Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population.
8-hydroxy-2′-deoxyguanosine
diabetic polyneuropathy
elevated pain threshold
inflammation
normal-high HbA1c
oxidative stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Nov 2020
05 Nov 2020
Historique:
received:
12
10
2020
revised:
02
11
2020
accepted:
03
11
2020
entrez:
10
11
2020
pubmed:
11
11
2020
medline:
17
3
2021
Statut:
epublish
Résumé
Normal-high HbA1c levels are a risk factor for attenuated pain sensation in normoglycemic subjects. It is unclear, however, what mechanisms underlie the pathogenesis of attenuated pain sensation in such a population. We, therefore, explored the relationship between oxidative stress (OS) and pain sensation in a rural Japanese population. A population-based study of 894 individuals (average age 53.8 ± 0.5 years) and 55 subjects with impaired fasting glucose (IFG) were enrolled in this study. Individuals with diabetes were excluded. Relationships between pain threshold induced by intraepidermal electrical stimulation (PINT) and clinico-hematological parameters associated with OS were evaluated. Univariate linear regression analyses revealed age, BMI, HbA1c, the OS biomarker urine 8-hydroxy-2'-deoxyguanosine (8-OHdG), systolic blood pressure, and decreased Achilles tendon reflex on the PINT scores. Adjustments for age, gender, and multiple clinical measures confirmed a positive correlation between PINT scores and urine 8-OHdG (β = 0.09,
Identifiants
pubmed: 33167536
pii: ijms21218306
doi: 10.3390/ijms21218306
pmc: PMC7663937
pii:
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Glycated Hemoglobin A
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Scand J Clin Lab Invest. 2016 Dec;76(8):620-625
pubmed: 27666677
Diabetes Care. 2004 Sep;27(9):2178-83
pubmed: 15333481
Invest Ophthalmol Vis Sci. 2000 Sep;41(10):2915-21
pubmed: 10967045
Neurology. 2003 Jan 14;60(1):108-11
pubmed: 12525727
Antioxidants (Basel). 2020 Jul 07;9(7):
pubmed: 32645985
J Diabetes Investig. 2010 Apr 22;1(1-2):40-9
pubmed: 24843407
Front Endocrinol (Lausanne). 2019 Oct 02;10:651
pubmed: 31632344
Metabolism. 2019 Feb;91:53-60
pubmed: 30513280
Diabetes Metab Res Rev. 2014 Nov;30(8):669-78
pubmed: 24687457
Muscle Nerve. 2016 Jun;54(1):146-9
pubmed: 27104656
J Neurochem. 2008 Jan;104(2):491-9
pubmed: 17995925
Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):3-14
pubmed: 18199707
J Diabetes Investig. 2011 Jan 24;2(1):18-32
pubmed: 24843457
BMJ Open Diabetes Res Care. 2020 Oct;8(1):
pubmed: 33099510
Eur J Clin Invest. 2011 Apr;41(4):442-50
pubmed: 21128935
Nature. 2000 Nov 9;408(6809):239-47
pubmed: 11089981
J Neurol Sci. 2004 Dec 15;227(1):119-30
pubmed: 15546602
Med Princ Pract. 2011;20(2):187-90
pubmed: 21252578
Continuum (Minneap Minn). 2014 Oct;20(5 Peripheral Nervous System Disorders):1226-40
pubmed: 25299279
Int J Biochem Cell Biol. 2007;39(1):44-84
pubmed: 16978905
N Engl J Med. 2005 Jan 27;352(4):341-50
pubmed: 15673800
J Atheroscler Thromb. 2006 Feb;13(1):68-75
pubmed: 16505594
Muscle Nerve. 2016 May;53(5):671-82
pubmed: 26872938
Diabetologia. 1999 Aug;42(8):995-8
pubmed: 10491760
Free Radic Res. 2012 Oct;46(10):1291-5
pubmed: 22789030
J Diabetes Investig. 2010 Oct 19;1(5):212-28
pubmed: 24843435
Pain. 2002 Apr;96(3):247-52
pubmed: 11972996
Pharmacol Ther. 2008 Oct;120(1):1-34
pubmed: 18616962
Proc Natl Acad Sci U S A. 1988 Sep;85(17):6465-7
pubmed: 3413108
FEBS Lett. 1997 Nov 3;417(1):150-2
pubmed: 9395094
Diabet Med. 2016 Jan;33(1):62-9
pubmed: 25970541
J Trace Elem Med Biol. 2010 Oct;24(4):236-42
pubmed: 20832272
Eur J Pharmacol. 2006 Mar 8;533(1-3):240-52
pubmed: 16464450
Neurosci Lett. 2014 Jun 6;570:69-74
pubmed: 24731795
Science. 1996 Jul 5;273(5271):59-63
pubmed: 8658196
J Assoc Physicians India. 2019 Sep;67(9):60-64
pubmed: 31561691
Diabetes Care. 2003 May;26(5):1507-12
pubmed: 12716813
Neuron. 2017 Mar 22;93(6):1296-1313
pubmed: 28334605