-washout IOP was reduced by 21% (28.3 ± 5.7 at baseline vs 22.4 ± 8.4 mmHg at 12 months, p = 0.04). Aqueous humour flow rate was reduced by 16% at twelve months (2.40 ± 0.6 at baseline vs 2.02 ± 0.6 µl/min at 12 months, p = 0.0493). There was no statistically significant change in the TOF (0.12 ± 0.09 at baseline vs 0.08 ± 0.05 µl/min/mmHg at 12 months, p = 0.08) or uveoscleral outflow (0.6 ± 1.3 at baseline vs 1.3 ± 0.85 µl/min at 12 months, p = 0.15). In this study, we demonstrated that the observed IOP reduction was likely due to aqueous humour flow rate reduction. The TOF and uveoscleral outflow were not detectibly changed.
Identifiants
pubmed: 33159175
doi: 10.1038/s41433-020-01260-9
pii: 10.1038/s41433-020-01260-9
pmc: PMC8377105
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2499-2505Subventions
Organisme : Medical Research Council
ID : MR/T027932/1
Pays : United Kingdom
Informations de copyright
© 2020. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.
Références
Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121:2081–90.
doi: 10.1016/j.ophtha.2014.05.013
Gaasterland DE, Ederer F, Beck A, Costarides A, Leef D, Closek J, et al. The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol. 2000;130:429–40.
Miglior S, Bertuzzi F. Relationship between intraocular pressure and glaucoma onset and progression. Curr Opin Pharmacol. 2013;13:32–35.
doi: 10.1016/j.coph.2012.09.014
Fankhauser F, Kwasniewska S, Van Der Zypen E. Cyclodestructive procedures - I. Clinical and morphological aspects: a review. Ophthalmologica. 2004;218:77–95.
doi: 10.1159/000076142
Dastiridou AI, Katsanos A, Denis P, Francis BA, Mikropoulos DG, Teus MA, et al. cyclodestructive procedures in glaucoma: a review of current and emerging options. Adv Ther. 2018;35:2103–27.
doi: 10.1007/s12325-018-0837-3
Michelessi M, Bicket AK, Lindsley K. Cyclodestructive procedures for non-refractory glaucoma. Cochrane Database Syst. Rev. 2018;4:CD009313.
Kosoko O, Gaasterland DE, Pollack IP, Enger CL. Long-term outcome of initial ciliary ablation with contact diode laser transscleral cyclophotocoagulation for severe glaucoma. Ophthalmology. 1996;103:1294–302.
doi: 10.1016/S0161-6420(96)30508-3
Posarelli C, Covello G, Bendinelli A, Fogagnolo P, Nardi M, Figus M. High-intensity focused ultrasound procedure: the rise of a new noninvasive glaucoma procedure and its possible future applications. Surv Ophthalmol 2019;64:826–34.
doi: 10.1016/j.survophthal.2019.05.001
Mastropasqua R, Fasanella V, Mastropasqua A, Ciancaglini M, Agnifili L. High-intensity focused ultrasound circular cyclocoagulation in glaucoma: a step forward for cyclodestruction? J Ophthalmol. 2017;2017:14.
doi: 10.1155/2017/7136275
Giannaccare G, Vagge A, Sebastiani S, Urbini LE, Corazza P, Pellegrini M, et al. Ultrasound cyclo-plasty in patients with glaucoma: 1-year results from a multicentre prospective study. Ophthalmic Res. 2019;61:137–42.
doi: 10.1159/000487953
Melamed S, Goldenfeld M, Cotlear D, Skaat A, Moroz I. High-intensity focused ultrasound treatment in refractory glaucoma patients: Results at 1 year of prospective clinical study. Eur J Ophthalmol. 2015;25:483–9.
doi: 10.5301/ejo.5000620
Charrel T, Aptel F, Birer A, Chavrier F, Romano F, Chapelon JY, et al. Development of a miniaturized HIFU device for glaucoma treatment with conformal coagulation of the ciliary bodies. Ultrasound Med Biol. 2011;37:742–54.
doi: 10.1016/j.ultrasmedbio.2011.01.017
Aptel F, Charrel T, Palazzi X, Chapelon JY, Denis P, Lafon C. Histologic effects of a new device for High-Intensity focused Ultrasound Cyclocoagulation. Investig. Ophthalmol Vis Sci. 2010;51:5092–8.
doi: 10.1167/iovs.09-5135
Denis P, Aptel F, Rouland JF, Nordmann JP, Lachkar Y, Renard JP, et al. Cyclocoagulation of the ciliary bodies by high-intensity focused ultrasound: a 12-month multicenter study. Investig Ophthalmol Vis Sci. 2015;56:1089–96.
doi: 10.1167/iovs.14-14973
Mastropasqua R, Agnifili L, Fasanella V, Toto L, Brescia L, DI Staso S, et al. Uveo-scleral outflow pathways after ultrasonic cyclocoagulation in refractory glaucoma: an anterior segment optical coherence tomography and in vivo confocal study. Br J Ophthalmol. 2016;100:1668–75.
doi: 10.1136/bjophthalmol-2015-308069
Coleman DJ, Silverman RH, Ursea R, Rondeau MJ, Lizzi FL. Ultrasonically induced hyperthermia for adjunctive treatment of intraocular malignant melanoma. Retina. 1997;17:109–17.
doi: 10.1097/00006982-199703000-00005
Alaghband P, Galvis E, Ramirez A, Madekurozwa M, Chu B, Overby D, et al. The effect of high-intensity focused ultrasound on aqueous humor dynamics in patients with glaucoma. Ophthalmol Glaucoma. 2020;3:122–9.
doi: 10.1016/j.ogla.2019.12.002
Friedenwald JS Standardization of tonometers: Decennial report by the Committee on Standardization of Tonometers. In: American Academy of Ophthalmology and Otolaryngology.; 1954. pp. 266–72.
Alaghband P, Baneke A, Galvis E, Madekurozwa M, Chu B, Overby D, et al. Aqueous humor dynamics in uveitis: A comparative study in hypertensive uveitis. Investig Ophthalmol Vis Sci. 2017;208:347–55.
Johnson M, McLaren JW, Overby DR. Unconventional aqueous humor outflow: a review. Exp Eye Res. 2017;158:94–111.
doi: 10.1016/j.exer.2016.01.017
Sit AJ, McLaren JW. Measurement of episcleral venous pressure. Exp Eye Res. 2011;93:291–8.
doi: 10.1016/j.exer.2011.05.003
Brubaker RF, McLaren JW. Uses of fluorophotometry in glaucoma research. Ophthalmology. 1985;92:884–90.
doi: 10.1016/S0161-6420(85)33939-8
Graber M, Rothschild PR, Khoueir Z, Bluwol E, Benhatchi N, Lachkar Y. High intensity focused ultrasound cyclodestruction versus cyclodiode treatment of refractory glaucoma: a retrospective comparative study. J Fr Ophtalmol. 2018;41:611–8.
doi: 10.1016/j.jfo.2018.02.005
Marques RE, Sousa DC, Vandewalle E, Somers A, Melamed S, Nardi M, et al. The effect of glaucoma treatment using high-intensity focused ultrasound on total and corneal astigmatism: a prospective multicentre study. Acta Ophthalmol. 2020. https://doi.org/10.1111/aos.14467 . Online ahead of print.
Denis P, Aptel F, Rouland JF, Nordmann JP, Lachkar Y, Renard JP, et al. Cyclocoagulation of the ciliary bodies by high-intensity focused ultrasound: a 12-month multicenter study. Investig Ophthalmol Vis Sci. 2015;56:1089–96.
doi: 10.1167/iovs.14-14973
Aptel F, Lafon C. Treatment of glaucoma with high intensity focused ultrasound. Int J Hyperth. 2015;31:292–301.
doi: 10.3109/02656736.2014.984777
Aptel F, Béglé A, Razavi A, Romano F, Charrel T, Chapelon JY, et al. Short- and long-term effects on the ciliary body and the aqueous outflow pathways of high-intensity focused ultrasound cyclocoagulation. Ultrasound Med Biol. 2014;40:2096–106.
doi: 10.1016/j.ultrasmedbio.2014.04.017
Liu GJ, Mizukawa A, Okisaka S. Mechanism of intraocular pressure decrease after contact transscleral continuous-wave Nd:YAG laser cyclophotocoagulation. Ophthalmic Res. 1994;26:65–79.
doi: 10.1159/000267395
Ho CL, Wong EYM, Chew PTK. Effect of diode laser contact transscleral pars plana photocoagulation on intraocular pressure in glaucoma. Clin Exp Ophthalmol. 2002;30:343–7.
doi: 10.1046/j.1442-9071.2002.00553.x
Aptel F, Denis P, Rouland J, Nordmann J, Lachkar Y, Renard J, et al. Ultrasonic circular cyclo coagulation in patients with primary open-angle glaucoma: a multicenter clinical trial. Acta Ophthalmol. 2013;91:252–8.
Aptel F, Denis P, Rouland JF, Renard JP, Bron A. Multicenter clinical trial of high-intensity focused ultrasound treatment in glaucoma patients without previous filtering surgery. Acta Ophthalmol. 2016;94:268–77.
doi: 10.1111/aos.12913
Ye C, Wang XY, Bian XQ, Liang YB. High-intensity focused ultrasound in the treatment of glaucoma. Zhonghua Yan Ke Za Zhi 2020;56:66–70.
pubmed: 31937066
Marques RE, Ferreira NP, Sousa DC, Barata AD, Sens P, Marques-Neves C, et al. High intensity focused ultrasound for glaucoma: 1-year results from a prospective pragmatic study. Eye. 2020. https://pubmed.ncbi.nlm.nih.gov/32317796 / (Accessed October 21, 2020).
Aptel F, Tadjine M, Rouland JF. Efficacy and safety of repeated ultrasound cycloplasty procedures in patients with early or delayed failure after a first procedure. J Glaucoma. 2020;29:24–30. https://doi.org/10.1097/IJG.0000000000001400 .