Early Pathological JC Virus Lesions in a Patient without Any MRI-based Indications.
CSF PCR
JC virus
progressive multifocal leukoencephalopathy
viral infection
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Apr 2021
15 Apr 2021
Historique:
pubmed:
10
11
2020
medline:
17
4
2021
entrez:
9
11
2020
Statut:
ppublish
Résumé
A 70-year-old woman with a human T-cell leukemia virus type 1 infection without any focal neurological symptoms showed age-related atherosclerotic changes in the white matter without any suspicious signal changes suggestive of progressive multifocal leukoencephalopathy (PML) based on the findings of MRI. Viral polymerase chain reaction (PCR) revealed 6,700 copies/mL of the JC virus genome in the cerebrospinal fluid (CSF). An immuno-pathological examination of the autopsied brain revealed JC virus capsid proteins, and in situ hybridization confirmed a JC virus infection, indicating that an active infection begins at the radiologically indistinguishable phase of PML. An early JC virus infection is probably associated with small, scattered demyelinating lesions around the cortico-medullary area of the cortex.
Identifiants
pubmed: 33162483
doi: 10.2169/internalmedicine.6040-20
pmc: PMC8112995
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1279-1282Références
Case Rep Neurol Med. 2015;2015:643216
pubmed: 25861493
Intern Med. 2016;55(12):1631-5
pubmed: 27301518
Rev Med Virol. 2016 Mar;26(2):102-14
pubmed: 26663440
J Virol. 2004 Sep;78(18):9890-903
pubmed: 15331723
Ann Clin Transl Neurol. 2014 Oct;1(10):755-64
pubmed: 25493267
Neurology. 2013 Apr 9;80(15):1430-8
pubmed: 23568998
Radiology. 2016 Mar;278(3):863-72
pubmed: 26436861
Jpn J Infect Dis. 2011;64(3):211-6
pubmed: 21617305
Acta Neuropathol. 2010 Sep;120(3):403-17
pubmed: 20464404
Mult Scler Int. 2015;2015:809252
pubmed: 26483978