Peroxisome Deficiency Impairs BDNF Signaling and Memory.
BDNF
Pex2
TrkB
conditional knockout
memory disturbance
neural stem cell
peroxisome
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
05
2020
accepted:
22
09
2020
entrez:
9
11
2020
pubmed:
10
11
2020
medline:
10
11
2020
Statut:
epublish
Résumé
Peroxisome is an intracellular organelle that functions in essential metabolic pathways including β-oxidation of very-long-chain fatty acids and biosynthesis of plasmalogens. Peroxisome biogenesis disorders (PBDs) manifest severe dysfunction in multiple organs including central nervous system (CNS), whilst the pathogenic mechanisms are largely unknown. We recently reported that peroxisome-deficient neural cells secrete an increased level of brain-derived neurotrophic factor (BDNF), resulting in the cerebellar malformation. Peroxisomal functions in adulthood brain have been little investigated. To induce the peroxisome deficiency in adulthood brain, we here established tamoxifen-inducible conditional
Identifiants
pubmed: 33163488
doi: 10.3389/fcell.2020.567017
pmc: PMC7591468
doi:
Types de publication
Journal Article
Langues
eng
Pagination
567017Informations de copyright
Copyright © 2020 Abe, Nishimura, Nakamura, Tamura, Honsho, Udo, Yamashita and Fujiki.
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