Pttg1
aging
midbrain
mouse strains
regulatory variation
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
05
2020
accepted:
27
08
2020
entrez:
11
11
2020
pubmed:
12
11
2020
medline:
12
11
2020
Statut:
epublish
Résumé
Dopaminergic neurons in the midbrain are of particular interest due to their role in diseases such as Parkinson's disease and schizophrenia. Genetic variation between individuals can affect the integrity and function of dopaminergic neurons but the DNA variants and molecular cascades modulating dopaminergic neurons and other cells types of ventral midbrain remain poorly defined. Three genetically diverse inbred mouse strains - C57BL/6J, A/J, and DBA/2J - differ significantly in their genomes (∼7 million variants), motor and cognitive behavior, and susceptibility to neurotoxins. To further dissect the underlying molecular networks responsible for these variable phenotypes, we generated RNA-seq and ChIP-seq data from ventral midbrains of the 3 mouse strains. We defined 1000-1200 transcripts that are differentially expressed among them. These widespread differences may be due to altered activity or expression of upstream transcription factors. Interestingly, transcription factors were significantly underrepresented among the differentially expressed genes, and only one transcription factor,
Identifiants
pubmed: 33173537
doi: 10.3389/fgene.2020.566734
pmc: PMC7538689
doi:
Types de publication
Journal Article
Langues
eng
Pagination
566734Informations de copyright
Copyright © 2020 Gui, Thomas, Garcia, Karout, Halder, Michelucci, Kollmus, Zhou, Melmed, Schughart, Balling, Mittelbronn, Nadeau, Williams, Sauter, Buttini and Sinkkonen.
Références
Brain Res. 2009 May 13;1270:19-32
pubmed: 19272356
EMBO J. 1994 Apr 15;13(8):1799-805
pubmed: 7909512
J Biol Chem. 2010 Jul 16;285(29):22630-8
pubmed: 20452981
Nat Protoc. 2014 May;9(5):1056-82
pubmed: 24722405
Genome Biol. 2017 Oct 17;18(1):192
pubmed: 29041960
Cell Death Differ. 2008 Jan;15(1):202-12
pubmed: 17962814
Cell. 2007 May 18;129(4):823-37
pubmed: 17512414
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Science. 2000 Mar 24;287(5461):2185-95
pubmed: 10731132
BMC Genomics. 2015 Sep 02;16:655
pubmed: 26329040
Behav Brain Res. 2002 Mar 10;130(1-2):103-9
pubmed: 11864725
PLoS One. 2011 Mar 24;6(3):e17820
pubmed: 21455293
Endocr Rev. 2007 Apr;28(2):165-86
pubmed: 17325339
Nat Biotechnol. 2019 Jul;37(7):773-782
pubmed: 31061481
BMC Neurosci. 2009 May 09;10:44
pubmed: 19426526
BMC Res Notes. 2012 Jul 02;5:337
pubmed: 22748135
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Mol Vis. 2019 Jul 05;25:345-358
pubmed: 31354228
Nucleic Acids Res. 2016 Nov 16;44(20):e153
pubmed: 27484474
Nature. 2019 Sep;573(7772):61-68
pubmed: 31435019
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Science. 1999 Jul 16;285(5426):418-22
pubmed: 10411507
Prog Neurobiol. 2011 Jun;94(1):1-19
pubmed: 21439347
Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16364-9
pubmed: 17053075
Pharmacol Rep. 2012;64(5):1091-104
pubmed: 23238466
PLoS One. 2013 Apr 17;8(4):e61197
pubmed: 23613810
Bioinformatics. 2012 Dec 15;28(24):3211-7
pubmed: 23071270
Behav Brain Funct. 2011 Aug 01;7:29
pubmed: 21806802
Cell. 2018 Aug 9;174(4):1015-1030.e16
pubmed: 30096299
Pharmacol Biochem Behav. 1987 Jun;27(2):317-22
pubmed: 3628446
Genome Biol. 2014;15(12):550
pubmed: 25516281
BMC Genomics. 2010 Jan 11;11:20
pubmed: 20064228
Genome Res. 2005 Dec;15(12):1729-40
pubmed: 16339371
Cell. 2018 Jun 14;173(7):1796-1809.e17
pubmed: 29779944
J Neurochem. 2006 Apr;97 Suppl 1:50-62
pubmed: 16635250
Mol Endocrinol. 1997 Apr;11(4):433-41
pubmed: 9092795
Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3428-32
pubmed: 12626748
Brain Res. 1999 May 15;828(1-2):91-103
pubmed: 10320728
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9295-300
pubmed: 24927528
FASEB J. 2007 Jul;21(9):2226-36
pubmed: 17369508
Genes Dev. 1995 Dec 15;9(24):3136-48
pubmed: 8543157
Cell. 2007 Jul 13;130(1):77-88
pubmed: 17632057
Results Probl Cell Differ. 2000;30:21-49
pubmed: 10857184
Cell. 2019 May 2;177(4):1022-1034.e6
pubmed: 31051098
Genome Biol. 2008;9(9):R137
pubmed: 18798982
Nat Methods. 2013 Jun;10(6):577-83
pubmed: 23603899
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Science. 2012 Sep 7;337(6099):1190-5
pubmed: 22955828
J Immunol. 2014 Nov 1;193(9):4485-96
pubmed: 25267973
Biol Psychiatry. 2017 Aug 1;82(3):213-223
pubmed: 28499489
Neurobiol Aging. 1981 Fall;2(3):221-7
pubmed: 7312100
J Neurochem. 2016 Oct;139 Suppl 1:8-26
pubmed: 27206718
Mol Neuropsychiatry. 2018 Jun;4(1):35-51
pubmed: 29998117
Nature. 2002 Sep 26;419(6905):407-11
pubmed: 12353038