Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes.
nanomaterials
type 1 diabetes
type 2 diabetes
β cell dysfunction
β cell imaging
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
17
06
2020
revised:
23
09
2020
accepted:
12
10
2020
pubmed:
9
11
2020
medline:
3
11
2021
entrez:
8
11
2020
Statut:
ppublish
Résumé
A common feature in the pathophysiology of different types of diabetes is the reduction of β cell mass and/or impairment of β cell function. Diagnosis and treatment of type 1 and type 2 diabetes is currently hampered by a lack of reliable techniques to restore β cell survival, to improve insulin secretion, and to quantify β cell mass in patients. Current new approaches may allow us to precisely and specifically visualize β cells in vivo and provide viable therapeutic strategies to preserve, recover, and regenerate β cells. In this review, we discuss recent protective approaches for β cells and the advantages and limitations of current imaging probes in the field.
Identifiants
pubmed: 33160815
pii: S1043-2760(20)30199-5
doi: 10.1016/j.tem.2020.10.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
905-917Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.