Association of Optic Nerve Head Prelaminar Schisis With Glaucoma.
Adult
Aged
Aged, 80 and over
Cross-Sectional Studies
Female
Follow-Up Studies
Glaucoma
/ complications
Humans
Intraocular Pressure
/ physiology
Male
Middle Aged
Nerve Fibers
/ pathology
Optic Disk
/ pathology
Optic Nerve Diseases
/ diagnosis
Prospective Studies
Retinal Ganglion Cells
/ pathology
Tomography, Optical Coherence
/ methods
Young Adult
Journal
American journal of ophthalmology
ISSN: 1879-1891
Titre abrégé: Am J Ophthalmol
Pays: United States
ID NLM: 0370500
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
12
05
2020
revised:
24
10
2020
accepted:
27
10
2020
pubmed:
10
11
2020
medline:
27
4
2021
entrez:
9
11
2020
Statut:
ppublish
Résumé
To compare the frequency of observing optic nerve head (ONH) prelaminar schisis by optical coherence tomography (OCT) in glaucoma and glaucoma suspect (GL/S) eyes vs healthy control (HC) eyes and to assess its association with other markers of glaucoma severity. This cross-sectional study included 298 eyes of 150 GL/S patients and 88 eyes of 44 HCs. OCT scans were obtained, including 24 radial B-scans, each composed of 768 A-lines spanning 15°, centered on the ONH. Two reviewers masked to all other clinical, demographic, and ocular information independently graded the OCT scans for the presence of ONH prelaminar schisis on a 4-point scale of 0 (none) to 3 (severe). The probability of ONH schisis was compared between groups and against demographic and ocular factors, including structural and functional measures of glaucoma severity. The frequency and severity of ONH prelaminar schisis were greater in GL/S than in HC (P = .009). Among the GL/S group, 165 eyes (55.4%) had no visible schisis (Grade 0), 71 (23.8%) had Grade 1, 46 (15.4%) had Grade 2 and 16 (5.4%) had Grade 3 schisis. Among HC eyes, 59 (67.0%) had Grade 0, 24 (27.3%) had Grade 1, 5 (5.7%) had Grade 2, none had Grade 3. ONH schisis was more common in eyes with thinner MRW and a deeper cup. ONH prelaminar schisis may be a sign of glaucomatous deformation and reflect ongoing pathophysiological damage. ONH prelaminar schisis can impact OCT image segmentation and diagnostic parameters, resulting in substantial overestimation of the true rim tissue thickness and underestimation of cup depth.
Identifiants
pubmed: 33166501
pii: S0002-9394(20)30603-6
doi: 10.1016/j.ajo.2020.10.021
pmc: PMC7979447
mid: NIHMS1644567
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
246-258Subventions
Organisme : NEI NIH HHS
ID : R01 EY020922
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY021281
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY030590
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
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