Red blood cell exchange in sickle cell disease patient with multiple alloantibodies.
Alloimmunization
red blood cell exchange
sickle cell disease
sickle hemoglobin
Journal
Asian journal of transfusion science
ISSN: 0973-6247
Titre abrégé: Asian J Transfus Sci
Pays: India
ID NLM: 101306858
Informations de publication
Date de publication:
Historique:
received:
24
03
2018
accepted:
12
08
2018
entrez:
9
11
2020
pubmed:
10
11
2020
medline:
10
11
2020
Statut:
ppublish
Résumé
There are several reports in medical literature about Red Cell Exchange (RCE) being routinely performed pre-operatively in sickle cell disease patients to provide immediate decrease in HbS concentration and prevent post-operative complications. We would like to present one such case of SCD who also had multiple allo-antibodies and had to undergo hemi-arthroplasty for avascular necrosis of head femur. Grouping and antibody screening was performed using column agglutination technique. 3-cell and 11- cell panel were used for antibody screening and identification, respectively. Automated RBC exchange was performed on apheresis machine Com. Tec using the standard PL1 kit (Fresenius Kabi, Germany). Multiple (anti-c, E) allo-antibodies were identified and successful pre-operative RCE was done with corresponding antigen-negative AHG compatible RBC units. Single RCE procedure reduced HbS concentration from 65% to 25%. The patient underwent uneventful hemi-arthroplasty and was discharged on post-operative day-7. Patient is on regular follow-up and continues to do well two months after the day of surgery. This is possibly the first case report from India, which illustrates successful automated RCE in a SCD patient with alloimmunization.
Identifiants
pubmed: 33162712
doi: 10.4103/ajts.AJTS_36_18
pii: AJTS-14-70
pmc: PMC7607993
doi:
Types de publication
Case Reports
Langues
eng
Pagination
70-73Informations de copyright
Copyright: © 2020 Asian Journal of Transfusion Science.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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