Hair cortisol-a method to detect chronic cortisol levels in patients with Prader-Willi syndrome.
Chronic stress
Hair cortisol
Obesity
Prader-Willi syndrome
Journal
BMC endocrine disorders
ISSN: 1472-6823
Titre abrégé: BMC Endocr Disord
Pays: England
ID NLM: 101088676
Informations de publication
Date de publication:
10 Nov 2020
10 Nov 2020
Historique:
received:
28
05
2020
accepted:
26
10
2020
entrez:
10
11
2020
pubmed:
11
11
2020
medline:
18
8
2021
Statut:
epublish
Résumé
Prader-Willi syndrome (PWS) is a multisymptomatic, rare, genetic, neurodevelopmental disorder in adults mainly characterized by hyperphagia, cognitive dysfunction, behavioral problems and risk of morbid obesity. Although endocrine insufficiencies are common, hypocortisolism is rare and knowledge on long-term cortisol concentrations is lacking. The aim of this study was to evaluate long-term cortisol levels in PWS by measurements of hair cortisol. Twenty-nine adults with PWS, 15 men and 14 women, median age 29 years, median BMI 27 kg/m In the PWS group large variations in hair cortisol was seen. Mean hair cortisol was 12.8 ± 25.4 pg/mg compared to 3.8 ± 7.3 pg/mg in controls (p = 0.001). The linear regression model similarly showed higher cortisol levels in patients with PWS, which remained consistent after adjusting for BMI and stress (p = 0.023). Furthermore, hair cortisol increased with BMI (p = 0.012) and reported stress (p = 0.014). Long-term cortisol concentrations were higher in patients with PWS compared to controls and increased with BMI and stress, suggesting an adequate cortisol response to chronic stress. Hair cortisol demonstrate promising applications in the context of PWS treatment and disease management.
Sections du résumé
BACKGROUND
BACKGROUND
Prader-Willi syndrome (PWS) is a multisymptomatic, rare, genetic, neurodevelopmental disorder in adults mainly characterized by hyperphagia, cognitive dysfunction, behavioral problems and risk of morbid obesity. Although endocrine insufficiencies are common, hypocortisolism is rare and knowledge on long-term cortisol concentrations is lacking. The aim of this study was to evaluate long-term cortisol levels in PWS by measurements of hair cortisol.
METHODS
METHODS
Twenty-nine adults with PWS, 15 men and 14 women, median age 29 years, median BMI 27 kg/m
RESULTS
RESULTS
In the PWS group large variations in hair cortisol was seen. Mean hair cortisol was 12.8 ± 25.4 pg/mg compared to 3.8 ± 7.3 pg/mg in controls (p = 0.001). The linear regression model similarly showed higher cortisol levels in patients with PWS, which remained consistent after adjusting for BMI and stress (p = 0.023). Furthermore, hair cortisol increased with BMI (p = 0.012) and reported stress (p = 0.014).
CONCLUSION
CONCLUSIONS
Long-term cortisol concentrations were higher in patients with PWS compared to controls and increased with BMI and stress, suggesting an adequate cortisol response to chronic stress. Hair cortisol demonstrate promising applications in the context of PWS treatment and disease management.
Identifiants
pubmed: 33167936
doi: 10.1186/s12902-020-00646-w
pii: 10.1186/s12902-020-00646-w
pmc: PMC7654170
doi:
Substances chimiques
Biomarkers
0
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
166Subventions
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek
ID : 91716453
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