Enterobactin induces the chemokine, interleukin-8, from intestinal epithelia by chelating intracellular iron.
Animals
Caco-2 Cells
Cell Line, Tumor
Enterobactin
/ pharmacology
Epithelial Cells
/ metabolism
HT29 Cells
Humans
Interleukin-8
/ biosynthesis
Intestinal Mucosa
/ cytology
Iron
/ metabolism
Lipocalin-2
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Reactive Oxygen Species
/ metabolism
Receptors, Formyl Peptide
/ antagonists & inhibitors
Siderophores
/ pharmacology
IL-8
Siderophores
enterochelin
labile iron pool
lipocalin 2
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
09 11 2020
09 11 2020
Historique:
entrez:
10
11
2020
pubmed:
11
11
2020
medline:
1
10
2021
Statut:
ppublish
Résumé
Iron is an indispensable nutrient for both mammals and microbes. Bacteria synthesize siderophores to sequester host iron, whereas lipocalin 2 (Lcn2) is the host defense protein that prevent this iron thievery. Enterobactin (Ent) is a catecholate-type siderophore that has one of the strongest known affinities for iron. Intestinal epithelial cells (IECs) are adjacent to large microbial population and are in contact with microbial products, including Ent. We undertook this study to investigate whether a single stimulus of Ent could affect IEC functions. Using three human IEC cell-lines with differential basal levels of Lcn2 (
Identifiants
pubmed: 33171063
doi: 10.1080/19490976.2020.1841548
pmc: PMC7671005
doi:
Substances chimiques
CXCL8 protein, human
0
Interleukin-8
0
LCN2 protein, human
0
Lipocalin-2
0
Reactive Oxygen Species
0
Receptors, Formyl Peptide
0
Siderophores
0
Enterobactin
28384-96-5
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-18Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL143082
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA219144
Pays : United States
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