Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy.
Academic Medical Centers
/ organization & administration
Adult
Aged
Aged, 80 and over
COVID-19
/ complications
Female
Humans
Italy
/ epidemiology
Male
Middle Aged
Prevalence
Retrospective Studies
Statistics, Nonparametric
Tertiary Care Centers
/ organization & administration
Venous Thromboembolism
/ epidemiology
Anticoagulants
Pulmonary embolism
SARS-CoV-2
Thrombosis
Journal
Internal and emergency medicine
ISSN: 1970-9366
Titre abrégé: Intern Emerg Med
Pays: Italy
ID NLM: 101263418
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
17
07
2020
accepted:
22
10
2020
pubmed:
9
11
2020
medline:
10
8
2021
entrez:
8
11
2020
Statut:
ppublish
Résumé
Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, the magnitude of this association still needs to be defined. Furthermore, clinical predictors of thrombogenesis, and the relationship with the inflammatory status are currently unknown. On this basis, we conducted a retrospective, observational study on 259 consecutive COVID-19 patients admitted to an academic tertiary referral hospital in Northern Italy between March 19th and April 6th, 2020. Records of COVID-19 patients with a definite VTE event were reviewed for demographic information, co-morbidities, risk factors for VTE, laboratory tests, and anticoagulation treatment. Twenty-five cases among 259 COVID-19 patients developed VTE (9.6%), all of them having a Padua score > 4, although being under standard anticoagulation prophylaxis since hospital admission. In the VTE subcohort, we found a significant positive correlation between platelet count (PLT) and either C reactive protein (CRP) (p < 0.0001) or lactate dehydrogenase (LDH) (p = 0.0013), while a significant inverse correlation was observed between PLT and mean platelet volume (p < 0.0001). Platelet-to-lymphocyte ratio significantly correlated with CRP (p < 0.0001). The majority of VTE patients was male and younger compared to non-VTE patients (p = 0.002 and p = 0.005, respectively). No significant difference was found in D-dimer levels between VTE and non VTE patients, while significantly higher levels of LDH (p = 0.04) and IL-6 (p = 0.04) were observed in VTE patients in comparison to non-VTE patients. In conclusion, our findings showed a quite high prevalence of VTE in COVID-19 patients. Raised inflammatory indexes and increased serum levels of pro-inflammatory cytokines should raise the clinical suspicion of VTE.
Identifiants
pubmed: 33161478
doi: 10.1007/s11739-020-02550-6
pii: 10.1007/s11739-020-02550-6
pmc: PMC7648897
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1141-1152Investigateurs
Nicola Aronico
(N)
Gaetano Bergamaschi
(G)
Giampiera Bertolino
(G)
Silvia Codega
(S)
Filippo Costanzo
(F)
Roberto Cresci
(R)
Angela Delliponti
(A)
Giuseppe Derosa
(G)
Michele Di Stefano
(M)
Francesco Falaschi
(F)
Carmine Iadarola
(C)
Elisabetta Lovati
(E)
Pietro Carlo Lucotti
(PC)
Alessandra Martignoni
(A)
Caterina Mengoli
(C)
Emanuela Miceli
(E)
Amedeo Mugellini
(A)
Chiara Muggia
(C)
Elisabetta Pagani
(E)
Ilaria Palumbo
(I)
Alessandro Pecci
(A)
Tiziano Perrone
(T)
Carmelo Sgarlata
(C)
Luisa Siciliani
(L)
Andrea Staniscia
(A)
Francesca Torello Vjera
(FT)
Giovanna Achilli
(G)
Andrea Agostinelli
(A)
Valentina Antoci
(V)
Alessia Ballesio
(A)
Francesco Banfi
(F)
Chiara Barteselli
(C)
Irene Benedetti
(I)
Federica Borrelli de Andreis
(FB)
Michele Brattoli
(M)
Francesca Calabretta
(F)
Ginevra Cambiè
(G)
Roberta Canta
(R)
Federico Conca
(F)
Luigi Coppola
(L)
Elisa Maria Cremonte
(EM)
Gabriele Croce
(G)
Virginia Del Rio
(V)
Francesco Di Terlizzi
(F)
Maria Giovanna Ferrari
(MG)
Sara Ferrari
(S)
Anna Fiengo
(A)
Tommaso Forni
(T)
Chiara Frigerio
(C)
Alessandra Fusco
(A)
Margherita Gabba
(M)
Matteo Garolfi
(M)
Antonella Gentile
(A)
Giulia Gori
(G)
Giacomo Grandi
(G)
Paolo Grimaldi
(P)
Alice Lampugnani
(A)
Francesco Lapia
(F)
Federica Lepore
(F)
Gianluca Lettieri
(G)
Jacopo Mambella
(J)
Chiara Mercanti
(C)
Stefania Merli
(S)
Francesco Mordà
(F)
Alba Nardone
(A)
Luca Pace
(L)
Lucia Padovini
(L)
Alessandro Parodi
(A)
Ivan Pellegrino
(I)
Lavinia Pitotti
(L)
Margherita Reduzzi
(M)
Giovanni Rigano
(G)
Giovanni Romito
(G)
Giorgio Rotola
(G)
Umberto Sabatini
(U)
Lucia Salvi
(L)
Giovanni Santacroce
(G)
Jessica Savioli
(J)
Simone Soriano
(S)
Carmine Spataro
(C)
Debora Stefani
(D)
Anna Rita Aliberti
(AR)
Alessandro Amatu
(A)
Laura Anfossi
(L)
Eric Arisi
(E)
Chiara Baldi
(C)
Mirko Belliato
(M)
Lorenzo Bellini
(L)
Alberto Benzi
(A)
Germana Bichisao
(G)
Antonia Bolongaro
(A)
Andrea Bottazzi
(A)
Federica Broglia
(F)
Giacomo Bruschi
(G)
Luca Caneva
(L)
Emanuele Capaccio
(E)
Valeria Carboni
(V)
Fabrizio Cavalloro
(F)
Maria Ciceri
(M)
Luca Civardi
(L)
Maria Paola Delmonte
(MP)
Elisa Lucia Domenegati
(EL)
Federica Ferrari
(F)
Fiorenza Ferrari
(F)
Marta Ferrari
(M)
Marinella Fuardo
(M)
Maddalena Margherita Gerletti
(MM)
Simonetta Gualdana
(S)
Marcella Ilardi
(M)
Claudia Lo Coco
(C)
Giuseppe Maggio
(G)
Maria Benedetta Mascia
(MB)
Simonetta Mencherini
(S)
Paola Maria Merati
(PM)
Silvia Mongodi
(S)
Anna Maria Mori
(AM)
Federica Morgante
(F)
Thekla Larissa Niebel
(TL)
Silvano Noli
(S)
Anita Orlando
(A)
Michele Pagani
(M)
Debora Passador
(D)
Simona Pellicori
(S)
Luciano Perotti
(L)
Raffaella Picchioni
(R)
Silvia Poma
(S)
Marco Pozzi
(M)
Emanuela Preti
(E)
Roberta Puce
(R)
Danila Katia Radolovich
(DK)
Gianluca Ragni
(G)
Filippo Repossi
(F)
Francesca Riccardi
(F)
Roberto Rizzardi
(R)
Giuseppe Rodi
(G)
Emanuela Roldi
(E)
Giovanni Romito
(G)
Cristina Rossi
(C)
Giuseppe Sala Gallini
(G)
Fabio Sciutti
(F)
Debora Sportiello
(D)
Giulia Ticozzelli
(G)
Federico Visconti
(F)
Silvia Zizzi
(S)
Alessandro Bagliani
(A)
Corrado Belotti
(C)
Chiara Bossi
(C)
Andrea Colombo
(A)
Costanza Natalia Julia Colombo
(CNJ)
Luca Cremascoli
(L)
Valentino Dammassa
(V)
Roberto Discepoli
(R)
Maria Adelaide Garlando
(MA)
Filippo Grandini
(F)
Andrea Pellegrini
(A)
Cecilia Quaranta
(C)
Andrea Stella
(A)
Francesco Torresani
(F)
Mario Mondelli
(M)
Enrico Brunetti
(E)
Angela Di Matteo
(A)
Elena Seminari
(E)
Laura Maiocchi
(L)
Valentina Zuccaro
(V)
Layla Pagnucco
(L)
Bianca Mariani
(B)
Serena Ludovisi
(S)
Raffaella Lissandrin
(R)
Aldo Parisi
(A)
Paolo Sacchi
(P)
Savino F A Patruno
(SFA)
Giuseppe Michelone
(G)
Roberto Gulminetti
(R)
Domenico Zanaboni
(D)
Stefano Novati
(S)
Renato Maserati
(R)
Paolo Orsolini
(P)
Marco Vecchia
(M)
Erika Asperges
(E)
Alessandro Di Filippo
(A)
Margherita Sambo
(M)
Simona Biscarini
(S)
Matteo Lupi
(M)
Silvia Roda
(S)
Ilaria Gallazzi
(I)
Michele Sachs
(M)
Pietro Valsecchi
(P)
Alessandra Ferrari
(A)
Bianca Mariani
(B)
Matteo Bosio
(M)
Alessandro Cascina
(A)
Valentina Conio
(V)
Rita Di Domenica
(R)
Anna Donnetta
(A)
Elia Fraolini
(E)
Giuseppe Gualtieri
(G)
Patrizia Mangiarotti
(P)
Francesca Mariani
(F)
Federica Meloni
(F)
Tiberio Oggionni
(T)
Lidia Pasturenzi
(L)
Vanessa Ronzoni
(V)
Laura Saracino
(L)
Giulia Stella
(G)
Stefano Tomaselli
(S)
Tommaso Abbate
(T)
Giulia Accordino
(G)
Francesco Bertuccio
(F)
Cecilia Burattini
(C)
Elisa Cacciatore
(E)
Elena Cattaneo
(E)
Vittorio Chino
(V)
Manuela Coretti
(M)
Matteo Della Zoppa
(M)
Cristina Infusino
(C)
Sara Lettieri
(S)
Valeria Maccabruni
(V)
Silvia Mancinelli
(S)
Claudio Tirelli
(C)
Valentina Vertui
(V)
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020. The Author(s).
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