Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles.
adherens junctions
afadin
cancer progression
metastasis
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
13
08
2020
revised:
17
09
2020
accepted:
24
09
2020
pubmed:
10
11
2020
medline:
19
8
2021
entrez:
9
11
2020
Statut:
ppublish
Résumé
Adherens (AJ) and tight junctions (TJ) maintain cell-cell adhesions and cellular polarity in normal tissues. Afadin, a multi-domain scaffold protein, is commonly found in both adherens and tight junctions, where it plays both structural and signal-modulating roles. Afadin is a complex modulator of cellular processes implicated in cancer progression, including signal transduction, migration, invasion, and apoptosis. In keeping with the complexities associated with the roles of adherens and tight junctions in cancer, afadin exhibits both tumor suppressive and pro-metastatic functions. In this review, we will explore the dichotomous roles that afadin plays during cancer progression.
Identifiants
pubmed: 33165933
doi: 10.1002/bies.202000221
doi:
Substances chimiques
Microfilament Proteins
0
afadin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000221Subventions
Organisme : CIHR
ID : MOP-136907
Pays : Canada
Informations de copyright
© 2020 Wiley Periodicals LLC.
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