Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples.
Flavanones
Tanzania
Trypanosomiasis
Zambia
Journal
International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
28
06
2020
revised:
28
10
2020
accepted:
29
10
2020
pubmed:
8
11
2020
medline:
21
8
2021
entrez:
7
11
2020
Statut:
ppublish
Résumé
A bioassay-guided phytochemical investigation of propolis samples from Tanzania and Zambia that screened for activity against Trypanosoma brucei has led to the isolation of two novel flavanones with promising antitrypanosomal activity. The compounds were characterized based on their spectral and physical data and identified as 6-(1,1-dimethylallyl) pinocembrin and 5-hydroxy-4″,4″-dimethyl-5″-methyl-5″-H-dihydrofuranol [2″,3″,6,7] flavanone. The two compounds, together with the propolis extracts and fractions, were assayed against a standard drug-sensitive strain of T. b. brucei (s427 wild-type), multi-drug resistant-resistant T. b. brucei (B48), drug-sensitive T. congolense (1L300) and a derived diminazene-resistant T. congolense strain (6C3), and for toxicity against U947 human cells and RAW 246.7 murine cells. Activity against T. b. brucei was higher than against T. congolense. Interestingly, the Tanzanian propolis extract was found to be more active than its fractions and purified compounds in these assays, with an IC
Identifiants
pubmed: 33160277
pii: S2211-3207(20)30042-7
doi: 10.1016/j.ijpddr.2020.10.011
pmc: PMC7649109
pii:
doi:
Substances chimiques
Antiprotozoal Agents
0
Flavanones
0
Trypanocidal Agents
0
Propolis
9009-62-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
201-207Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
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