Secondary S100B Protein Increase Following Brain Arteriovenous Malformation Rupture is Associated with Cerebral Infarction.
arteriovenous malformations
biomarker
brain
cerebrovascular malformations
intracranial hemorrhage
prognosis
stroke
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Nov 2020
06 Nov 2020
Historique:
received:
09
10
2020
revised:
30
10
2020
accepted:
03
11
2020
entrez:
11
11
2020
pubmed:
12
11
2020
medline:
29
4
2021
Statut:
epublish
Résumé
Early S100B protein serum elevation is associated with poor prognosis in patients with ruptured brain arteriovenous malformations (BAVM). The purpose of this study is to determine whether a secondary elevation of S100B is associated with early complications or poor outcome in this population. This is a retrospective study of patients admitted for BAVM rupture. A secondary increase of S100B was defined as an absolute increase by 0.1 μg/L within 30 days of admission. Fisher's and unpaired t tests followed by multivariate analysis were performed to identify markers associated with this increase. Two hundred and twenty-one ruptures met inclusion criteria. Secondary S100B protein serum elevation was found in 17.1% of ruptures and was associated with secondary infarction (
Identifiants
pubmed: 33172087
pii: molecules25215177
doi: 10.3390/molecules25215177
pmc: PMC7664396
pii:
doi:
Substances chimiques
Biomarkers
0
S100 Calcium Binding Protein beta Subunit
0
S100B protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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