Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser.

Amino Acid Substitution / genetics Animals Black People / genetics Cell Line Glutathione / metabolism Glycolysis Humans Mitochondria / metabolism Oxidation-Reduction TOR Serine-Threonine Kinases / genetics Tumor Suppressor Protein p53 / genetics
GAPDH Pro47Ser Rheb cancer biology human mTOR metabolism mouse p53

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
10 11 2020
Historique:
received: 13 02 2020
accepted: 28 10 2020
entrez: 10 11 2020
pubmed: 11 11 2020
medline: 17 4 2021
Statut: epublish

Résumé

The Pro47Ser variant of p53 (S47) exists in African-descent populations and is associated with increased cancer risk in humans and mice. Due to impaired repression of the cystine importer

Identifiants

DOI: 10.7554/eLife.55994 PMID: 33170774 PMC: PMC7661039
pubmed: 33170774
doi: 10.7554/eLife.55994
pii: 55994
pmc: PMC7661039
doi:
pii:

Substances chimiques

Tumor Suppressor Protein p53 0
MTOR protein, human EC 2.7.1.1
mTOR protein, mouse EC 2.7.1.1
TOR Serine-Threonine Kinases EC 2.7.11.1
Glutathione GAN16C9B8O

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK098656
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK19525
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009071
Pays : United States
Organisme : NIH HHS
ID : S10 OD023586
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA114046
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA220972
Pays : United States
Organisme : NCI NIH HHS
ID : CA238611
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA241367
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA102184
Pays : United States
Organisme : NCI NIH HHS
ID : DP2-CA249951
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA238611
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009171
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA010815
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA221838
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA174761
Pays : United States
Organisme : NCI NIH HHS
ID : Cancer Center Support Grant (CCSG) P30 CA010815
Pays : United States
Organisme : NIH HHS
ID : S10 OD023658
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK019525
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG043483
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA139319
Pays : United States

Informations de copyright

© 2020, Gnanapradeepan et al.

Déclaration de conflit d'intérêts

KG, JL, SB, TB, MG, JL, WQ, CK, RA, JB, KW, QL, ZS, DG No competing interests declared, MM Senior Editor, eLife

Références

Cell. 2012 Apr 13;149(2):274-93
pubmed: 22500797
Mol Cell Biol. 2009 Jul;29(14):3991-4001
pubmed: 19451232
Nat Genet. 2001 Feb;27(2):195-200
pubmed: 11175789
Front Physiol. 2017 Oct 17;8:788
pubmed: 29089899
Genes (Basel). 2018 Nov 28;9(12):
pubmed: 30487452
J Appl Physiol (1985). 2019 Aug 1;127(2):581-590
pubmed: 30676865
NPJ Breast Cancer. 2017 Feb 27;3:5
pubmed: 28649645
Antioxid Redox Signal. 2009 May;11(5):997-1014
pubmed: 18999917
Aging (Albany NY). 2013 Jul;5(7):539-50
pubmed: 23929887
Front Genet. 2012 Sep 11;3:177
pubmed: 22973301
J Biol Chem. 2006 Sep 15;281(37):27643-52
pubmed: 16847060
Curr Biol. 2005 Apr 26;15(8):702-13
pubmed: 15854902
Genes Dev. 2016 Apr 15;30(8):918-30
pubmed: 27034505
Cell Rep. 2016 Mar 15;14(10):2413-25
pubmed: 26947067
Protein Sci. 2001 Jul;10(7):1293-304
pubmed: 11420431
Cell Cycle. 2013 Jan 1;12(1):20-5
pubmed: 23255104
Am J Physiol. 1991 Mar;260(3 Pt 1):C475-84
pubmed: 2003574
Aging Cell. 2016 Feb;15(1):155-66
pubmed: 26695882
Elife. 2018 Mar 20;7:
pubmed: 29557783
Cancer Res. 2007 Apr 1;67(7):3043-53
pubmed: 17409411
Nat Rev Mol Cell Biol. 2020 Apr;21(4):183-203
pubmed: 31937935
J Biol Chem. 1995 May 19;270(20):12109-16
pubmed: 7744859
Acta Pharmacol Sin. 2005 Dec;26(12):1421-34
pubmed: 16297339
Cell. 2009 May 1;137(3):413-31
pubmed: 19410540
Nat Commun. 2020 Jan 24;11(1):473
pubmed: 31980600
Genes Dev. 2018 Feb 1;32(3-4):230-243
pubmed: 29463573
Mol Cell Biol. 2013 Oct;33(19):3864-78
pubmed: 23897429
Front Endocrinol (Lausanne). 2018 Apr 11;9:124
pubmed: 29695998
Cell. 2008 Aug 8;134(3):451-60
pubmed: 18692468
Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9761-6
pubmed: 19470478
Proc Biol Sci. 2012 Apr 7;279(1732):1389-95
pubmed: 21993507
Cell Metab. 2013 Nov 5;18(5):698-711
pubmed: 24206664
Cell. 2017 Oct 5;171(2):273-285
pubmed: 28985560
Biochemistry (Mosc). 2010 Dec;75(12):1444-9
pubmed: 21314614
Cell Metab. 2013 Mar 5;17(3):456-62
pubmed: 23473038
N Engl J Med. 2013 Mar 14;368(11):1027-32
pubmed: 23484829
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8204-9
pubmed: 15928081
Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8390-8396
pubmed: 30962386
Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):83-8
pubmed: 21076294
Cell Metab. 2013 Nov 5;18(5):617-33
pubmed: 23954639
Science. 1991 Jul 5;253(5015):49-53
pubmed: 1905840
Sci Rep. 2017 Jul 10;7(1):5028
pubmed: 28694500
FEBS Lett. 2010 Apr 2;584(7):1287-95
pubmed: 20083114
Curr Opin Cell Biol. 2017 Apr;45:72-82
pubmed: 28411448
Cell. 2018 Jun 28;174(1):72-87.e32
pubmed: 29861175
Am J Cancer Res. 2011;1(3):362-372
pubmed: 21969237
J Physiol. 2009 Apr 1;587(Pt 7):1535-46
pubmed: 19188252

Auteurs

Keerthana Gnanapradeepan (K)

Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.
Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
ORCID: 0000-0002-8984-9742

Julia I-Ju Leu (JI)

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

Subhasree Basu (S)

Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.

Thibaut Barnoud (T)

Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.
ORCID: 0000-0001-5588-6281

Madeline Good (M)

Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.

Joyce V Lee (JV)

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

William J Quinn (WJ)

Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

Che-Pei Kung (CP)

Washington University in St. Louis, St Louis, United States.
ORCID: 0000-0002-1150-4998

Rexford Ahima (R)

Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins University School of Medicine, Baltimore, United States.

Joseph A Baur (JA)

Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
ORCID: 0000-0001-8262-6549

Kathryn E Wellen (KE)

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
ORCID: 0000-0002-2281-0042

Qin Liu (Q)

Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.

Zachary T Schug (ZT)

Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.

Donna L George (DL)

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

Maureen E Murphy (ME)

Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, United States.
ORCID: 0000-0001-7644-7296

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Substitution d'acide aminé › Increased mTOR activity and metabolic...
questionsmedicales.fr › Eucaryotes › Animaux › Increased mTOR activity and metabolic...
questionsmedicales.fr › Personnes › Noirs › Increased mTOR activity and metabolic...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Increased mTOR activity and metabolic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Increased mTOR activity and metabolic...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › Increased mTOR activity and metabolic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Increased mTOR activity and metabolic...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Increased mTOR activity and metabolic...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Increased mTOR activity and metabolic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Increased mTOR activity and metabolic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › Increased mTOR activity and metabolic...