The Circadian Clock and Viral Infections.
COVID-19
circadian rhythm
virology
virus-clock
viruses
Journal
Journal of biological rhythms
ISSN: 1552-4531
Titre abrégé: J Biol Rhythms
Pays: United States
ID NLM: 8700115
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
10
11
2020
medline:
23
3
2021
entrez:
9
11
2020
Statut:
ppublish
Résumé
The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks in peripheral tissues, thereby regulating our immune system and the severity of infections. These rhythms affect the pharmacokinetics and efficacy of therapeutic agents and vaccines. The core circadian regulatory circuits and clock-regulated host pathways provide fertile ground to identify novel antiviral therapies. An increased understanding of the role circadian systems play in regulating virus infection and the host response to the virus will inform our clinical management of these diseases. This review provides an overview of the experimental and clinical evidence reporting on the interplay between the circadian clock and viral infections, highlighting the importance of virus-clock research.
Identifiants
pubmed: 33161818
doi: 10.1177/0748730420967768
pmc: PMC7924106
doi:
Substances chimiques
CLOCK Proteins
EC 2.3.1.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-22Subventions
Organisme : Medical Research Council
ID : G0400802
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0801976
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R022011/1
Pays : United Kingdom
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