COVID-19 Hospitalization in Adults with Type 1 Diabetes: Results from the T1D Exchange Multicenter Surveillance Study.


Journal

The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362

Informations de publication

Date de publication:
23 01 2021
Historique:
received: 09 09 2020
pubmed: 10 11 2020
medline: 28 1 2021
entrez: 9 11 2020
Statut: ppublish

Résumé

Diabetes mellitus is associated with increased COVID-19 morbidity and mortality, but there are few data focusing on outcomes in people with type 1 diabetes. The objective of this study was to analyze characteristics of adults with type 1 diabetes for associations with COVID-19 hospitalization. An observational multisite cross-sectional study was performed. Diabetes care providers answered a 33-item questionnaire regarding demographics, symptoms, and diabetes- and COVID-19-related care and outcomes. Descriptive statistics were used to describe the study population, and multivariate logistic regression models were used to analyze the relationship between glycated hemoglobin (HbA1c), age, and comorbidities and hospitalization. Cases were submitted from 52 US sites between March and August 2020. Adults over the age of 19 with type 1 diabetes and confirmed COVID-19 infection were included. None. Hospitalization for COVID-19 infection. A total of 113 cases were analyzed. Fifty-eight patients were hospitalized, and 5 patients died. Patients who were hospitalized were more likely to be older, to identify as non-Hispanic Black, to use public insurance, or to have hypertension, and less likely to use continuous glucose monitoring or insulin pumps. Median HbA1c was 8.6% (70 mmol/mol) and was positively associated with hospitalization (odds ratio 1.42, 95% confidence interval 1.18-1.76), which persisted after adjustment for age, sex, race, and obesity. Baseline glycemic control and access to care are important modifiable risk factors which need to be addressed to optimize care of people with type 1 diabetes during the worldwide COVID-19 pandemic.

Identifiants

pubmed: 33165563
pii: 5963916
doi: 10.1210/clinem/dgaa825
pmc: PMC7717244
doi:

Types de publication

Journal Article Multicenter Study Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

e936-e942

Subventions

Organisme : NIDDK NIH HHS
ID : K23 DK115896
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK111022
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK112751
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK097820
Pays : United States

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Auteurs

Grenye O'Malley (G)

Department of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine, New York, New York.

Osagie Ebekozien (O)

T1D Exchange, Boston, Massachusetts.

Marisa Desimone (M)

Division of Endocrinology, Diabetes and Metabolism, SUNY Upstate Medical University, Syracuse, New York.

Catherina T Pinnaro (CT)

Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa.

Alissa Roberts (A)

Department of Pediatrics, University of Washington, Seattle, Washington.

Sarit Polsky (S)

Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Nudrat Noor (N)

T1D Exchange, Boston, Massachusetts.

Grazia Aleppo (G)

Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Marina Basina (M)

Stanford University School of Medicine, Stanford, California.

Michael Tansey (M)

Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa.

Devin Steenkamp (D)

Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.

Francesco Vendrame (F)

Division of Endocrinology, Diabetes, and Metabolism, University of Miami, Miami, Florida.

Ilona Lorincz (I)

Department of Endocrinology, Diabetes, and Metabolism, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania.

Priyanka Mathias (P)

Fleischer Institute for Diabetes and Metabolism, NY-Regional Center for Diabetes and Translational Research, Albert Einstein College of Medicine, New York, New York.

Shivani Agarwal (S)

Fleischer Institute for Diabetes and Metabolism, NY-Regional Center for Diabetes and Translational Research, Albert Einstein College of Medicine, New York, New York.

Lauren Golden (L)

NYU Langone Medical Center, New York, New York.

Irl B Hirsch (IB)

University of Washington School of Medicine, Seattle, Washington.

Carol J Levy (CJ)

Department of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine, New York, New York.

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