Bryophyllum pinnatum markers: CPC isolation, simultaneous quantification by a validated UPLC-DAD method and biological evaluations.

Brazil Flavonoids Kalanchoe Plant Extracts / pharmacology Plant Leaves
Bryophyllum pinnatum Centrifugal partition chromatography Flavonoid Herbal medicine Marker Method validation

Journal

Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336

Informations de publication

Date de publication:
30 Jan 2021
Historique:
received: 02 05 2020
revised: 03 10 2020
accepted: 05 10 2020
pubmed: 10 11 2020
medline: 22 6 2021
entrez: 9 11 2020
Statut: ppublish

Résumé

Bryophyllum pinnatum (Lam.) Oken (Crassulaceae) is widely used as leaf juice or extracts in traditional medicine all over tropical areas, especially in Brazil, to relieve inflammation-associated symptoms. Flavonol glycosides with unusual sugar moiety are among the major metabolites. Nevertheless, there are not enough quality control studies that can contribute to authentication of B. pinnatum and determination of their markers. As it is also used as medicinal plant in several countries, it is necessary to provide data related to safety, efficacy and quality. In this context, this work aims to isolate the major flavonoids from B. pinnatum hydroethanolic extract, to validate a method to quantify the content of chemical markers and to evaluate their xanthine oxidase inhibition and antioxidant activity. The extract was submitted to centrifugal partition chromatography (CPC). The solvents system CyHex-EtOAc-EtOH-H

Identifiants

DOI: 10.1016/j.jpba.2020.113682 PMID: 33166841
pubmed: 33166841
pii: S0731-7085(20)31568-5
doi: 10.1016/j.jpba.2020.113682
pii:
doi:

Substances chimiques

Flavonoids 0
Plant Extracts 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113682

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors report no declarations of interest.

Auteurs

Júlia Morais Fernandes (J)

Grupo de Pesquisa em Produtos Naturais Bioativos, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, 59.012-570 Natal, Brazil.

Sergio Ortiz (S)

Equipe Produits Naturels, Analyse, Synthèse, UMR CNRS 8038, Faculté de Pharmacie, Equipe Produits Naturels, Analyse, Synthèse, UMR CNRS 8038, Faculté de Pharmacie, Université de Paris, 75006, Paris, France.

Raquel Padilha M Tavares (R)

Grupo de Pesquisa em Produtos Naturais Bioativos, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, 59.012-570 Natal, Brazil.

Tsvetelina Mandova (T)

Equipe Produits Naturels, Analyse, Synthèse, UMR CNRS 8038, Faculté de Pharmacie, Equipe Produits Naturels, Analyse, Synthèse, UMR CNRS 8038, Faculté de Pharmacie, Université de Paris, 75006, Paris, France; Gilson Purification SAS, Saint-Avé, France.

Edilane Rodrigues D Araújo (E)

Grupo de Pesquisa em Produtos Naturais Bioativos, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, 59.012-570 Natal, Brazil.

Anderson Wilbur L Andrade (AW)

Grupo de Pesquisa em Produtos Naturais Bioativos, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, 59.012-570 Natal, Brazil.

Sylvie Michel (S)

Equipe Produits Naturels, Analyse, Synthèse, UMR CNRS 8038, Faculté de Pharmacie, Equipe Produits Naturels, Analyse, Synthèse, UMR CNRS 8038, Faculté de Pharmacie, Université de Paris, 75006, Paris, France.

Raphaël Grougnet (R)

Equipe Produits Naturels, Analyse, Synthèse, UMR CNRS 8038, Faculté de Pharmacie, Equipe Produits Naturels, Analyse, Synthèse, UMR CNRS 8038, Faculté de Pharmacie, Université de Paris, 75006, Paris, France. Electronic address: raphael.grougnet@parisdescartes.fr.

Silvana Maria Zucolotto (SM)

Grupo de Pesquisa em Produtos Naturais Bioativos, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, 59.012-570 Natal, Brazil. Electronic address: silvanazucolotto@ufrnet.br.

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Classifications MeSH

questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Sud › Brésil › Bryophyllum pinnatum markers: CPC isolation,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Bryophyllum pinnatum markers: CPC isolation,...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rosanae › Rosales › Crassulaceae › Kalanchoe › Bryophyllum pinnatum markers: CPC isolation,...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Bryophyllum pinnatum markers: CPC isolation,...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Feuilles de plante › Bryophyllum pinnatum markers: CPC isolation,...