Optimization of preparation methods for high loading content and high encapsulation efficiency of BSH into liposomes.

Animals Borohydrides / administration & dosage Boron Neutron Capture Therapy / methods Liposomes Mice Sulfhydryl Compounds / administration & dosage
Boron neutron capture therapy (BNCT) Liposome Mercaptoundecahydrododecaborate (BSH)

Journal

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
ISSN: 1872-9800
Titre abrégé: Appl Radiat Isot
Pays: England
ID NLM: 9306253

Informations de publication

Date de publication:
Mar 2021
Historique:
received: 31 08 2019
revised: 15 05 2020
accepted: 01 06 2020
pubmed: 9 11 2020
medline: 29 10 2021
entrez: 8 11 2020
Statut: ppublish

Résumé

To optimize the preparation methods for liposomes encapsulating mercaptoundecahydrododecaborate (BSH), we examined BSH and lipid concentrations that increased the boron content in liposomes. We improved the BSH encapsulation efficiency and boron content of the liposomes from 4.2 to 45.9 % and 9.5-54.3 μg, respectively, by changing the lipid concentration from 10 to 150 mg/mL. Notably, the boron content increased significantly from 26.2 μg to 326.3 μg at a constant lipid concentration of 30 mg/mL with increased BSH concentrations.

Identifiants

DOI: 10.1016/j.apradiso.2020.109260 PMID: 33160809
pubmed: 33160809
pii: S0969-8043(20)30410-3
doi: 10.1016/j.apradiso.2020.109260
pii:
doi:

Substances chimiques

Borohydrides 0
Liposomes 0
Sulfhydryl Compounds 0
mercaptoundecahydrododecaborate 12294-22-3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109260

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Makoto Shirakawa (M)

Department of Pharmaceutical Sciences, Fukuyama University, 1-985 Higashimuracho-Sanzo, Fukuyama, Hiroshima, 729-0292, Japan; Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. Electronic address: m-shirakawa@fukuyama-u.ac.jp.

Kei Nakai (K)

Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. Electronic address: kenakai-nsu@umin.ac.jp.

Yuhki Sato (Y)

Department of Pharmaceutical Sciences, Fukuyama University, 1-985 Higashimuracho-Sanzo, Fukuyama, Hiroshima, 729-0292, Japan. Electronic address: s-yuhki@fukuyama-u.ac.jp.

Shunji Nakamura (S)

Department of Pharmaceutical Sciences, Fukuyama University, 1-985 Higashimuracho-Sanzo, Fukuyama, Hiroshima, 729-0292, Japan.

Mari Harada (M)

Department of Pharmaceutical Sciences, Fukuyama University, 1-985 Higashimuracho-Sanzo, Fukuyama, Hiroshima, 729-0292, Japan.

Kazuki Ishihara (K)

Department of Pharmaceutical Sciences, Fukuyama University, 1-985 Higashimuracho-Sanzo, Fukuyama, Hiroshima, 729-0292, Japan. Electronic address: p7116009@fukuyama-u.ac.jp.

Fumiyo Yoshida (F)

Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. Electronic address: yoshida.fumiyo.ff@u.tsukuba.ac.jp.

Akira Matsumura (A)

Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. Electronic address: matsumura.akira.ft@alumni.tsukuba.ac.jp.

Hisao Tomida (H)

Department of Pharmaceutical Sciences, Fukuyama University, 1-985 Higashimuracho-Sanzo, Fukuyama, Hiroshima, 729-0292, Japan. Electronic address: tomidahi@hi3.enjoy.ne.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Optimization of preparation methods for high...
questionsmedicales.fr › Composés chimiques organiques › Composés du bore › Boranes › Tétrahydroborates › Optimization of preparation methods for high...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie de haute énergie › Thérapie par capture de neutrons › Thérapie par capture de neutrons par le bore › Optimization of preparation methods for high...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Optimization of preparation methods for high...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Optimization of preparation methods for high...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiols › Optimization of preparation methods for high...