Leptin receptor, a surface marker for a subset of highly engrafting long-term functional hematopoietic stem cells.
Animals
Biomarkers
/ metabolism
Bone Marrow
/ metabolism
Bone Marrow Cells
/ metabolism
Female
Hematopoiesis
/ physiology
Hematopoietic Stem Cells
/ metabolism
Humans
Interferon Type I
/ metabolism
Interferon-gamma
/ metabolism
Male
Mice
Mice, Inbred C57BL
Receptors, Leptin
/ metabolism
Stem Cell Niche
/ physiology
Stromal Cells
/ metabolism
Journal
Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
31
07
2020
accepted:
24
10
2020
revised:
08
10
2020
pubmed:
8
11
2020
medline:
17
8
2021
entrez:
7
11
2020
Statut:
ppublish
Résumé
The hematopoietic system is sustained by a rare population of hematopoietic stem cells (HSCs), which emerge during early embryonic development and then reside in the hypoxic niche of the adult bone marrow microenvironment. Although leptin receptor (Lepr)-expressing stromal cells are well-studied as critical regulators of murine hematopoiesis, the biological implications of Lepr expression on HSCs remain largely unexplored. We hypothesized that Lepr
Identifiants
pubmed: 33159180
doi: 10.1038/s41375-020-01079-z
pii: 10.1038/s41375-020-01079-z
pmc: PMC8102644
mid: NIHMS1671724
doi:
Substances chimiques
Biomarkers
0
Interferon Type I
0
Receptors, Leptin
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2064-2075Subventions
Organisme : NCI NIH HHS
ID : P30 CA082709
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL139599
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK106846
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007519
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109188
Pays : United States
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