The Adrenal Medulla Modulates Mechanical Allodynia in a Rat Model of Neuropathic Pain.
Adrenal Glands
/ drug effects
Adrenal Medulla
/ metabolism
Animals
Catecholamines
/ pharmacology
Chromaffin Cells
/ drug effects
Disease Models, Animal
Epinephrine
/ metabolism
Hyperalgesia
/ metabolism
Male
Neuralgia
/ metabolism
Norepinephrine
/ metabolism
Phenylethanolamine N-Methyltransferase
/ antagonists & inhibitors
Rats
Rats, Sprague-Dawley
PNMT
adrenal medulla
chromaffin cells
neuropathic pain
stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Nov 2020
06 Nov 2020
Historique:
received:
05
10
2020
revised:
31
10
2020
accepted:
04
11
2020
entrez:
11
11
2020
pubmed:
12
11
2020
medline:
18
3
2021
Statut:
epublish
Résumé
We have investigated whether the stress response mediated by the adrenal medulla in rats subjected to chronic constriction injury of the sciatic nerve (CCI) modulates their nocifensive behavior. Treatment with SK29661 (300 mg/kg; intraperitoneal (I.P.)), a selective inhibitor of phenylethanolamine N-methyltransferase (PNMT) that converts noradrenaline (NA) into adrenaline (A), fully reverted mechanical allodynia in the injured hind paw without affecting mechanical sensitivity in the contralateral paw. The effect was fast and reversible and was associated with a decrease in the A to NA ratio (A/NA) in the adrenal gland and circulating blood, an A/NA that was elevated by CCI. 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (SKF29661) did not affect exocytosis evoked by Ca
Identifiants
pubmed: 33171955
pii: ijms21218325
doi: 10.3390/ijms21218325
pmc: PMC7664230
pii:
doi:
Substances chimiques
Catecholamines
0
Phenylethanolamine N-Methyltransferase
EC 2.1.1.28
Norepinephrine
X4W3ENH1CV
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Universidad Complutense de Madrid
ID : PR75/18-21593
Organisme : Ministerio de Ciencia e Innovación
ID : BFU2011-26253, BFU2015-70067-REDC, SAF2016-78892
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