Multicenter Study on Differential Human Neutrophil Antigen 2 Expression and Underlying Molecular Mechanisms.
Human neutrophil antigens
Molecular analysis
Monoallelic expression
Neutropenia
Journal
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie
ISSN: 1660-3796
Titre abrégé: Transfus Med Hemother
Pays: Switzerland
ID NLM: 101176417
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
28
08
2019
accepted:
18
12
2019
entrez:
11
11
2020
pubmed:
12
11
2020
medline:
12
11
2020
Statut:
ppublish
Résumé
The human neutrophil antigen 2 (HNA-2), which is expressed on CD177, is undetectable in 3-5% of the normal population. Exposure of these HNA-2 An international collaboration was conducted on the genetic analysis of HNA-2-phenotyped blood samples, including HNA-2-deficient individuals, mothers, and the respective children with neonatal immune neutropenia and regular blood donors. From a total of 54 HNA-2 This comprehensive study clearly demonstrates the impact of single nucleotide polymorphisms on the expression of HNA-2 on the neutrophil surface but challenges the hypothesis of regulatory epigenetic effects being implicated in the bimodal CD177 expression pattern.
Sections du résumé
BACKGROUND
BACKGROUND
The human neutrophil antigen 2 (HNA-2), which is expressed on CD177, is undetectable in 3-5% of the normal population. Exposure of these HNA-2
STUDY DESIGN
METHODS
An international collaboration was conducted on the genetic analysis of HNA-2-phenotyped blood samples, including HNA-2-deficient individuals, mothers, and the respective children with neonatal immune neutropenia and regular blood donors.
RESULTS
RESULTS
From a total of 54 HNA-2
CONCLUSION
CONCLUSIONS
This comprehensive study clearly demonstrates the impact of single nucleotide polymorphisms on the expression of HNA-2 on the neutrophil surface but challenges the hypothesis of regulatory epigenetic effects being implicated in the bimodal CD177 expression pattern.
Identifiants
pubmed: 33173457
doi: 10.1159/000505523
pii: tmh-0047-0385
pmc: PMC7590758
doi:
Types de publication
Journal Article
Langues
eng
Pagination
385-395Informations de copyright
Copyright © 2020 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors disclose no conflicts of interest.
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