Pilot study for the evaluation of safety profile of a potential inhibitor of SARS-CoV-2 endocytosis.


Journal

Acta bio-medica : Atenei Parmensis
ISSN: 2531-6745
Titre abrégé: Acta Biomed
Pays: Italy
ID NLM: 101295064

Informations de publication

Date de publication:
09 11 2020
Historique:
received: 03 09 2020
accepted: 17 09 2020
entrez: 10 11 2020
pubmed: 11 11 2020
medline: 20 11 2020
Statut: epublish

Résumé

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current pandemics of coronavirus disease. This virus is able to attack the cells of the airway epithelium by binding to the transmembrane angiotensin I converting enzyme 2 (ACE2). We developed an oral spray that could inhibit the SARS-CoV-2 endocytosis. The spray contains hydroxytyrosol for its anti-viral, anti-inflammatory and anti-oxidant properties, and α-cyclodextrin for its ability to deplete sphingolipids, that form the lipid rafts where ACE2 localizes. The aim of the present pilot multi-centric open non-controlled observational study was to evaluate the safety profile of the "Endovir Stop" spray. An MTT test was performed to evaluate cytotoxicity of the spray in two human cell lines. An oxygen radical absorbance capacity assay was performed to evaluate the antioxidant capacity of the spray. The spray was also tested on 87 healthy subjects on a voluntary basis. The MTT test revealed that the spray is not cytotoxic. The ORAC assay showed a good antioxidant capacity for the spray. Endovir Stop tested on healthy volunteers showed the total absence of side effects and drug interactions during the treatment. We demonstrated that Endovir Stop spray is safe. The next step would be the administration of the efficacy of the spray by testing it to a wider range of people and see whether there is a reduced infection rate of SARS-CoV-2 in the treated subjects than in the non-treated individuals.

Sections du résumé

BACKGROUND AND AIM OF THE WORK
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current pandemics of coronavirus disease. This virus is able to attack the cells of the airway epithelium by binding to the transmembrane angiotensin I converting enzyme 2 (ACE2). We developed an oral spray that could inhibit the SARS-CoV-2 endocytosis. The spray contains hydroxytyrosol for its anti-viral, anti-inflammatory and anti-oxidant properties, and α-cyclodextrin for its ability to deplete sphingolipids, that form the lipid rafts where ACE2 localizes. The aim of the present pilot multi-centric open non-controlled observational study was to evaluate the safety profile of the "Endovir Stop" spray.
METHODS
An MTT test was performed to evaluate cytotoxicity of the spray in two human cell lines. An oxygen radical absorbance capacity assay was performed to evaluate the antioxidant capacity of the spray. The spray was also tested on 87 healthy subjects on a voluntary basis.
RESULTS
The MTT test revealed that the spray is not cytotoxic. The ORAC assay showed a good antioxidant capacity for the spray. Endovir Stop tested on healthy volunteers showed the total absence of side effects and drug interactions during the treatment.
CONCLUSIONS
We demonstrated that Endovir Stop spray is safe. The next step would be the administration of the efficacy of the spray by testing it to a wider range of people and see whether there is a reduced infection rate of SARS-CoV-2 in the treated subjects than in the non-treated individuals.

Identifiants

pubmed: 33170175
doi: 10.23750/abm.v91i13-S.10583
pmc: PMC8023122
doi:

Substances chimiques

Antiviral Agents 0
Oral Sprays 0
alpha-Cyclodextrins 0
3,4-dihydroxyphenylethanol 10597-60-1
Phenylethyl Alcohol ML9LGA7468
alpha-cyclodextrin Z1LH97KTRM

Types de publication

Journal Article Multicenter Study Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2020009

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Auteurs

Stefano Paolacci (S)

MAGI'S LAB. stefano.paolacci@assomagi.org.

Maria Rachele Ceccarini (MR)

Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy. chele@hotmail.it.

Michela Codini (M)

Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy. michela.codini@unipg.it.

Elena Manara (E)

MAGI EUREGIO, Bolzano, Italy. elena.manara@assomagi.org.

Silvia Tezzele (S)

MAGI'S LAB, Rovereto (TN), Italy. silvia.tezzele@assomagi.org.

Marcella Percio (M)

MAGI'S LAB, Rovereto (TN), Italy. marcella.percio@assomagi.org.

Natale Capodicasa (N)

MAGI BALKANS, Tirana, Albania. ncapodicasa@yahoo.it.

Dorela Kroni (D)

MAGI BALKANS, Tirana, Albania. dorakroni@gmail.com.

Munis Dundar (M)

Department of Medical Genetics, Erciyes University Faculty of Medicine, Kayseri, Turkey. dundar@erciyes.edu.tr.

Mahmut Cerkez Ergoren (MC)

Department of Medical Biology, Faculty of Medicine, Near East University, Nicosia, Cyprus; DESAM Insitute, Near East University, Nicosia, Cyprus. mahmutcerkez@gmail.com.

Tamer Sanlidag (T)

DESAM Insitute, Near East University, Nicosia, Cyprus. tamer.sanlidag@neu.edu.tr.

Tommaso Beccari (T)

Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy. tommaso.beccari@unipg.it.

Marco Farronato (M)

Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan - Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. stefano.paolacci@assomagi.org.

Giampietro Farronato (G)

Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan - Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. stefano.paolacci@assomagi.org.

Gianluca Martino Tartaglia (GM)

Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan - Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. stefano.paolacci@assomagi.org.

Matteo Bertelli (M)

MAGI'S LAB, Rovereto (TN), Italy; MAGI EUREGIO, Bolzano, Italy; EBTNA-LAB, Rovereto (TN), Italy. matteo.bertelli@assomagi.org.

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Classifications MeSH