Plasma lipidomics of monozygotic twins discordant for multiple sclerosis.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
28
05
2020
revised:
07
09
2020
accepted:
18
09
2020
pubmed:
8
11
2020
medline:
3
11
2021
entrez:
7
11
2020
Statut:
ppublish
Résumé
Blood biomarkers of multiple sclerosis (MS) can provide a better understanding of pathophysiology and enable disease monitoring. Here, we performed quantitative shotgun lipidomics on the plasma of a unique cohort of 73 monozygotic twins discordant for MS. We analyzed 243 lipid species, evaluated lipid features such as fatty acyl chain length and number of acyl chain double bonds, and detected phospholipids that were significantly altered in the plasma of co-twins with MS compared to their non-affected siblings. Strikingly, changes were most prominent in ether phosphatidylethanolamines and ether phosphatidylcholines, suggesting a role for altered lipid signaling in the disease.
Identifiants
pubmed: 33159711
doi: 10.1002/acn3.51216
pmc: PMC7732246
doi:
Substances chimiques
Biomarkers
0
Phosphatidylcholines
0
Phosphatidylethanolamines
0
Phospholipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2461-2466Informations de copyright
© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
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