Tolerogenic Immunomodulation by PEGylated Antigenic Peptides.
autoimmunity
immune tolerance
nanoparticles
peptide vaccination
regulatory T cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
01
2020
accepted:
22
09
2020
entrez:
9
11
2020
pubmed:
10
11
2020
medline:
30
4
2021
Statut:
epublish
Résumé
Current treatments for autoimmune disorders rely on non-specific immunomodulatory and global immunosuppressive drugs, which show a variable degree of efficiency and are often accompanied by side effects. In contrast, strategies aiming at inducing antigen-specific tolerance promise an exclusive specificity of the immunomodulation. However, although successful in experimental models, peptide-based tolerogenic "inverse" vaccines have largely failed to show efficacy in clinical trials. Recent studies showed that repetitive T cell epitopes, coupling of peptides to autologous cells, or peptides coupled to nanoparticles can improve the tolerogenic efficacy of peptides, suggesting that size and biophysical properties of antigen constructs affect the induction of tolerance. As these materials bear hurdles with respect to preparation or regulatory aspects, we wondered whether conjugation of peptides to the well-established and clinically proven synthetic material polyethylene glycol (PEG) might also work. We here coupled the T cell epitope OVA
Identifiants
pubmed: 33162973
doi: 10.3389/fimmu.2020.529035
pmc: PMC7581722
doi:
Substances chimiques
Epitopes, T-Lymphocyte
0
Peptides
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
529035Informations de copyright
Copyright © 2020 Pfeil, Simonetti, Lauer, Volkmer, von Thülen, Durek, Krähmer, Leenders, Hamann and Hoffmann.
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