Responsivity to light in familial hemiplegic migraine type 1 mutant mice reveals frequency-dependent enhancement of visual network excitability.
CaV2.1 calcium channels
electrophysiology
sensory systems
visual stimulation
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
revised:
13
10
2020
received:
19
05
2020
accepted:
01
11
2020
pubmed:
11
11
2020
medline:
30
6
2021
entrez:
10
11
2020
Statut:
ppublish
Résumé
Migraine patients often report (inter)ictal hypersensitivity to light, but the underlying mechanisms remain an enigma. Both hypo- and hyperresponsivity of the visual network have been reported, which may reflect either intra-individual dynamics of the network or large inter-individual variation in the measurement of human visual evoked potential data. Therefore, we studied visual system responsivity in freely behaving mice using combined epidural electroencephalography and intracortical multi-unit activity to reduce variation in recordings and gain insight into visual cortex dynamics. For better clinical translation, we investigated transgenic mice that carry the human pathogenic R192Q missense mutation in the α
Identifiants
pubmed: 33170971
doi: 10.1111/ejn.15041
pmc: PMC8048865
doi:
Substances chimiques
Calcium Channels, N-Type
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1672-1686Informations de copyright
© 2020 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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