Epithelial-Mesenchymal Transition: Role in Cancer Progression and the Perspectives of Antitumor Treatment.
cancer
cancer stem cells
chemotherapy
epithelial–mesenchymal transition
immunotherapy
metastasis
resistance to anticancer therapy
Journal
Acta naturae
ISSN: 2075-8251
Titre abrégé: Acta Naturae
Pays: Russia (Federation)
ID NLM: 101525823
Informations de publication
Date de publication:
Historique:
entrez:
11
11
2020
pubmed:
12
11
2020
medline:
12
11
2020
Statut:
ppublish
Résumé
About 90% of all malignant tumors are of epithelial nature. The epithelial tissue is characterized by a close interconnection between cells through cell-cell interactions, as well as a tight connection with the basement membrane, which is responsible for cell polarity. These interactions strictly determine the location of epithelial cells within the body and are seemingly in conflict with the metastatic potential that many cancers possess (the main criteria for highly malignant tumors). Tumor dissemination into vital organs is one of the primary causes of death in patients with cancer. Tumor dissemination is based on the so-called epithelial-mesenchymal transition (EMT), a process when epithelial cells are transformed into mesenchymal cells possessing high mobility and migration potential. More and more studies elucidating the role of the EMT in metastasis and other aspects of tumor progression are published each year, thus forming a promising field of cancer research. In this review, we examine the most recent data on the intracellular and extracellular molecular mechanisms that activate EMT and the role they play in various aspects of tumor progression, such as metastasis, apoptotic resistance, and immune evasion, aspects that have usually been attributed exclusively to cancer stem cells (CSCs). In conclusion, we provide a detailed review of the approved and promising drugs for cancer therapy that target the components of the EMT signaling pathways.
Identifiants
pubmed: 33173593
doi: 10.32607/actanaturae.11010
pmc: PMC7604894
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4-23Informations de copyright
Copyright ® 2020 National Research University Higher School of Economics.
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