Genetic variation in
Adult
CARD Signaling Adaptor Proteins
/ genetics
Case-Control Studies
Diabetes Mellitus, Type 2
/ complications
Diabetic Nephropathies
/ diagnosis
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Inflammasomes
/ immunology
Male
Middle Aged
NLR Family, Pyrin Domain-Containing 3 Protein
/ immunology
Neoplasm Proteins
/ genetics
Phenotype
Pilot Projects
Polymorphism, Single Nucleotide
Risk Assessment
Risk Factors
CAspase Recruitment Domain family member 8 gene
NLRP3 inflammasome
diabetic nephropathy
genetic association
type 2 diabetes mellitus
Journal
Diabetes & vascular disease research
ISSN: 1752-8984
Titre abrégé: Diab Vasc Dis Res
Pays: England
ID NLM: 101234011
Informations de publication
Date de publication:
Historique:
entrez:
9
11
2020
pubmed:
10
11
2020
medline:
26
1
2021
Statut:
ppublish
Résumé
Approximately one third of type 2 diabetes mellitus (T2DM) cases present with diabetic nephropathy (DN), the leading cause of end-stage renal disease. Inflammation plays an important role in T2DM disease and DN pathogenesis. NLRP3 inflammasomes are complexes that regulate interleukin-1B (IL-1B) and IL-18 secretion, both involved in inflammatory responses. Activation of NLRP3 is associated with DN onset and progression. Here, we explore whether DN is associated with variants in genes encoding key members of the NLRP3 inflammasome pathway. Using genome-wide association data, we performed a pilot case-control association study, between 101 DN-T2DM and 185 non-DN-T2DM cases from the Hellenic population across six NLRP3 inflammasome pathway genes. Three common CARD8 acts as an NLRP3, NF-κB and caspase-1 inhibitor; perhaps, alterations in the cross-talk between CARD8, NF-κB, and NLRP3, which could affect the pro-inflammatory environment in T2DM, render diabetic carriers of certain common
Sections du résumé
BACKGROUND
Approximately one third of type 2 diabetes mellitus (T2DM) cases present with diabetic nephropathy (DN), the leading cause of end-stage renal disease. Inflammation plays an important role in T2DM disease and DN pathogenesis. NLRP3 inflammasomes are complexes that regulate interleukin-1B (IL-1B) and IL-18 secretion, both involved in inflammatory responses. Activation of NLRP3 is associated with DN onset and progression. Here, we explore whether DN is associated with variants in genes encoding key members of the NLRP3 inflammasome pathway.
METHODS
Using genome-wide association data, we performed a pilot case-control association study, between 101 DN-T2DM and 185 non-DN-T2DM cases from the Hellenic population across six NLRP3 inflammasome pathway genes.
RESULTS
Three common
CONCLUSION
CARD8 acts as an NLRP3, NF-κB and caspase-1 inhibitor; perhaps, alterations in the cross-talk between CARD8, NF-κB, and NLRP3, which could affect the pro-inflammatory environment in T2DM, render diabetic carriers of certain common
Identifiants
pubmed: 33164551
doi: 10.1177/1479164120970892
pmc: PMC7919199
doi:
Substances chimiques
CARD Signaling Adaptor Proteins
0
CARD8 protein, human
0
Inflammasomes
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
NLRP3 protein, human
0
Neoplasm Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1479164120970892Références
Metabolism. 2017 Sep;74:1-9
pubmed: 28764843
Int Urol Nephrol. 2018 Feb;50(2):321-329
pubmed: 29196930
Diab Vasc Dis Res. 2018 Jul;15(4):340-343
pubmed: 29392977
J Mol Neurosci. 2021 Feb;71(2):276-283
pubmed: 32613553
Hypertension. 2012 Jul;60(1):154-62
pubmed: 22647887
J Biol Chem. 2002 Apr 19;277(16):13952-8
pubmed: 11821383
Arthritis Res Ther. 2014 Feb 12;16(1):R52
pubmed: 24517500
J Clin Invest. 2018 May 1;128(5):1793-1806
pubmed: 29408806
Nat Rev Immunol. 2011 Feb;11(2):98-107
pubmed: 21233852
Kidney Int. 2015 Jan;87(1):74-84
pubmed: 25075770
Int J Mol Med. 2012 Sep;30(3):697-702
pubmed: 22711073
J Biol Chem. 2001 Nov 23;276(47):44069-77
pubmed: 11551959
Clin Exp Nephrol. 2015 Feb;19(1):1-5
pubmed: 25527479
J Diabetes Res. 2015;2015:616747
pubmed: 26273672
Nat Rev Nephrol. 2019 Aug;15(8):501-520
pubmed: 31164720