Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery.
Journal
Chemical reviews
ISSN: 1520-6890
Titre abrégé: Chem Rev
Pays: United States
ID NLM: 2985134R
Informations de publication
Date de publication:
24 03 2021
24 03 2021
Historique:
pubmed:
10
11
2020
medline:
28
9
2021
entrez:
9
11
2020
Statut:
ppublish
Résumé
The crisis of antibiotic resistance necessitates creative and innovative approaches, from chemical identification and analysis to the assessment of bioactivity. Plant natural products (NPs) represent a promising source of antibacterial lead compounds that could help fill the drug discovery pipeline in response to the growing antibiotic resistance crisis. The major strength of plant NPs lies in their rich and unique chemodiversity, their worldwide distribution and ease of access, their various antibacterial modes of action, and the proven clinical effectiveness of plant extracts from which they are isolated. While many studies have tried to summarize NPs with antibacterial activities, a comprehensive review with rigorous selection criteria has never been performed. In this work, the literature from 2012 to 2019 was systematically reviewed to highlight plant-derived compounds with antibacterial activity by focusing on their growth inhibitory activity. A total of 459 compounds are included in this Review, of which 50.8% are phenolic derivatives, 26.6% are terpenoids, 5.7% are alkaloids, and 17% are classified as other metabolites. A selection of 183 compounds is further discussed regarding their antibacterial activity, biosynthesis, structure-activity relationship, mechanism of action, and potential as antibiotics. Emerging trends in the field of antibacterial drug discovery from plants are also discussed. This Review brings to the forefront key findings on the antibacterial potential of plant NPs for consideration in future antibiotic discovery and development efforts.
Identifiants
pubmed: 33164487
doi: 10.1021/acs.chemrev.0c00922
pmc: PMC8183567
mid: NIHMS1709145
doi:
Substances chimiques
Alkaloids
0
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Biological Products
0
Phenols
0
Plant Extracts
0
Terpenes
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3495-3560Subventions
Organisme : NIAID NIH HHS
ID : R21 AI136563
Pays : United States
Organisme : NCCIH NIH HHS
ID : R21 AT011105
Pays : United States
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