Targeting B cells for inflammatory bowel disease treatment: back to the future.
Journal
Current opinion in pharmacology
ISSN: 1471-4973
Titre abrégé: Curr Opin Pharmacol
Pays: England
ID NLM: 100966133
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
08
06
2020
revised:
30
09
2020
accepted:
05
10
2020
pubmed:
10
11
2020
medline:
14
10
2021
entrez:
9
11
2020
Statut:
ppublish
Résumé
B cells are critical to immune homeostasis at mucosal surfaces including those of the gastrointestinal tract. B cell-related abnormalities, comprising of a lympho-plasmacytic infiltrate, as well as anti-microbial antibodies, are well reported in patients with inflammatory bowel disease (IBD). However, B cell-targeting is not part of the therapeutic armamentarium in IBD. Recently, driven by the identification of genetic associations between IgG Fc receptors and IBD susceptibility, there has been renewed interest in defining the immunobiology of B cells during mucosal inflammation. Functional studies have demonstrated mechanisms of IgG-mediated disease pathogenesis and deep mucosal immunophenotyping using single cell RNA sequencing has elaborated a significant remodelling of the B cell compartment in IBD. In light of these novel data, here we discuss potential strategies to target B cell immunity in IBD. Finally, we discuss potential risks and pitfalls of these approaches and emphasize on distinguishing between homeostatic and pathological B cell signatures, allowing for a data-based, prudent therapeutic approach.
Identifiants
pubmed: 33166872
pii: S1471-4892(20)30100-4
doi: 10.1016/j.coph.2020.10.002
pmc: PMC7894973
mid: NIHMS1668326
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
90-98Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK112296
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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