Social behavior in mice following chronic optogenetic stimulation of hippocampal engrams.
Behavior
Engrams
Hippocampus
Learning
Memory
Optogenetics
Journal
Neurobiology of learning and memory
ISSN: 1095-9564
Titre abrégé: Neurobiol Learn Mem
Pays: United States
ID NLM: 9508166
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
28
05
2020
revised:
19
09
2020
accepted:
27
09
2020
pubmed:
10
11
2020
medline:
28
9
2021
entrez:
9
11
2020
Statut:
ppublish
Résumé
The hippocampus processes both spatial-temporal information and emotionally salient experiences. To test the functional properties of discrete sets of cells in the dorsal dentate gyrus (dDG), we examined whether chronic optogenetic reactivation of these ensembles was sufficient to modulate social behaviors in mice. We found that chronic reactivation of discrete dDG cell populations in male mice largely did not affect social behaviors in an experience-dependent manner. However, we found that social behavior in a female exposure task was increased following chronic optogenetic stimulation when compared to pre-stimulation levels, suggesting that the protocol led to increased social behavior, although alternative explanations are discussed. Furthermore, multi-region analysis of neural activity did not yield detectable differences in immediate-early gene expression or neurogenesis following chronic optogenetic stimulation. Together, these results suggest that the effects of chronic optogenetic stimulation in the dDG on social behaviors are independent of the contextual experience processed by each cellular ensemble.
Identifiants
pubmed: 33164892
pii: S1074-7427(20)30165-9
doi: 10.1016/j.nlm.2020.107321
pmc: PMC7708439
mid: NIHMS1644844
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107321Subventions
Organisme : NIH HHS
ID : DP5 OD023106
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD101402
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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