A child with acute myeloid leukemia complicated by calcaneal osteomyelitis due to Mycobacterium abscessus infection after induction chemotherapy successfully salvaged with bedaquiline and clofazimine.
Anti-Bacterial Agents
/ therapeutic use
Child, Preschool
Clofazimine
/ therapeutic use
Combined Modality Therapy
Diarylquinolines
/ therapeutic use
Drug Therapy, Combination
Female
Humans
Immunocompromised Host
Induction Chemotherapy
Leukemia, Myeloid, Acute
/ complications
Mycobacterium Infections, Nontuberculous
/ drug therapy
Osteomyelitis
/ drug therapy
Salvage Therapy
leukemia
non-tuberculous Mycobacteria
osteomyelitis
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
22
09
2020
revised:
29
10
2020
accepted:
30
10
2020
pubmed:
8
11
2020
medline:
31
3
2021
entrez:
7
11
2020
Statut:
ppublish
Résumé
Our patient was a 4-year-old female with acute myeloid leukemia complicated with right calcaneal osteomyelitis due to Mycobacterium abscessus with subcutaneous abscesses extending to the popliteal and groin regions after two courses of induction chemotherapy according to NOPHO-AML 2012 protocol. She required multiple operations and prolonged anti-mycobacterial therapy. A high index of suspicion for mycobacterial infection is required for immunocompromised patients with prolonged fever or unusual presentation. Mycobacterial osteomyelitis is rare, difficult to diagnose and treat, and may necessitate prolonged interruption of anti-leukemic therapy. Multidisciplinary collaboration in patient management is crucial. Long-term toxicity of antimicrobials with uncertain efficacy should not be overlooked.
Identifiants
pubmed: 33160065
pii: S1201-9712(20)32306-7
doi: 10.1016/j.ijid.2020.10.102
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Diarylquinolines
0
bedaquiline
78846I289Y
Clofazimine
D959AE5USF
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-12Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.