The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study.
autism spectrum disorders
cognition
psychosocial functioning
schizophrenia
social cognition
Journal
European psychiatry : the journal of the Association of European Psychiatrists
ISSN: 1778-3585
Titre abrégé: Eur Psychiatry
Pays: England
ID NLM: 9111820
Informations de publication
Date de publication:
10 11 2020
10 11 2020
Historique:
pubmed:
11
11
2020
medline:
1
5
2021
entrez:
10
11
2020
Statut:
epublish
Résumé
Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals. To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia. The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures. Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p < 0.001), and participation in community-living activities (p < 0.001). These findings strengthen the notion that ASD symptoms may have a relevant impact on different aspects of the disease, crucial to the life of people with schizophrenia. Prominent ASD symptoms may characterize a specific subpopulation of individuals with SSD.
Sections du résumé
BACKGROUND
Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals.
AIMS
To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia.
METHODS
The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures.
RESULTS
Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p < 0.001), and participation in community-living activities (p < 0.001).
CONCLUSIONS
These findings strengthen the notion that ASD symptoms may have a relevant impact on different aspects of the disease, crucial to the life of people with schizophrenia. Prominent ASD symptoms may characterize a specific subpopulation of individuals with SSD.
Identifiants
pubmed: 33168115
doi: 10.1192/j.eurpsy.2020.99
pii: S0924933820000991
pmc: PMC7737172
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e98Investigateurs
Anna Ceraso
(A)
Alessandro Galluzzo
(A)
Jacopo Lisoni
(J)
Piergiuseppe Di Palo
(P)
Marco Papalino
(M)
Raffaella Romano
(R)
Federica Pinna
(F)
Alice Lai
(A)
Silvia Lostia di Santa Sofia
(SL)
Paola Bucci
(P)
Giuseppe Piegari
(G)
Francesco Brando
(F)
Luigi Giuliani
(L)
Maria Salvina Signorelli
(MS)
Laura Fusar Poli
(L)
Giovanni Martinotti
(G)
Mauro Pettorruso
(M)
Chiara Montemitro
(C)
Mario Altamura
(M)
Stefania Malerba
(S)
Flavia Padalino
(F)
Andrea Amerio
(A)
Pietro Calcagno
(P)
Domenico Zampogna
(D)
Laura Giusti
(L)
Anna Salza
(A)
Silvia Mammarella
(S)
Francesca Pacitti
(F)
Valentina Socci
(V)
Dalila Talevi
(D)
Carla Gramaglia
(C)
Alessandro Feggi
(A)
Amalia Jona
(A)
Angela Favaro
(A)
Elena Tenconi
(E)
Paolo Meneguzzo
(P)
Paolo Ossola
(P)
Matteo Tonna
(M)
Maria Lidia Gerra
(ML)
Claudia Carmassi
(C)
Camilla Gesi
(C)
Barbara Carpita
(B)
Giulio Corrivetti
(G)
Giammarco Cascino
(G)
Gianfranco Del Buono
(G)
Fabio Di Fabio
(F)
Antonio Buzzanca
(A)
Nicoletta Girardi
(N)
Roberto Brugnoli
(R)
Anna Comparelli
(A)
Valentina Corigliano
(V)
Andrea Fagiolini
(A)
Simone Bolognesi
(S)
Arianna Goracci
(A)
Giorgio Di Lorenzo
(G)
Cinzia Niolu
(C)
Michele Ribolsi
(M)
Claudio Brasso
(C)
Cecilia Riccardi
(C)
Elisa Del Favero
(E)
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