Development of a Red-Light-Controllable Nitric Oxide Releaser to Control Smooth Muscle Relaxation

Animals Aorta / drug effects HEK293 Cells Humans Light Male Muscle Relaxation / drug effects Muscle, Smooth, Vascular / drug effects Nitric Oxide Donors / chemistry Rats Rats, Wistar Rhodamines / chemistry Vasodilation / drug effects

Journal

ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906

Informations de publication

Date de publication:
20 11 2020
Historique:
pubmed: 10 11 2020
medline: 28 5 2021
entrez: 9 11 2020
Statut: ppublish

Résumé

We designed and synthesized a novel Si-rhodamine derivative, NORD-1, as a red-light-controllable nitric oxide (NO) releaser, on the basis of photoredox parameter analysis. Red-light-responsive NO release from NORD-1 was confirmed by ESR spin trapping and quantified with an NO electrode and by means of Griess assay. The NO release cross section (ε

Identifiants

DOI: 10.1021/acschembio.0c00601 PMID: 33166443
pubmed: 33166443
doi: 10.1021/acschembio.0c00601
doi:

Substances chimiques

Nitric Oxide Donors 0
Rhodamines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2958-2965

Auteurs

Naoya Ieda (N)

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

Yuji Hotta (Y)

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

Ayaka Yamauchi (A)

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

Atsushi Nishikawa (A)

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

Takahiro Sasamori (T)

Graduate School of Natural Sciences, Nagoya City University, 1 Yamanohata, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8501, Japan.
ORCID: 0000-0001-5410-8488

Daisuke Saitoh (D)

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

Mitsuyasu Kawaguchi (M)

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.
ORCID: 0000-0002-1919-1391

Kazunori Kimura (K)

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

Hidehiko Nakagawa (H)

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.
ORCID: 0000-0001-8435-4401

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Development of a Red-Light-Controllable Nitric...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Aorte › Development of a Red-Light-Controllable Nitric...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Development of a Red-Light-Controllable Nitric...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Development of a Red-Light-Controllable Nitric...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Development of a Red-Light-Controllable Nitric...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Relâchement musculaire › Development of a Red-Light-Controllable Nitric...
questionsmedicales.fr › Tissus › Muscles › Muscles lisses › Muscles lisses vasculaires › Development of a Red-Light-Controllable Nitric...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Donneur d'oxyde nitrique › Development of a Red-Light-Controllable Nitric...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Development of a Red-Light-Controllable Nitric...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Development of a Red-Light-Controllable Nitric...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Xanthènes › Rhodamines › Development of a Red-Light-Controllable Nitric...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Development of a Red-Light-Controllable Nitric...