Renal transplantation during the SARS-CoV-2 pandemic in the UK: Experience from a large-volume center.
Adult
COVID-19
/ complications
Female
Graft Rejection
/ epidemiology
Hospitals, High-Volume
/ statistics & numerical data
Humans
Kidney Transplantation
/ adverse effects
Male
Middle Aged
Retrospective Studies
SARS-CoV-2
/ isolation & purification
Transplant Recipients
/ statistics & numerical data
United Kingdom
/ epidemiology
COVID-19
SARS-CoV-2
coronavirus pandemic
kidney transplantation
organ donation
Journal
Clinical transplantation
ISSN: 1399-0012
Titre abrégé: Clin Transplant
Pays: Denmark
ID NLM: 8710240
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
02
09
2020
revised:
01
11
2020
accepted:
03
11
2020
pubmed:
11
11
2020
medline:
16
2
2021
entrez:
10
11
2020
Statut:
ppublish
Résumé
There is uncertainty about the safety of kidney transplantation during the SARS-CoV-2 pandemic due to the risk of donor transmission, nosocomial infection and immunosuppression use. We describe organ donation and transplant practice in the UK and assess whether kidney transplantation conferred a substantial risk of harm. Data from the UK transplant registry were used to describe kidney donation and transplant activity in the UK, and a detailed analysis of short-term, single-center, patient results in two periods: during the pre-pandemic era from 30th December 2019 to 8th March 2020 ("Pre-COVID era") and the 9th March 2020 to 19th May 2020 ("COVID era"). Donor and recipient numbers fell by more than half in the COVID compared to the pre-COVID era in the UK, but there were more kidney transplants performed in our center (42 vs. 29 COVID vs. pre-COVID respectively). Overall outcomes, including re-operation, delayed graft function, primary non-function, acute rejection, length of stay and graft survival were similar between COVID and pre-COVID era. 6/71 patients became infected with SARS-CoV-2 but all were discharged without critical care requirement. Transplant outcomes have remained similar within the COVID period and no serious sequelae of SARS-CoV-2 infection were observed in the peri-transplant period.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14150Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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