The effect of geniposide on chronic unpredictable mild stress-induced depressive mice through BTK/TLR4/NF-κB and BDNF/TrkB signaling pathways.
BDNF/TrkB pathway
BTK/TLR4/NF-κB pathway
CUMS
Geniposide
PC12 cells
depression
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
10
05
2019
revised:
15
07
2020
accepted:
18
07
2020
pubmed:
10
11
2020
medline:
31
3
2021
entrez:
9
11
2020
Statut:
ppublish
Résumé
The purpose of this study was to estimate the pharmacological effect of geniposide (GEN) on depression, caused by chronic unpredictable mild stress (CUMS), and explore its potential mechanism. During the 6 week CUMS procedure, the mice were treated with GEN (10, 40 mg/kg) by gavage once daily for 3 weeks. As a result, the GEN treatment remarkably improved the behavioral manifestations and suppressed the generations of inflammatory cytokines both in vivo and in vitro. The MDA level was significantly increased, while the activities of SOD, GSH-PX were decreased in CUMS-challenged mice and corticosterone-stimulated PC12 cells. GEN administration significantly inhibited those changes. Moreover, GEN treatment could downregulate the expressions of p-BTK, TLR4, MyD88, p-NF-κB proteins, and upregulate BDNF, p-TrkB generations in CUMS-induced mice. Moreover, GEN administration inhibited the protein levels of p-BTK, TLR4, MyD88, p-NF-κB in corticosterone-induced PC12 cell. In summary, the results suggested that GEN exerted a therapeutic effect on CUMS-induced depressive mice possibly through the regulation of BTK/TLR4/NF-κB and BDNF/TrkB signaling pathways.
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Iridoids
0
NF-kappa B
0
Toll-Like Receptor 4
0
geniposide
145295QLXY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
932-945Subventions
Organisme : Fundamental Research Funds for the Central Universities
ID : 2632017PY14
Organisme : National Natural Science Foundation
ID : 81673434
Organisme : "Double First-Class" University project
ID : CPU2018GY22
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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