Ceramide analog [
Alzheimer Disease
/ diagnostic imaging
Amides
Animals
Apolipoprotein E3
/ genetics
Apolipoprotein E4
/ genetics
Astrocytes
/ metabolism
Brain
/ diagnostic imaging
Ceramides
/ chemistry
Disease Models, Animal
Female
Fluorine Radioisotopes
Hippocampus
/ metabolism
Lipidomics
Mass Spectrometry
Mice
Mice, Knockout, ApoE
ROC Curve
Sensitivity and Specificity
Sphingolipids
/ chemistry
Sphingomyelins
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 11 2020
09 11 2020
Historique:
received:
18
06
2020
accepted:
22
10
2020
entrez:
10
11
2020
pubmed:
11
11
2020
medline:
1
5
2021
Statut:
epublish
Résumé
The metabolism of ceramides is deregulated in the brain of Alzheimer's disease (AD) patients and is associated with apolipoprotein (APO) APOE4 and amyloid-β pathology. However, how the ceramide metabolism changes over time in AD, in vivo, remains unknown. Distribution and metabolism of [
Identifiants
pubmed: 33168861
doi: 10.1038/s41598-020-76335-4
pii: 10.1038/s41598-020-76335-4
pmc: PMC7652882
doi:
Substances chimiques
Amides
0
Apolipoprotein E3
0
Apolipoprotein E4
0
Ceramides
0
Fluorine Radioisotopes
0
N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide
0
Sphingolipids
0
Sphingomyelins
0
Fluorine-18
GZ5I74KB8G
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
19354Subventions
Organisme : VA
ID : VA I01BX003643
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG064234
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG064234
Pays : United States
Organisme : NIH HHS
ID : R01AG034389
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095215
Pays : United States
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