Exploring new horizons in health care: A mechanistic review on the potential of Unani medicines in combating epidemics of infectious diseases.
Unani
epidemic
immunomodulatory
infection
pandemic
wabā
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
03
09
2020
received:
16
07
2020
accepted:
30
10
2020
medline:
11
11
2020
pubmed:
11
11
2020
entrez:
10
11
2020
Statut:
ppublish
Résumé
The 20th and 21st centuries have witnessed epidemics and pandemics of various infectious agents. The development of effective antimicrobials in the 20th century has been complemented with the emergence of resistant and mutant strains. In this context, we present a comprehensive overview of the preventive measures described in Unani medicine during epidemics. Unani medicine is a traditional medicine system included in the Indian Systems of Medicine. Unani medicine has an extensive description of epidemic infections and preventive and therapeutic measures for the same. Certain factors like environment, season, and geographical location of a place are known to determine the extent of infections, and their escalation to epidemics. Maintenance of general health, immune-stimulation, and disinfecting of the environment are advised as protective measures, for which many drugs are prescribed. In the case of illness, specific antimicrobial drugs of natural origin are prescribed. Herein we discuss these measures in detail, along with the scientific evidences of anti-microbial, immunomodulatory, and health-protective actions of these drugs.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2317-2335Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
Abdallah, E. M., Qureshi, K. A., Ali, A. M. H., & Elhassan, G. O. (2017). Evaluation of some biological properties of Saussurea costus crude root extract. Bioscience Biotechnology Research Communications, 10(4), 601-611. https://doi.org/10.21786/bbrc/10.4/2
Abu-Reidah, I. M., Ali-Shtayeh, M. S., Jamous, R. M., Arráez-Román, D., & Segura-Carretero, A. (2015). HPLC-DAD-ESI-MS/MS screening of bioactive components from Rhus coriaria L. (sumac) fruits. Food Chemistry, 166, 179-191. https://doi.org/10.1016/j.foodchem.2014.06.011
Acquaviva, R., D'Angeli, F., Malfa, G. A., Ronsisvalle, S., Garozzo, A., Stivala, A., … Genovese, C. (2019). Antibacterial and anti-biofilm activities of walnut pellicle extract (Juglans regia L.) against coagulase-negative staphylococci. Natural Product Research, 33, 1-6. https://doi.org/10.1080/14786419.2019.1650352
Aldred, E. (2009). Terpenes. In E. M. Aldred, C. Buck, & K. B. T.-P. Vall (Eds.), Pharmacology (pp. 167-174). London, England: Churchill Livingstone. https://doi.org/10.1016/b978-0-443-06898-0.00022-0
Al-Fuhaid, N. A. (2017). Larvicidal and growth regulatory of gum resin powders from Aloe Vera, Astragalus Sarcocolla, Commefora Myrrha and Ferula assa-foetida L against Trogoderma granarium Everts. International Journal of Agricultural Science and Research, 7(4), 597-604. https://doi.org/10.24247/ijasraug201777
Amin, A., Tuenter, E., Cos, P., Maes, L., Exarchou, V., Apers, S., & Pieters, L. (2016). Antiprotozoal and antiglycation activities of sesquiterpene coumarins from Ferula narthex exudate. Molecules, 21(10), 1287. https://doi.org/10.3390/molecules21101287
Aprotosoaie, A. C., Luca, V. S., Trifan, A., & Miron, A. (2018). Antigenotoxic potential of some dietary non-phenolic phytochemicals. In B. T.-S. In N. P. C. Atta-ur-Rahman (Ed.), Studies in natural products chemistry (Vol. 60, pp. 223-297). United Kingdom: Elsevier. https://doi.org/10.1016/B978-0-444-64181-6.00007-3
Armijos, C., Valarezo, E., Cartuche, L., Zaragoza, T., Finzi, P. V., Mellerio, G. G., & Vidari, G. (2018). Chemical composition and antimicrobial activity of Myrcianthes fragrans essential oil, a natural aromatizer of the traditional Ecuadorian beverage colada morada. Journal of Ethnopharmacology, 225, 319-326. https://doi.org/10.1016/j.jep.2018.07.018
Azzi, A. (2018). Many tocopherols, one vitamin E. Molecular Aspects of Medicine, 61, 92-103. https://doi.org/10.1016/j.mam.2017.06.004
Bachrouch, O., Jemâa, J., Ben, M., Talou, T., Marzouk, B., & Abderraba, M. (2010). Fumigant toxicity of Pistacia lentiscus essential oil against Tribolium castaneum and Lasioderma serricorne. Bulletin of Insectology, 63(1), 129-135.
Baghdadi, I. H. (2004). Kitab al-Mukhtarat fil-Tib, New Delhi: Central Council for Research in Unani Medicine.
Bartnik, M., & Facey, P. C. (2017). Glycosides. In S. Badal & R. B. T.-P. Delgoda (Eds.), Pharmacognosy: Fundamentals, applications and strategy (pp. 101-161). New York, NY: Academic Press. https://doi.org/10.1016/B978-0-12-802104-0.00008-1
Bhalodia, N., Acharya, R., Nariya, P., & Shukla, V. (2012). In vitro antibacterial and antifungal activities of Cassia fistula Linn. fruit pulp extracts. AYU (an International Quarterly Journal of Research in Ayurveda), 33(1), 123-129. https://doi.org/10.4103/0974-8520.100329
Bhatwalkar, S. B., Shukla, P., Srivastava, R. K., Mondal, R., & Anupam, R. (2019). Validation of environmental disinfection efficiency of traditional Ayurvedic fumigation practices. Journal of Ayurveda and Integrative Medicine, 10(3), 203-206. https://doi.org/10.1016/j.jaim.2019.05.002
Bone, K., & Mills, S. B. T.-P. (Eds.) (2013). Principles of herbal pharmacology. In Principles and practice of phytotherapy (2nd ed., pp. 17-82). USA: Churchill Livingstone. https://doi.org/10.1016/b978-0-443-06992-5.00002-5
Borrego, S., Valdés, O., Vivar, I., Lavin, P., Guiamet, P., Battistoni, P., … Borges, P. (2012). Essential oils of plants as biocides against microorganisms isolated from Cuban and argentine documentary heritage. ISRN Microbiology, 2012, 1-7. https://doi.org/10.5402/2012/826786
Boulaaba, M., Snoussi, M., Saada, M., Mkadmini, K., Smaoui, A., Abdelly, C., & Ksouri, R. (2015). Antimicrobial activities and phytochemical analysis of Tamarix gallica extracts. Industrial Crops and Products, 76, 1114-1122. https://doi.org/10.1016/j.indcrop.2015.08.020
Boyce, J. M. (2018). Alcohols as surface disinfectants in healthcare settings. Infection Control and Hospital Epidemiology, 39(3), 323-328. https://doi.org/10.1017/ice.2017.301
Cabrera-Perez, J., Badovinac, V. P., & Griffith, T. S. (2017). Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease. Experimental Biology and Medicine, 242(2), 127-139. https://doi.org/10.1177/1535370216669610
Caparrotta, S., Comparini, D., Marone, E., Kimmenfield, R., Luzzietti, L., Taiti, C., & Mancuso, S. (2019). Correlation between VOC fingerprinting and antimicrobial activity of several essential oils extracted by plant resins against a. tumefaciens and P. savastanoi. Flavour and Fragrance Journal, 34(5), 377-387. https://doi.org/10.1002/ffj.3518
Chairatana, P., & Nolan, E. M. (2017). Defensins, lectins, mucins, and secretory immunoglobulin a: Microbe-binding biomolecules that contribute to mucosal immunity in the human gut. Critical Reviews in Biochemistry and Molecular Biology, 52(1), 45-56. https://doi.org/10.1080/10409238.2016.1243654
Chaubey, M. K. (2013). Biological activities of Zingiber officinale (Zingiberaceae) and Piper cubeba (Piperaceae) essential oils against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae). Pakistan Journal of Biological Sciences, 16(11), 517-523. https://doi.org/10.3923/pjbs.2013.517.523
Chen, G. L., Zheng, F. J., Sun, J., Li, Z. C., Lin, B., & Li, Y. R. (2015). Production and characteristics of high quality vinegar from sugarcane juice. Sugar Tech, 17(1), 89-93. https://doi.org/10.1007/s12355-014-0352-z
Chen, H., Chen, T., Giudici, P., & Chen, F. (2016). Vinegar functions on health: Constituents, sources, and formation mechanisms. Comprehensive Reviews in Food Science and Food Safety, 15(6), 1124-1138. https://doi.org/10.1111/1541-4337.12228
Chen, H., Pu, J., Liu, D., Yu, W., Shao, Y., Yang, G., … He, N. (2016). Anti-inflammatory and antinociceptive properties of flavonoids from the fruits of black mulberry (Morus nigra L). PLoS One, 11(4), e0153080. https://doi.org/10.1371/journal.pone.0153080
Chen, W., Vermaak, I., & Viljoen, A. (2013). Camphor-a fumigant during the black death and a coveted fragrant wood in ancient Egypt and babylon-a review. Molecules, 18(5), 5434-5454. https://doi.org/10.3390/molecules18055434
Chien, S. C., Wu, Y. C., Chen, Z. W., & Yang, W. C. (2015). Naturally occurring anthraquinones: Chemistry and therapeutic potential in autoimmune diabetes. Evidence-based Complementary and Alternative Medicine, 2015, 1-13. https://doi.org/10.1155/2015/357357
Cisowska, A., Wojnicz, D., & Hendrich, A. B. (2011). Anthocyanins as antimicrobial agents of natural plant origin. Natural Product Communications, 6(1), 149-156. https://doi.org/10.1177/1934578x1100600136
Čivljak, R., Markotić, A., & Kuzman, I. (2020). The third coronavirus epidemic in the third millennium: What's next? Croatian Medical Journal, 61(1), 1-4. https://doi.org/10.3325/cmj.2020.61.1
Cortesia, C., Vilchèze, C., Bernut, A., Contreras, W., Gómez, K., de Waard, J., … Takiff, H. (2014). Acetic acid, the active component of vinegar, is an effective tuberculocidal disinfectant. MBio, 5(2), e00013-e00014. https://doi.org/10.1128/mBio.00013-14
Cubaiu, L., Ladu, G., Pintore, G. L., d'Hallewin, G., Venditti, T., & Petretto, G. L. (2015). Rosmarinus officinalis L. and Myrtus communis L. essential oils treatments by vapor contact to control Penicillium digitatum. Journal of Food Processing & Technology, 06(09), 1-7. https://doi.org/10.4172/2157-7110.1000492
da Silva Oliveira, F. G., de Souza Araújo, C., Rolim, L. A., Barbosa-Filho, J. M., & da Silva Almeida, J. R. G. (2018). The genus Hymenaea (Fabaceae): A chemical and pharmacological review. In N. P. C. Atta-ur-Rahman (Ed.), Studies in natural products chemistry (Vol. 58, pp. 339-388). United Kingdom: Elsevier. https://doi.org/10.1016/B978-0-444-64056-7.00012-X
Da Silveira, E., Sá, R. D. C., Andrade, L. N., De Oliveira, R. D. R. B., & De Sousa, D. P. (2014). A review on anti-inflammatory activity of phenylpropanoids found in essential oils. Molecules, 19(2), 1459-1480. https://doi.org/10.3390/molecules19021459
Dasaklis, T. K., Pappis, C. P., & Rachaniotis, N. P. (2012). Epidemics control and logistics operations: A review. International Journal of Production Economics, 139(2), 393-410. https://doi.org/10.1016/j.ijpe.2012.05.023
De Pádua Lúcio, K., Rabelo, A. C. S., Araújo, C. M., Brandão, G. C., De Souza, G. H. B., Da Silva, R. G., … Costa, D. C. (2018). Anti-inflammatory and antioxidant properties of black mulberry (Morus nigra L.) in a model of LPS-induced sepsis. Oxidative Medicine and Cellular Longevity, 2018, 1-13. https://doi.org/10.1155/2018/5048031
Deka Bhuyan, P., Chutia, M., Pathak, M. G., & Baruah, P. (2010). Effect of essential oils from lippia geminata and Cymbopogon jwarancusa on in vitro growth and sporulation of two rice pathogens. JAOCS, Journal of the American Oil Chemists' Society, 87(11), 1333-1340. https://doi.org/10.1007/s11746-010-1620-z
Du, J., Singh, H., & Yi, T. H. (2016). Antibacterial, anti-biofilm and anticancer potentials of green synthesized silver nanoparticles using benzoin gum (Styrax benzoin) extract. Bioprocess and Biosystems Engineering, 39(12), 1923-1931. https://doi.org/10.1007/s00449-016-1666-x
Espina, L., Gelaw, T. K., de Lamo-Castellví, S., Pagán, R., & García-Gonzalo, D. (2013). Mechanism of bacterial inactivation by (+)-limonene and its potential use in food preservation combined processes. PLoS One, 8(2), e56769. https://doi.org/10.1371/journal.pone.0056769
Fazil, M., & Nikhat, S. (2020). Topical medicines for wound healing: A systematic review of Unani literature with recent advances. Journal of Ethnopharmacology, 257, 112878. https://doi.org/10.1016/j.jep.2020.112878
Feyzabadi, Z., Ghorbani, F., Vazani, Y., & Zarshenas, M. M. (2017). A critical review on Phytochemistry, pharmacology of Viola odorata L. and related multipotential products in traditional Persian medicine. Phytotherapy Research, 31(11), 1669-1675. https://doi.org/10.1002/ptr.5909
Fidan, H., Stefanova, G., Kostova, I., Stankov, S., Damyanova, S., Stoyanova, A., & Zheljazkov, V. D. (2019). Chemical composition and antimicrobial activity of Laurus nobilis L. essential oils from Bulgaria. Molecules, 24(4), 804. https://doi.org/10.3390/molecules24040804
Fineberg, H. V. (2014). Global health: Pandemic preparedness and response - lessons from the H1N1 influenza of 2009. New England Journal of Medicine, 370(14), 1335-1342. https://doi.org/10.1056/NEJMra1208802
Gabr, S. A., & Alghadir, A. H. (2019). Evaluation of the biological effects of lyophilized hydrophilic extract of Rhus coriaria on myeloperoxidase (MPO) activity, wound healing, and microbial infections of skin wound tissues. Evidence-based Complementary and Alternative Medicine, 2019, 1-14. https://doi.org/10.1155/2019/5861537
Ganesan, K., & Xu, B. (2017). Polyphenol-rich lentils and their health promoting effects. International Journal of Molecular Sciences, 18(11), 2390. https://doi.org/10.3390/ijms18112390
Gao, Q. H., Wu, C. S., & Wang, M. (2013). The jujube (Ziziphus jujuba mill.) fruit: A review of current knowledge of fruit composition and health benefits. Journal of Agricultural and Food Chemistry, 61(14), 3351-3363. https://doi.org/10.1021/jf4007032
Getts, D. R., Spiteri, A., King, N. J. C., & Miller, S. D. (2019). Microbial infection as a trigger of t-cell autoimmunity. In N. R. Rose & I. R. Mackay (Eds.), The Autoimmune Diseases (6th ed., pp. 363-374). United Kingdom: Academic Press. https://doi.org/10.1016/B978-0-12-812102-3.00021-X
Gohari, A. R., Saeidnia, S., & Mahmoodabadi, M. K. (2013). An overview on saffron, phytochemicals, and medicinal properties. Pharmacognosy Reviews, 7(13), 61-66. https://doi.org/10.4103/0973-7847.112850
González-Molina, E., Domínguez-Perles, R., Moreno, D. A., & García-Viguera, C. (2010). Natural bioactive compounds of Citrus limon for food and health. Journal of Pharmaceutical and Biomedical Analysis, 51(2), 327-345. https://doi.org/10.1016/j.jpba.2009.07.027
Guimarães, A. C., Meireles, L. M., Lemos, M. F., Guimarães, M. C. C., Endringer, D. C., Fronza, M., & Scherer, R. (2019). Antibacterial activity of terpenes and terpenoids present in essential oils. Molecules, 24(13), 2471. https://doi.org/10.3390/molecules24132471
Guo, G., Ye, L., Pan, K., Chen, Y., Xing, D., Yan, K., … Xue, X. (2020). New insights of emerging SARS-CoV-2: Epidemiology, etiology, clinical features, clinical treatment, and prevention. Frontiers in Cell and Developmental Biology, 8, 410. https://doi.org/10.3389/fcell.2020.00410
Guo, Q., Du, G., Qi, H., Zhang, Y., Yue, T., Wang, J., & Li, R. (2017). A nematicidal tannin from Punica granatum L. rind and its physiological effect on pine wood nematode (Bursaphelenchus xylophilus). Pesticide Biochemistry and Physiology, 135, 64-68. https://doi.org/10.1016/j.pestbp.2016.06.003
Gwari, G., Bhandari, U., Andola, H. C., Lohani, H., & Chauhan, N. (2013). Volatile constituents of Saussurea costus roots cultivated in Uttarakhand Himalayas, India. Pharmacognosy Research, 5(3), 179-182. https://doi.org/10.4103/0974-8490.112424
Hacini, Z., Khedja, F., Habib, I., Kendour, Z., & Debba, Z. (2018). Evaluation of antibacterial and antioxidant activities of three types of benzoin resin. European Journal of Chemistry, 9(4), 408-411. https://doi.org/10.5155/eurjchem.9.4.408-411.1755
Holešová, S., Hundáková, M., & Pazdziora, E. (2016). Antibacterial kaolinite based Nanocomposites. Procedia Materials Science, 12, 124-129. https://doi.org/10.1016/j.mspro.2016.03.022
Honigsbaum, M. (2020). Revisiting the 1957 and 1968 influenza pandemics. The Lancet, 395(10240), 1824-1826. https://doi.org/10.1016/S0140-6736(20)31201-0
Igwe, E. O., & Charlton, K. E. (2016). A systematic review on the health effects of plums (Prunus domestica and Prunus salicina). Phytotherapy Research, 30(5), 701-731. https://doi.org/10.1002/ptr.5581
Isik, S., Tayman, C., Cakir, U., Koyuncu, I., Taskin Turkmenoglu, T., & Cakir, E. (2019). Sumac (Rhus coriaria) for the prevention and treatment of necrotizing enterocolitis. Journal of Food Biochemistry, 43(12), e13068. https://doi.org/10.1111/jfbc.13068
Jean, S. S., Lee, P. I., & Hsueh, P. R. (2020). Treatment options for COVID-19: The reality and challenges. Journal of Microbiology, Immunology, and Infection, 53, 436-443. https://doi.org/10.1016/j.jmii.2020.03.034
Jones, D. S. (2020). History in a crisis-lessons for Covid-19. The New England Journal of Medicine, 382(18), 1-3.
Joseph, S. V., Edirisinghe, I., & Burton-Freeman, B. M. (2016). Fruit polyphenols: A review of anti-inflammatory effects in humans. Critical Reviews in Food Science and Nutrition, 56(3), 419-444. https://doi.org/10.1080/10408398.2013.767221
Jung, H. L., Yang, S. Y., Pyo, M. C., Hong, C. O., Nam, M. H., Lee, J. W., & Lee, K. W. (2019). Protective effects of chebulic acid from Terminalia chebula Retz. Against t-BHP-induced oxidative stress by modulations of Nrf2 and its related enzymes in HepG2 cells. Food Science and Biotechnology, 28(2), 555-562. https://doi.org/10.1007/s10068-018-0477-z
Kamaruzaman, N. A., Sulaiman, S. A., Kaur, G., & Yahaya, B. (2014). Inhalation of honey reduces airway inflammation and histopathological changes in a rabbit model of ovalbumin-induced chronic asthma. BMC Complementary and Alternative Medicine, 14, 176. https://doi.org/10.1186/1472-6882-14-176
Kazemi, M. (2015). Chemical composition and antimicrobial activity of essential oil of Matricaria recutita. International Journal of Food Properties, 18(8), 1784-1792. https://doi.org/10.1080/10942912.2014.939660
Khan, A. (2011). Al-Ikseer, New Delhi: Idara Kitab al-Shifa.
Kim, J., Jang, M., Shin, E., Kim, J., Lee, S. H., & Park, C. G. (2016). Fumigant and contact toxicity of 22 wooden essential oils and their major components against Drosophila suzukii (Diptera: Drosophilidae). Pesticide Biochemistry and Physiology, 133, 35-43. https://doi.org/10.1016/j.pestbp.2016.03.007
Komakech, R., Kim, Y., Matsabisa, G. M., & Kang, Y. (2019). Anti-inflammatory and analgesic potential of Tamarindus indica Linn. (Fabaceae): A narrative review. Integrative Medicine Research, 8(3), 181-186. https://doi.org/10.1016/j.imr.2019.07.002
Korkina, L., Kostyuk, V., De Luca, C., & Pastore, S. (2011). Plant Phenylpropanoids as emerging anti-inflammatory agents. Mini-Reviews in Medicinal Chemistry, 11(10), 823-835. https://doi.org/10.2174/138955711796575489
Kosanić, M., & Ranković, B. (2019). Lichen secondary metabolites as potential antibiotic agents. In Lichen secondary metabolites (2nd ed.) Switzerland: Springer. https://doi.org/10.1007/978-3-030-16814-8_3
Kuchta, K., Tung, N. H., Ohta, T., Uto, T., Raekiansyah, M., Grötzinger, K., … Morita, K. (2020). The old pharmaceutical oleoresin labdanum of Cistus creticus L. exerts pronounced in vitro anti-dengue virus activity. Journal of Ethnopharmacology, 257, 112316. https://doi.org/10.1016/j.jep.2019.112316
Lee, J. E., Jung, M., Lee, S. C., Huh, M. J., Seo, S. M., & Park, I. K. (2020). Antibacterial mode of action of trans-cinnamaldehyde derived from cinnamon bark (Cinnamomum verum) essential oil against agrobacterium tumefaciens. Pesticide Biochemistry and Physiology, 165, 104546. https://doi.org/10.1016/j.pestbp.2020.02.012
Lim, A., Subhan, N., Jazayeri, J. A., John, G., Vanniasinkam, T., & Obied, H. K. (2016). Plant phenols as antibiotic boosters: in vitro interaction of olive leaf phenols with ampicillin. Phytotherapy Research, 30(3), 503-509. https://doi.org/10.1002/ptr.5562
Lim, T. K. (2012). In T. K. Lim (Ed.), Edible medicinal and non-medicinal plants: Volume 2, Fruits (Vol. 2, pp. 1-1088). Switzerland: Springer. https://doi.org/10.1007/978-94-007-1764-0
Lima, M. C., Paiva de Sousa, C., Fernandez-Prada, C., Harel, J., Dubreuil, J. D., & de Souza, E. L. (2019). A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria. Microbial Pathogenesis, 130(February), 259-270. https://doi.org/10.1016/j.micpath.2019.03.025
Lima, Z. M., Da Trindade, L. S., Santana, G. C., Padilha, F. F., Da Costa Mendonça, M., Da Costa, L. P., … Macedo, M. L. H. (2017). Effect of Tamarindus indica L. and Manihot esculenta extracts on antibiotic-resistant bacteria. Pharmacognosy Research, 9(2), 195-199. https://doi.org/10.4103/0974-8490.204648
Liu, Z. L., He, Q., Chu, S. S., Wang, C. F., Du, S. S., & Deng, Z. W. (2012). Essential oil composition and larvicidal activity of Saussurea lappa roots against the mosquito Aedes albopictus (Diptera: Culicidae). Parasitology Research, 110(6), 2125-2130. https://doi.org/10.1007/s00436-011-2738-0
Ludwiczuk, A., Skalicka-Woźniak, K., & Georgiev, M. I. (2017). Terpenoids. In S. Badal & R. Delgoda (Eds.), Pharmacognosy: Fundamentals, applications and strategy (pp. 233-266). United Kingdom: Academic Press. https://doi.org/10.1016/B978-0-12-802104-0.00011-1
Ma, L. L., Ge, M., Wang, H. Q., Yin, J. Q., Jiang, J. D., & Li, Y. H. (2015). Antiviral activities of several Oral traditional Chinese medicines against influenza viruses. Evidence-based Complementary and Alternative Medicine, 2015, 1-9. https://doi.org/10.1155/2015/367250
Madsen, C. K., & Brinch-Pedersen, H. (2016). The Antinutritional components of grains. In Reference module in food science, Amsterdam: Elsevier. https://doi.org/10.1016/b978-0-08-100596-5.00111-6
Mahboubi, M. (2016). Rosa damascena as holy ancient herb with novel applications. Journal of Traditional and Complementary Medicine, 6(1), 10-16. https://doi.org/10.1016/j.jtcme.2015.09.005
Mahizan, N. A., Yang, S. K., Moo, C. L., Song, A. A. L., Chong, C. M., Chong, C. W., … Lai, K. S. (2019). Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens. Molecules, 24(14), 2631. https://doi.org/10.3390/molecules24142631
Mamelund, S. E. (2018). 1918 pandemic morbidity: The first wave hits the poor, the second wave hits the rich. Influenza and Other Respiratory Viruses, 12(3), 307-313. https://doi.org/10.1111/irv.12541
Mani-López, E., García, H. S., & López-Malo, A. (2012). Organic acids as antimicrobials to control salmonella in meat and poultry products. Food Research International, 45(2), 713-721. https://doi.org/10.1016/j.foodres.2011.04.043
Matthäus, B., Özcan, M. M., Al Juhaimi, F., Adiamo, O. Q., Alsawmahi, O. N., Ghafoor, K., & Babike, E. E. (2018). Effect of the harvest time on oil yield, fatty acid, tocopherol and sterol contents of developing almond and walnut kernels. Journal of Oleo Science, 67(1), 39-45. https://doi.org/10.5650/jos.ess17162
Maurya, A. K., Devi, R., Kumar, A., Koundal, R., Thakur, S., Sharma, A., … Agnihotri, V. K. (2018). Chemical composition, cytotoxic and antibacterial activities of essential oils of cultivated clones of Juniperus communis and wild Juniperus species. Chemistry and Biodiversity, 15(9), e1800183. https://doi.org/10.1002/cbdv.201800183
Mericli, F., Becer, E., Kabadayi, H., Hanoglu, A., Hanoglu, D. Y., Yavuz, D. O., … Vatansever, S. (2017). Fatty acid composition and anticancer activity in colon carcinoma cell lines of Prunus dulcis seed oil. Pharmaceutical Biology, 55(1), 1239-1248. https://doi.org/10.1080/13880209.2017.1296003
Miras-Moreno, B., Sabater-Jara, A. B., Pedreno, M. A., & Almagro, L. (2016). Bioactivity of Phytosterols and their production in plant in vitro cultures. Journal of Agricultural and Food Chemistry, 64(38), 7049-7058. https://doi.org/10.1021/acs.jafc.6b02345
Mohamed, A. A., Ali, S. I., EL-Baz, F. K., Hegazy, A. K., & Kord, M. A. (2014). Chemical composition of essential oil and in vitro antioxidant and antimicrobial activities of crude extracts of Commiphora myrrha resin. Industrial Crops and Products, 57, 10-16. https://doi.org/10.1016/j.indcrop.2014.03.017
Nadathur, S. R., Wanasundara, J. P. D., & Scanlin, L. (2017). Proteins in the diet: Challenges in feeding the global population. In S. R. Nadathur, J. P. D. Wanasundara, & L. B. T.-S. P. S. Scanlin (Eds.), Sustainable protein sources (pp. 1-19). United Kingdom: Academic Press. https://doi.org/10.1016/B978-0-12-802778-3.00001-9
Najafi, S., Koujan, S. E., Manifar, S., Kharazifard, M. J., Kidi, S., & Hajheidary, S. (2017). Preventive effect of Glycyrrhiza glabra extract on Oral Mucositis in patients under head and neck radiotherapy: A randomized clinical trial. Journal of Dentistry (Tehran, Iran), 14(5), 267-274.
Nazzaro, F., Fratianni, F., De Martino, L., Coppola, R., & De Feo, V. (2013). Effect of essential oils on pathogenic bacteria. Pharmaceuticals, 6(12), 1451-1474. https://doi.org/10.3390/ph6121451
Ni, L., Zhou, L., Zhou, M., Zhao, J., & Wang, D. W. (2020). Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19. Frontiers of Medicine, 14(2), 210-214. https://doi.org/10.1007/s11684-020-0757-x
Nicolaou, K. C., & Rigol, S. (2018). A brief history of antibiotics and select advances in their synthesis. Journal of Antibiotics, 71(2), 153-184. https://doi.org/10.1038/ja.2017.62
Nikhat, S., & Fazil, M. (2020). Overview of Covid-19; its prevention and management in the light of Unani medicine. Science of the Total Environment, 728, 138859. https://doi.org/10.1016/j.scitotenv.2020.138859
Oksana, S. (2012). Plant phenolic compounds for food, pharmaceutical and cosmetiсs production. Journal of Medicinal Plant Research, 6(13), 2526-2539. https://doi.org/10.5897/jmpr11.1695
Okuda, T., & Ito, H. (2011). Tannins of constant structure in medicinal and food plants-Hydrolyzable tannins and polyphenols related to tannins. Molecules, 16(3), 2191-2217. https://doi.org/10.3390/molecules16032191
Orak, H. H., Yagar, H., & Isbilir, S. S. (2012). Comparison of antioxidant activities of juice, peel, and seed of pomegranate (Punica granatum L.) and inter-relationships with total phenolic, tannin, anthocyanin, and flavonoid contents. Food Science and Biotechnology, 21(2), 373-387. https://doi.org/10.1007/s10068-012-0049-6
Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016). Flavonoids: An overview. Journal of Nutritional Science, 5, e47. https://doi.org/10.1017/jns.2016.41
Pandith, S. A., Dar, R. A., Lattoo, S. K., Shah, M. A., & Reshi, Z. A. (2018). Rheum australe, an endangered high-value medicinal herb of North Western Himalayas: A review of its botany, ethnomedical uses, phytochemistry and pharmacology. Phytochemistry Reviews, 17(3), 573-609. https://doi.org/10.1007/s11101-018-9551-7
Perveen, S. (2018). Introductory chapter: Terpenes and Terpenoids. In Terpenes and Terpenoids (pp. 1-12). London: IntechOpen. https://doi.org/10.5772/intechopen.79683
Pränting, M., Lööv, C., Burman, R., Göransson, U., & Andersson, D. I. (2010). The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against gram-negative bacteria. Journal of Antimicrobial Chemotherapy, 65(9), 1964-1971. https://doi.org/10.1093/jac/dkq220
Radha, M. H., & Laxmipriya, N. P. (2015). Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. Journal of Traditional and Complementary Medicine, 5(1), 21-26. https://doi.org/10.1016/j.jtcme.2014.10.006
Raja, A. F., Ali, F., Khan, I. A., Shawl, A. S., Arora, D. S., Shah, B. A., & Taneja, S. C. (2011). Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata. BMC Microbiology, 11, 54. https://doi.org/10.1186/1471-2180-11-54
Rauwald, H. W., Liebold, T., Grötzinger, K., Lehmann, J., & Kuchta, K. (2019). Labdanum and Labdanes of Cistus creticus and C. ladanifer: Anti-Borrelia activity and its phytochemical profiling✰. Phytomedicine, 60, 152977. https://doi.org/10.1016/j.phymed.2019.152977
Razi, Z. (1991). Kitab al-Mansoori, New Delhi: Central Council for Research in Unani Medicine.
Razi, Z. (2008). Kitab al-Hawi, New Delhi: Central Council for Research in Unani Medicine.
Rezaee, R., & Hosseinzadeh, H. (2013). Safranal: From an aromatic natural product to a rewarding pharmacological agent. Iranian Journal of Basic Medical Sciences, 16(1), 12-26. https://doi.org/10.22038/ijbms.2013.244
Robinson, N. G. (2012). Complementary and alternative medicine for cancer. The good, the bad, and the dangerous. In S. J. Withrow, D. M. Vail, & R. L. Page (Eds.), Withrow and MacEwen's small animal clinical oncology (5th ed., pp. 280-292). Missouri: W.B. Saunders. https://doi.org/10.1016/B978-1-4377-2362-5.00016-5
Rue, E. A., Rush, M. D., & van Breemen, R. B. (2018). Procyanidins: A comprehensive review encompassing structure elucidation via mass spectrometry. Phytochemistry Reviews, 17(1), 1-16. https://doi.org/10.1007/s11101-017-9507-3
Rushd, I. (1987). Kitab al-Kulliyat (2nd ed.) New Delhi: Central Council for Research in Unani Medicine.
Saad, B., Azaizeh, H., & Said, O. (2005). Tradition and perspectives of Arab herbal medicine: A review. Evidence-based Complementary and Alternative Medicine, 2(4), 475-479. https://doi.org/10.1093/ecam/neh133
Saghazadeh, A., & Rezaei, N. (2020). Immune-epidemiological parameters of the novel coronavirus-A perspective. Expert Review of Clinical Immunology, 16(5), 465-470. https://doi.org/10.1080/1744666X.2020.1750954
Salehi, B., Upadhyay, S., Orhan, I. E., Jugran, A. K., Jayaweera, S. L. D., Dias, D. A., … Sharifi-Rad, J. (2019). Therapeutic potential of α-and β-pinene: A miracle gift of nature. Biomolecules, 9(11), 1-34. https://doi.org/10.3390/biom9110738
Saxena, S., Lakshminarayan, N., Gudli, S., & Kumar, M. (2017). Anti bacterial efficacy of Terminalia chebula, Terminalia bellirica, Embilica officinalis and triphala on salivary Streptococcus mutans count - A linear randomized cross over trial. Journal of Clinical and Diagnostic Research, 11(2), ZC47-ZC51. https://doi.org/10.7860/JCDR/2017/23558.9355
Schmidt, T. J., Kaiser, M., & Brun, R. (2011). Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata, and evaluation of its antiprotozoal activity. Planta Medica, 77(8), 849-850. https://doi.org/10.1055/s-0030-1250612
Shahidi, F., & De Camargo, A. C. (2016). Tocopherols and tocotrienols in common and emerging dietary sources: Occurrence, applications, and health benefits. International Journal of Molecular Sciences, 17(10), 1745. https://doi.org/10.3390/ijms17101745
Shalaby, H. A., El Khateeb, R. M., El Namaky, A. H., Ashry, H. M., Kandil, O. M., & Abou El Dobal, S. K. A. (2016). Larvicidal activity of camphor and lavender oils against sheep blowfly, Lucilia sericata (Diptera: Calliphoridae). Journal of Parasitic Diseases, 40(4), 1475-1482. https://doi.org/10.1007/s12639-015-0715-8
Shen, Y. C., Juan, C. W., Lin, C. S., Chen, C. C., & Chang, C. L. (2017). Neuroprotective effect of Terminalia chebula extracts and ellagic acid in Pc12 cells. African Journal of Traditional, Complementary, and Alternative Medicines, 14(4), 22-30. https://doi.org/10.21010/ajtcam.v14i4.3
Siddiqui, M. Z. (2011). Boswellia serrata, a potential antiinflammatory agent: An overview. Indian Journal of Pharmaceutical Sciences, 73(3), 255-261. https://doi.org/10.4103/0250-474X.93507
Sina, I. (2010). Al Qanoon Fil Tibb (Urdu translation), India, Lucknow: Munshi Nawal Kishore.
Søltoft-Jensen, J., & Hansen, F. (2005). New chemical and biochemical hurdles. In F. P. Sun (Ed.), Emerging technologies for food processing (pp. 387-416). USA: Academic Press. https://doi.org/10.1016/B978-012676757-5/50017-7
Sun, Z.-G., Zhao, T.-T., Lu, N., Yang, Y.-A., & Zhu, H.-L. (2019). Research Progress of Glycyrrhizic acid on antiviral activity. Mini-Reviews in Medicinal Chemistry, 19(10), 826-832. https://doi.org/10.2174/1389557519666190119111125
Sunkara, A., & Raizner, A. (2019). Supplemental vitamins and minerals for cardiovascular disease prevention and treatment. Methodist DeBakey Cardiovascular Journal, 15(3), 179-184. https://doi.org/10.14797/mdcj-15-3-179
Swamy, M. K., Akhtar, M. S., & Sinniah, U. R. (2016). Antimicrobial properties of plant essential oils against human pathogens and their mode of action: An updated review. Evidence-based Complementary and Alternative Medicine, 2016, 1-21. https://doi.org/10.1155/2016/3012462
The National Commission for Indian System of Medicine. (2019). Retrieved from http://164.100.47.5/committee_web/BillFile/Bill/14/113/Iof2019_2019_2_15.pdf
Tresserra-Rimbau, A., Lamuela-Raventos, R. M., & Moreno, J. J. (2018). Polyphenols, food and pharma. Current knowledge and directions for future research. Biochemical Pharmacology, 156, 186-195. https://doi.org/10.1016/j.bcp.2018.07.050
Ullah, N., Azam Khan, M., Khan, T., & Ahmad, W. (2014). Protective potential of Tamarindus indica against gentamicin-induced nephrotoxicity. Pharmaceutical Biology, 52(4), 428-434. https://doi.org/10.3109/13880209.2013.840318
Ulukanli, Z., Karabörklü, S., Bozok, F., Ates, B., Erdogan, S., Cenet, M., & Karaaslan, M. G. (2014). Chemical composition, antimicrobial, insecticidal, phytotoxic and antioxidant activities of Mediterranean Pinus brutia and Pinus pinea resin essential oils. Chinese Journal of Natural Medicines, 12(12), 901-910. https://doi.org/10.1016/S1875-5364(14)60133-3
Venieri, D., Gounaki, I., Christidis, G. E., Knapp, C. W., Bouras-Vallianatos, P., & Photos-Jones, E. (2020). Bridging the gaps: Bole and terra sigillata as artefacts, as simples and as antibacterial clays. Minerals, 10(4), 1-11. https://doi.org/10.3390/min10040348
Vidyalakshmi, A., & Kruthika, K. (2012). Antibacterial activity of Parmelia perlata. Asian Pacific Journal of Tropical Biomedicine, 2 (2 SUPPL., S892-S894. https://doi.org/10.1016/S2221-1691(12)60331-1
Vishnuprasad, C. N., Pradeep, N. S., Cho, Y. W., Gangadharan, G. G., & Han, S. S. (2013). Fumigation in Ayurveda: Potential strategy for drug discovery and drug delivery. Journal of Ethnopharmacology, 149(2), 409-415. https://doi.org/10.1016/j.jep.2013.07.028
Wang, G. (2014). Human antimicrobial peptides and proteins. Pharmaceuticals, 7(5), 545-594. https://doi.org/10.3390/ph7050545
Wen, B., & Gorycki, P. (2019). Bioactivation of herbal constituents: Mechanisms and toxicological relevance. Drug Metabolism Reviews, 51(4), 453-497. https://doi.org/10.1080/03602532.2019.1655570
Whitford, D. (2013). Proteins: Structure and function, England: John Wiley & Sons.
WHO. (2010). Benchmarks for Training in Unani medicine. Retrieved from https://www.who.int/medicines/areas/traditional/BenchmarksforTraininginUnaniMedicine.pdf?ua=1
Wu, S., & Tian, L. (2017). Diverse phytochemicals and bioactivities in the ancient fruit and modern functional food pomegranate (Punica granatum). Molecules, 22(10), 1606. https://doi.org/10.3390/molecules22101606
Zaffiri, L., Gardner, J., & Toledo-Pereyra, L. H. (2012). History of antibiotics. From salvarsan to cephalosporins. Journal of Investigative Surgery, 25(2), 67-77. https://doi.org/10.3109/08941939.2012.664099
Zargar, B. A., Masoodi, M. H., Khan, B. A., & Akbar, S. (2013). Paeonia emodi Royle: Ethnomedicinal uses, phytochemistry and pharmacology. Phytochemistry Letters, 6(2), 261-266. https://doi.org/10.1016/j.phytol.2013.03.003
Zargaran, A., Zarshenas, M. M., Borhani-Haghighi, A., & Mohagheghzadeh, A. (2014). A short introduction to a 19th century Persian book on pulsology: Naiier Azam. Journal of Research on History of Medicine, 3(1), 21-24.
Zeinali, M., Zirak, M. R., Rezaee, S. A., Karimi, G., & Hosseinzadeh, H. (2019). Immunoregulatory and anti-inflammatory properties of Crocus sativus (saffron) and its main active constituents: A review. Iranian Journal of Basic Medical Sciences, 22(4), 334-344. https://doi.org/10.22038/ijbms.2019.34365.8158
Zhang, L., Ravipati, A. S., Koyyalamudi, S. R., Jeong, S. C., Reddy, N., Bartlett, J., … Vicente, F. (2013). Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs. Asian Pacific Journal of Tropical Medicine, 6(9), 673-681. https://doi.org/10.1016/S1995-7645(13)60117-0